Comparative study between intraperitoneal bupivacaine and bupivacaine-nalbuphine for postoperative pain relief after laparoscopic cholecystectomy

Ali, Wegdan A.; Ali, Nagy; Sewefy, Alaa M.; Ahmed, Aya H

doi:10.4103/roaic.roaic_101_18

Cited by 3 publications

(3 citation statements)

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“…Lower consumption of opioid in patients with interpleural analgesia. This finding was in accordance with another comparative study where interpleural bupivacaine and nalbuphine achieved lower pain scores, lower analgesic consumption over 24 hours, or longer duration of analgesia when compared with local anesthetics alone 3 . On the other side, intraperitoneal instillation of bupivacaine in combination with dexmedetomidine was superior to bupivacaine alone and bupivacaine tramadol 17 .…”

Section: Discussionsupporting

confidence: 92%

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Efficacy and opioid-sparing effect of interpleural bupivacaine in patients undergoing laparoscopic cholecystectomy: Prospective observational study (Running title: Efficacy of inter-pleural bupivacaine in laparoscopy)

Prasath¹,

Kumar²,

Angamuthammal³

et al. 2021

Serb J Anest Inten Therapy

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Introduction: Laparoscopic cholecystectomy is considered minimally invasive, but pain following laparoscopy is moderate to severe, leading to increased morbidity and length of hospital stay. Various medications, including opioids, NSAIDs, and techniques like intraperitoneal local anesthetic infiltration, are used. In this study, we investigated interpleural block with bupivacaine for pain relief following laparoscopic cholecystectomy. Methods: A total of 60 patients were included in the study. 30 patients received 20 ml of 0.5% interpleural bupivacaine (group 1), and 30 patients recieved 20 ml of 0.9% normal saline (group 2). We recorded visual analog score (VAS), vital signs, and postoperative opioid requirements. Tramadol (2 mg/kg) was rescue medication if VAS ≥ 5. Results: Significant difference between study groups was recorded among VAS scores measured at 30 minutes, 1, 2, 6, 10, and 12 hours (p value < 0.05). The difference in VAS scores at 15 minutes and 14 hours between study groups was insignificant (p value > 0.05). The number of patients who received tramadol was 9 (30%) patients in group 1 and 29 (96.7%) patients in group 2. The difference in proportion for tramadol intake at 6 hours was significant among study groups (p-value < 0.05). Conclusion: Interpleural bupivacaine 20 ml of 0.5% used as analgesia reduces post-operative opioid requirement following laparoscopic cholecystectomy. Hence interpleural block can be safely used as a regional technique for pain relief following laparoscopic cholecystectomy.

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Section: Discussionsupporting

confidence: 92%

“…Laparoscopic cholecystectomy (LC) is the standard treatment for symptomatic gallstone disease 2 . It is considered a minimally invasive technique characterized by reduced surgical trauma, post-operative pain, respiratory complications, cosmetically smaller incision, and length of hospital stay compared to open surgery 3 .…”

Section: Introductionmentioning

confidence: 99%

Efficacy and opioid-sparing effect of interpleural bupivacaine in patients undergoing laparoscopic cholecystectomy: Prospective observational study (Running title: Efficacy of inter-pleural bupivacaine in laparoscopy)

Prasath¹,

Kumar²,

Angamuthammal³

et al. 2021

Serb J Anest Inten Therapy

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“…In a study conducted by Ali et al ., a higher incidence of nausea and vomiting was found in the control group as compared to bupivacaine alone and bupivacaine with the nalbuphine group, which was statistically significant. [ 20 ] In yet another study, a higher incidence of emetic symptoms in the control group as compared to ropivacaine alone and ropivacaine with the nalbuphine group was observed, which was statistically insignificant. [ 18 ] This finding of nausea and vomiting seen in our study can be attributed to the pharmacodynamic effect of nalbuphine on the chemoreceptor trigger zone, and due to its direct effect on the gastro-intestinal tract.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Efficacy of Intraperitoneal Instillation of Butorphanol Versus Nalbuphine as Adjuvants to Ropivacaine for Postoperative Pain Relief in Patients Undergoing Laparoscopic Cholecystectomy Under General Anesthesia

Mahajan

Singh

Kaur

et al. 2022

Anesthesia Essays &Amp; Researches

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Background and Aims: Postoperative pain after laparoscopic cholecystectomy is very common complication hindering the early return of routine activity. Since agonist opioids are not easily available, the most common drug used for intraoperative analgesia is intravenous butorphanol in our institute. The purpose of our study is to compare the analgesic effect of intraperitoneal butorphanol and nalbuphine as additives with ropivacaine in laparoscopic cholecystectomy for postoperative pain. Setting and Design: Randomized, double-blind prospective study undertaken after approval from the Institutional Ethics Committee. Materials and Methods: In this study, 90 patients undergoing laparoscopic cholecystectomy were randomly divided into three groups: group A received intraperitoneal ropivacaine 0.2% of 20 mL with butorphanol 2 mg; Group B received intraperitoneal ropivacaine 0.2% 20 mL with nalbuphine 10 mg; and Group C received intraperitoneal ropivacaine 0.2% 20 mL with 0.9% normal saline. The primary outcome was to compare the analgesic efficacy of butorphanol with nalbuphine and the duration of postoperative pain relief. The secondary outcomes included the comparison of hemodynamic parameters, frequency of rescue analgesia, and complications among the three groups. Statistical Analysis: The data analysis was carried out with ANOVA and Chi-square test using the SPSS software version 26.0. Results: The mean of the Numeric Rating Scale pain score was insignificant in Group A versus B at all-time intervals indicating similar efficacy of butorphanol and nalbuphine in terms of pain relief postoperatively. However, the time to first rescue analgesia was significantly higher in Group A (5.70 ± 3.57 h), followed by Group B (3.95 ± 2.06 h) and Group C (2.50 ± 1.24 h). Conclusion: Butorphanol is better analgesic than nalbuphine as postoperative pain-free period was relatively more with lesser complications.

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A comparative study of the analgesic efficacy of intraperitoneal instillation of diluted bupivacaine versus non-diluted bupivacaine after laparoscopic cholecystectomy, a prospective single-blinded controlled randomized study

Abdelraheem Mohamed,

Elsayed,

Badawy

2023

Egyptian Journal of Anaesthesia

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Comparative study between intraperitoneal bupivacaine and bupivacaine-nalbuphine for postoperative pain relief after laparoscopic cholecystectomy

Cited by 3 publications

References 1 publication

Efficacy and opioid-sparing effect of interpleural bupivacaine in patients undergoing laparoscopic cholecystectomy: Prospective observational study (Running title: Efficacy of inter-pleural bupivacaine in laparoscopy)

Efficacy and opioid-sparing effect of interpleural bupivacaine in patients undergoing laparoscopic cholecystectomy: Prospective observational study (Running title: Efficacy of inter-pleural bupivacaine in laparoscopy)

Comparison of the Efficacy of Intraperitoneal Instillation of Butorphanol Versus Nalbuphine as Adjuvants to Ropivacaine for Postoperative Pain Relief in Patients Undergoing Laparoscopic Cholecystectomy Under General Anesthesia

A comparative study of the analgesic efficacy of intraperitoneal instillation of diluted bupivacaine versus non-diluted bupivacaine after laparoscopic cholecystectomy, a prospective single-blinded controlled randomized study

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