Comparative study between effects of ginkgo biloba extract and extract loaded on gold nanoparticles on hepatotoxicity induced by potassium bromate

Osman, Amr S.; Abu-Risha, Sally; Bakr, Salwa Ibrahim; Altyar, Ahmed E.; Fayad, Eman; El-Sawi, Mamdouh R.; El-Kholy, Wafaa M.

doi:10.1007/s11356-022-22324-1

Cited by 6 publications

(4 citation statements)

References 44 publications

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“…The poor bioavailability of EGb has been associated with the presence of diterpenoid molecules, particularly in ginkgolides A, B, and C [ 199 ]. The biosynthesis of Ginkgo biloba leaves has been realized using gold nanoparticles (AuNPs), Fe 3 O 4 magnetic nanoparticles (MNPs), and silver nanoparticles (AgNPs) [ 197 , 200 , 201 ]. This technique was demonstrated by Elshazly et al, who developed AgNPs using Ginkgo biloba extract.…”

Section: Perspectives For Use Of Ginkgo Biloba In Nanotherapies Of Ne...mentioning

confidence: 99%

“…For the development of nanotherapeutics, nanoparticles are characterized using different techniques [ 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 ]. Sufficient knowledge of the safety, efficacy, and quality of nanotherapies is required to enable easy translation toward clinical applications [ 211 ].…”

Section: Perspectives For Use Of Ginkgo Biloba In Nanotherapies Of Ne...mentioning

confidence: 99%

“…Figure 10 demonstrates the potential uptake mechanism of an EGb nano-conjugate via transcytosis. biosynthesis of Ginkgo biloba leaves has been realized using gold nanoparticles (AuNPs), Fe3O4 magnetic nanoparticles (MNPs), and silver nanoparticles (AgNPs) [197,200,201]. This technique was demonstrated by Elshazly et al, who developed AgNPs using Ginkgo biloba extract.…”

Section: Green Synthesis Of Ginkgo Biloba Nanoegbmentioning

confidence: 99%

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Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy

Akanchise

Angelova

2023

Pharmaceutics

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Coronavirus infections are neuroinvasive and can provoke injury to the central nervous system (CNS) and long-term illness consequences. They may be associated with inflammatory processes due to cellular oxidative stress and an imbalanced antioxidant system. The ability of phytochemicals with antioxidant and anti-inflammatory activities, such as Ginkgo biloba, to alleviate neurological complications and brain tissue damage has attracted strong ongoing interest in the neurotherapeutic management of long COVID. Ginkgo biloba leaf extract (EGb) contains several bioactive ingredients, e.g., bilobalide, quercetin, ginkgolides A–C, kaempferol, isorhamnetin, and luteolin. They have various pharmacological and medicinal effects, including memory and cognitive improvement. Ginkgo biloba, through its anti-apoptotic, antioxidant, and anti-inflammatory activities, impacts cognitive function and other illness conditions like those in long COVID. While preclinical research on the antioxidant therapies for neuroprotection has shown promising results, clinical translation remains slow due to several challenges (e.g., low drug bioavailability, limited half-life, instability, restricted delivery to target tissues, and poor antioxidant capacity). This review emphasizes the advantages of nanotherapies using nanoparticle drug delivery approaches to overcome these challenges. Various experimental techniques shed light on the molecular mechanisms underlying the oxidative stress response in the nervous system and help comprehend the pathophysiology of the neurological sequelae of SARS-CoV-2 infection. To develop novel therapeutic agents and drug delivery systems, several methods for mimicking oxidative stress conditions have been used (e.g., lipid peroxidation products, mitochondrial respiratory chain inhibitors, and models of ischemic brain damage). We hypothesize the beneficial effects of EGb in the neurotherapeutic management of long-term COVID-19 symptoms, evaluated using either in vitro cellular or in vivo animal models of oxidative stress.

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Section: Perspectives For Use Of Ginkgo Biloba In Nanotherapies Of Ne...mentioning

confidence: 99%

Section: Perspectives For Use Of Ginkgo Biloba In Nanotherapies Of Ne...mentioning

confidence: 99%

Section: Green Synthesis Of Ginkgo Biloba Nanoegbmentioning

confidence: 99%

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Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy

