Comparative studies on the production of the medically important radionuclide <sup>124</sup>I via p-, d-, <sup>3</sup>He- and α-particle induced reactions

Schölten, B.; Hassan, K. F.; Saleh, Z.A.; Coenen, Heinz H.; Qaim, S.M.

doi:10.1051/ndata:07238

Cited by 8 publications

(9 citation statements)

References 5 publications

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“…For production of 124 I, initially, the reaction 124 Te(d,2n) 124 I was used . Later on, cross sections of the reactions 124 Te(p,n) 124 I, 125 Te(p,2n) 124 I, and 126 Te(p,3n) 124 I as well as of 3 He‐ and α particle–induced reactions on antimony (natural and isotopically enriched isotopes) were measured over energy ranges of up to 100 MeV . A critical analysis of all the reactions was performed, and it was concluded that the 124 Te(p,n) 124 I reaction is the most suitable for the production of 124 I.…”

Section: Novel Positron Emission Tomography Radionuclidesmentioning

confidence: 99%

“…66 Later on, cross sections of the reactions 124 Te(p,n) 124 I, 125 Te(p,2n) 124 I, and 126 Te(p,3n) 124 I as well as of 3 He-and α particle-induced reactions on antimony (natural and isotopically enriched isotopes) were measured over energy ranges of up to 100 MeV. [67][68][69][70][71][72][73][74] A critical analysis of all the reactions was performed, 75,76 and it was concluded that the 124 Te(p,n) 124 I reaction 67 is the most suitable for the production of 124 I. The optimum production conditions for all investigated reactions have been recently summarized.…”

Section: I (T ½ = 418 D)mentioning

confidence: 99%

“…As an alternative, the reaction 70 Ge(α,n) 73 Se was developed. Although the theoretical yield is rather low (see Figure 2), construction of a high-current Cu 3 70 Ge target (using enriched 70 Ge) and irradiation with an 80-μA beam of 28 MeV α particles in the internal irradiation system of the compact cyclotron CV28 led to a relatively high batch yield. 103 The separation of radioactivity was performed via thermochromatography in a stream of He gas.…”

Section: Se (T ½ = 71 H)mentioning

confidence: 99%

“…5,105 Similar to that of 64 Cu, the reactor production of 67 Cu is not very fruitful. Three routes, namely, 70 Zn(p,α) 67 Cu, 70 Zn(d,αn) 67 Cu, and 68 Zn(p,2p) 67 Cu, appear to be more promising, the first 2 at a low-energy cyclotron and the latter at an intermediate-energy cyclotron or accelerator. The thick target yields calculated from their cross section data [106][107][108][109][110][111][112] are given in Figure 3.…”

Section: Cu (T ½ = 258 D)mentioning

confidence: 99%

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Development of novel radionuclides for medical applications

Qaim

Spahn

2017

Labelled Comp Radiopharmac

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Medical radionuclide production technology is well established. There is, however, a constant need for further development of radionuclides. The present efforts are mainly devoted to nonstandard positron emitters (eg, Cu, Y, I, and Se) and novel therapeutic radionuclides emitting low-range β particles (eg, Cu and Re), conversion or Auger electrons (eg, Sn and Br), and α particles (eg, Ac). A brief account of various aspects of development work (ie, nuclear data, targetry, chemical processing, and quality control) is given. For each radionuclide under consideration, the status of technology for clinical scale production is discussed. The increasing need of intermediate-energy multiple-particle accelerating cyclotrons is pointed out.

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Section: Novel Positron Emission Tomography Radionuclidesmentioning

confidence: 99%

Section: I (T ½ = 418 D)mentioning

confidence: 99%

Section: Se (T ½ = 71 H)mentioning

confidence: 99%

Section: Cu (T ½ = 258 D)mentioning

confidence: 99%

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Development of novel radionuclides for medical applications

Qaim

Spahn

2017

Labelled Comp Radiopharmac

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“…125 I can be obtained on enriched 124-126 targets in the reactions 124 Te(d, n) 125 I, 125 Te(p, n) 125 I, 125 Te(d, 2n) 125 I, and 126 Te(p, 2n) 125 I [11,12]. 125 I can be obtained on enriched 124-126 targets in the reactions 124 Te(d, n) 125 I, 125 Te(p, n) 125 I, 125 Te(d, 2n) 125 I, and 126 Te(p, 2n) 125 I [11,12].…”

Section: Evaluation Of 123-125 I Production On a Cv-28 Cyclotron Withmentioning

confidence: 99%

Production of medical 123–125I in the CV-28 cyclotron using tellurium targets

et al. 2011

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The possibility of producing large quantities of iodine isotopes of high purity in internal and external targets of a CV-28 cyclotron in reactions on protons and deuterons is studied. The advantage of using low-energy cyclotrons for such purposes is examined. It is shown that the use of a special technology for preparing targets from tellurium and a method of removing the heat released at a target irradiated by a proton beam will make it possible to produce in the CV-28 a large quantity of iodine isotopes in a relatively short time 1-2 h.Radionuclides produced in cyclotrons are widely used for diagnostics and treatment of diseases. Medical isotopes must meet stringent requirements for impurity content, since such isotopes are the basis of making preparations which are introduced into the human body.The radioactive purity of the isotopes produced in a cyclotron is determined by the chemical and radionuclide composition of the initial targets, the type and energy of the irradiating particles, and the irradiation time. The presence of radioactive impurities increases the dose load to the patient.One of the most important isotopes for diagnostics is 123 I. Because of their almost ideal nuclear-physical properties, such as the high yield of low-energy photons (83%, 159 keV), emitted after 100% electron capture, half-life 13.2 h, 123 I isotopes are a suitable product for radiopreparations with single-photon computer tomography (thyroid disease, cardiology, neurology, and oncological diseases). This isotope is also widely used in multifunctional studies. Its advantage is the low dose load on the human body and the high quality of the image showing the distribution in the body. Thus, the 123 I dose calculated for the thyroid gland and the entire body is almost 100 times lower than for other iodine isotopes. The energy of the emitted γ rays makes it possible to obtain scans of good quality. It is well known that the scan quality becomes worse for γ-ray energies falling outside the range 60-300 keV [1]. 124 I is also used for diagnostics (positron-emission tomography (PET) -diagnostics with monoclonal antibodies)

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Evaluation of excitation functions of proton and deuteron induced reactions on enriched tellurium isotopes with special relevance to the production of iodine-124

Aslam

Sudár

Hussain

et al. 2010

Applied Radiation and Isotopes

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Comparative studies on the production of the medically important radionuclide ¹²⁴I via p-, d-, ³He- and α-particle induced reactions

Cited by 8 publications

References 5 publications

Development of novel radionuclides for medical applications

Development of novel radionuclides for medical applications

Production of medical 123–125I in the CV-28 cyclotron using tellurium targets

Evaluation of excitation functions of proton and deuteron induced reactions on enriched tellurium isotopes with special relevance to the production of iodine-124

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Comparative studies on the production of the medically important radionuclide 124I via p-, d-, 3He- and α-particle induced reactions

Cited by 8 publications

References 5 publications

Development of novel radionuclides for medical applications

Development of novel radionuclides for medical applications

Production of medical 123–125I in the CV-28 cyclotron using tellurium targets

Evaluation of excitation functions of proton and deuteron induced reactions on enriched tellurium isotopes with special relevance to the production of iodine-124

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Comparative studies on the production of the medically important radionuclide ¹²⁴I via p-, d-, ³He- and α-particle induced reactions