Comparative studies on the metabolism of .BETA.-dimethylaminoethanol in the mouse brain and liver follosing administration of .BETA.-dimethyl-aminoethanol and its p-chlorophenoxyacetate, meclofenoxate.

Miyazaki, Hisashi; Nambu, Keiko; Minaki, Yasuo; Hashimoto, Masahisa; Nakamura, Kiyoshi

doi:10.1248/cpb.24.763

Cited by 28 publications

(14 citation statements)

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“…The True Mechanism of Action of Centrophenoxine When 14 C-labelled DMAE or CPH was administered intravenously, much higher levels of DMAE were encountered in the brain after CPH treatment than with DMAE alone since the PCPA-esterified form of DMAE penetrates much better the bloodbrain barrier [90]. CPH is hydrolyzed on both sides of the barrier in its two component parts in vivo.…”

Section: Early Empirical Data On the Effects Of Centrophenoxinementioning

confidence: 99%

“…CPH is hydrolyzed on both sides of the barrier in its two component parts in vivo. However, the DMAE moiety becomes phosphorylated in the brain to yield phosphoryl-DMAE, which was converted to phosphatidyl-DMAE, seemingly the end-metabolite of DMAE in the brain [90]. Phosphatidyl-DMAE is incorporated in the nerve cell membranes, and remains in this form for a relatively long time on the place of choline [90], i.e.…”

Section: Early Empirical Data On the Effects Of Centrophenoxinementioning

confidence: 99%

“…it forms a special class of phospholipids in the brain cell membranes. The PCPA moiety is excreted in the urine, apparently without any metabolic change [90]. Although some fraction of DMAE administered either alone or in the form of CPH, was found in acid soluble and lipid-bound choline in the brain [90], evidence is available that trimethylation of DMAE takes place only in the liver, but not in the brain [90].…”

Section: Early Empirical Data On the Effects Of Centrophenoxinementioning

confidence: 99%

“…Obviously, neither the presence of DMAE in the brain nerve cell membranes [90], nor the in vitro OH · radical-scavenging ability of this compound [92] proves directly that it acts as an OH · radical scavenger also in vivo. However, numerous animal experimental results demonstrate indirectly that the presence of DMAE in the cell membrane is of physiological significance, which can be attributed to their local OH · radical-scavenging properties.…”

Section: Evidence For the Oh · Radical-scavenging Properties Of Centrmentioning

confidence: 99%

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Aging of Cell Membranes: Facts and Theories

Zs-Nagy

2014

Interdisciplinary Topics in Gerontology and Geriatrics

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This chapter is intended to outline the main results of a research trend realized by the author during the last 45 years, focused on the main role played by the cell membrane in the aging process. It is a very wide field; therefore, the reader cannot expect in this limited space a detailed description, but will be given a wide, interdisciplinary insight into the main facts and theories regarding cellular aging. The central idea described here is the concept called the membrane hypothesis of aging (MHA). The history, the chemical roots, physicochemical facts, biophysical processes, as well as the obligatory biochemical consequences are all touched in by indicating the most important sources of detailed knowledge for those who are more interested in the basic biology of the aging process. This chapter covers also the available anti-aging interventions on the cell membrane by means of the centrophenoxine treatment based on the MHA. It also briefly interprets the possibilities of a just developing anti-aging method by using the recombinant human growth hormone, essential basis of which is the species specificity, and the general presence of receptors of this hormone in the plasma membrane of all types of cells.

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Section: Early Empirical Data On the Effects Of Centrophenoxinementioning

confidence: 99%

Section: Early Empirical Data On the Effects Of Centrophenoxinementioning

confidence: 99%

Section: Early Empirical Data On the Effects Of Centrophenoxinementioning

confidence: 99%

Section: Evidence For the Oh · Radical-scavenging Properties Of Centrmentioning

confidence: 99%

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Aging of Cell Membranes: Facts and Theories

Zs-Nagy

2014

Interdisciplinary Topics in Gerontology and Geriatrics

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“…Differential penetration of the blood-brain barrier by several DMAE derivatives has been noted. Miyazaki et al (1976) found that radiolabeled DMAE p-chlorophenoxyacetate was found in higher concentrations in the brain than radiolabeled DMAE after intravenous treatment of mice. Higher levels of DMAE were found in the brain after dosing with centrophenoxine than with DMAE, possibly due to improved penetration of the blood-brain barrier by the esterified form of DMAE (South, undated).…”

Section: Chemical Disposition Metabolism and Toxicokineticsmentioning

confidence: 89%

Glaucopsia in Emergency Department

Uzunget¹,

Kemal²,

Bilir³

et al. 2019

Int J Crit Care Emerg Med

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Executive SummaryNomination Dimethylethanolamine (DMAE) was nominated by the NIEHS for toxicological characterization, including metabolism, reproductive and developmental toxicity, subchronic toxicity, carcinogenicity and mechanistic studies. The nomination is based on the potential for widespread human exposure to DMAE through its use in industrial and consumer products and an inadequate toxicological database. Studies to address potential hazards of consumer (e.g. dietary supplement) exposures, including use by pregnant women and children, and the potential for reproductive effects and carcinogenic effects are limited. DMAE and related ethanolamines appear to interfere with choline uptake and utilization and may also generate nitrosamines. Further studies are recommended to address these data gaps with special attention to pharmacokinetics and the influence of dietary choline. Consideration should be given to whether the bitartrate salt of DMAE (a form commonly used in dietary supplements) or other DMAE derivative is more appropriate than the free base for use in toxicology studies. Nontoxicological DataChemical Identification The principal compounds related to DMAE [108-01-0] that have common commercial uses and are discussed in this report, are DMAE aceglumate [3342-61-8], DMAE p-acetamidobenzoate (an ester) [2811-31-6], DMAE p-acetamidobenzoate (a salt); Deaner  [3635-74-3], DMAE bitartrate [5988 51-2], DMAE dihydrogen phosphate [6909-62-2], DMAE hydrochloride [2498-25-1], DMAE orotate [1446-06-6], DMAE succinate; tonibral [10549-59-4], centrophenoxine; dimethylethanolamine p-chlorophenoxyacetate hydrochloride [3685-84-5], centrophenoxine orotate [27166-15-0], and meclofenoxate; DMAE p-chlorophenoxyacetate [51-68-3].

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D

Elks¹,

Ganellin²

1990

Dictionary of Drugs

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Comparative studies on the metabolism of .BETA.-dimethylaminoethanol in the mouse brain and liver follosing administration of .BETA.-dimethyl-aminoethanol and its p-chlorophenoxyacetate, meclofenoxate.

Cited by 28 publications

References 0 publications

Aging of Cell Membranes: Facts and Theories

Aging of Cell Membranes: Facts and Theories

Glaucopsia in Emergency Department

D

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