Akanchise

Angelova

2023

Pharmaceutics

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“…[69][70][71] Isorhamnetin 3-O-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (compound 3) and quercetin 3-O-β-D-glucopyranosyl-(1→2)-α-Lrhamnopyranoside (compound 4) were formerly isolated from Ginkgo biloba leaf extract (family Ginkgoaceae) which is well known of its hepatoprotective, nephroprotective, anti-inflammatory and antioxidant effects. [72][73][74] Compound 4 revealed free radicle inhibition activity in HL-60 cell line, besides it displayed powerful free radical scavenging activity in the 2,2-diphenylpicrylhydrazyl (DPPH) assay showing IC 50 value of 16.1 µg/mL relative to 3.6 µg/mL of gallic acid. While compound 3 showed a lower effect.…”

Section: Effect Of S Sinuatus Methanol Leaf Extract Treatment On Infl...mentioning

confidence: 99%

In vivo hepatoprotective and nephroprotective effects ofStenocarpus sinuatusleaf extract against ifosfamide‐induced toxicity in rats

Younis,

Ayoub,

George

et al. 2023

Archiv der Pharmazie

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Ifosfamide (IFOS) is a broad‐spectrum chemotherapeutic agent that has been extensively used for breast cancer and other solid tumors. Unfortunately, its use is associated with toxicities of several organs. Stenocarpus sinuatus is an Australian tree belonging to the Proteaceae family. In the current study, the phytochemical constituents of S. sinuatus methanol leaf extract (SSLE) were assessed. In addition, the protective effect of SSLE against IFOS‐induced nephrotoxicity and hepatotoxicity was evaluated. Rats were randomly divided into six groups: control, IFOS (50 mg/kg), IFOS + SSLE (100 mg/kg), IFOS + SSLE (200 mg/kg), IFOS + SSLE (400 mg/kg), and SSLE (400 mg/kg). Hepatoprotective and nephroprotective potency of SSLE was assessed using different biochemical parameters. The phytochemical investigation resulted in the isolation of four flavonoid glycosides (kaempferol 3‐O‐β‐ d‐glucopyranosyl‐(1→2)‐α‐ l‐rhamnopyranoside, kaempferol 3‐O‐α‐rhamnopyranoside, isorhamnetin 3‐O‐β‐ d‐glucopyranosyl‐(1→2)‐α‐ l‐rhamnopyranoside, and quercetin 3‐O‐β‐ d‐glucopyranosyl‐(1→2)‐α‐ l‐rhamnopyranoside) and a coumarin (scopoletin). This is the first report on the isolated compounds from the genus Stenocarpus. SSLE showed enhancement of kidney and liver functions and reduction of oxidative stress and inflammation. The histopathology of the investigated organs confirmed the protective effect of SSLE. In conclusion, SSLE is considered as a promising candidate that can be used in defense against the toxic effects of IFOS after further clinical trials.

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Biosynthesized Gold Nanocatalyst Using Ginkgo Biloba Fruit Extract for Efficient Catalytic Degradation of Azo Dyes

Liu,

Mahmud

2024

ChemistrySelect

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Gold nanoparticles (AuNPs) are increasingly utilized for their opto‐electrical properties in various high‐tech applications, including electronic conductors, sensory probes, and drug delivery systems. However, their widespread application is limited by their tendency to agglomerate. In this study, AuNPs were synthesized using a cleaner approach and stabilized with Ginkgo biloba fruit extract (GBFE), avoiding toxic agents. The synthesis parameters were optimized using a one‐variable‐at‐a‐time technique, resulting in primarily spherical/oval particles with high crystallinity (d‐spacing=0.204–0.231 nm), nano‐scale size (10.3±2.9 nm), and remarkable stability (zeta potential of −20.06 mV). The synthesis mechanism involved a redox reaction between phytochemicals and metal cations, leading to the generation and stabilization of AuNPs. The AuNPs exhibited catalytic activity in reducing two azo compounds, i. e., reactive yellow 179 (RY179) and reactive orange 5 (RO5) as the models, achieving a degradation rate of over 98 % within 15 minutes. The kinetic rate constants (k) for RY179 and RO5 were calculated as 0.2771 min−1 and 0.2297 min−1, respectively. The AuNPs alone could not degrade azo dyes since NaBH4 was required to provide a source of electrons for transferring to the dye molecules. This eco‐friendly synthesis method demonstrates the potential for synthesizing catalytically active AuNPs for various industrial applications, including wastewater treatment.

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Comparative study between effects of ginkgo biloba extract and extract loaded on gold nanoparticles on hepatotoxicity induced by potassium bromate

Cited by 6 publications

References 44 publications

Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy

Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy

In vivo hepatoprotective and nephroprotective effects ofStenocarpus sinuatusleaf extract against ifosfamide‐induced toxicity in rats

Biosynthesized Gold Nanocatalyst Using Ginkgo Biloba Fruit Extract for Efficient Catalytic Degradation of Azo Dyes

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