Comparative Study of a Portable Monitor for Prothrombin Time Determination, Coaguchek&lt;sup&gt;®&lt;/sup&gt;, with Three Systems for Control of Oral Anticoagulant Treatment

Vacas, Marta; Lafuente, P.J.; Cuesta, S. Murillo; Iriarte, J.A.

doi:10.1159/000022449

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…The laboratory that determined PT using the Neoplastine/STA system in citrated venous plasma obtained a similar correlation as that in other studies [13].…”

Section: Discussionsupporting

confidence: 77%

Comparative Study of a Portable Prothrombin Time Monitor Employing Three Different Systems in Oral Anticoagulant Units

Vacas

Fernández²,

Martínez-Brotóns³

et al. 2001

Pathophysiol Haemos Thromb

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The aim of this study was to evaluate the accuracy of the portable coagulometer CoaguChek^® (Roche Diagnostics) as a prothrombin time (PT) monitor, and to correlate capillary blood results with those of three different routine methods used for monitoring oral anticoagulant therapy (OAT): capillary, plasma and whole blood samples. Three hospitals participated in the study with a total of 235 patients on OAT. The international normalized ratio (INR) results obtained with CoaguChek were compared with those obtained using each of the routine methods. The study presents a good correlation between the PT monitor and the three methods studied: r = 0.9745 (hospital A), r = 0.9283 (hospital B), r = 0.9136 (hospital C). A simplified concordance test of the methods results in a nine-field comparison table showing concordances of 87.2, 85.7 and 68.4%, respectively. The absolute difference (mean ± SD) between laboratory A and CoaguChek INRs was 0.0571 ± 0.2042, with values of 0.04286 ± 0.3906 for laboratory B and 0.6986 ± 0.6170 for laboratory C. These results confirm that CoaguChek could be used as a new method for oral anticoagulant monitoring, and is in best agreement with the capillary blood PT system.

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“…The laboratory that determined PT using the Neoplastine/STA system in citrated venous plasma obtained a similar correlation as that in other studies [13].…”

Section: Discussionsupporting

confidence: 77%

Comparative Study of a Portable Prothrombin Time Monitor Employing Three Different Systems in Oral Anticoagulant Units

Vacas

Fernández²,

Martínez-Brotóns³

et al. 2001

Pathophysiol Haemos Thromb

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“…Technological advances have lead to the development of user-friendly POC analysers that provide good accuracy using smaller blood samples (12). Numerous studies have shown CoaguChek to be a reliable instrument for INR determination in adult patients requiring anticoagulant therapy (13)(14)(15)(16)(17)(18)(19). In comparison, there has only been one study evaluating the clinical effectiveness of CoaguChek compared to venous INR monitoring in children (9).…”

Section: Discussionmentioning

confidence: 99%

Point of care monitoring of oral anticoagulant therapy in children: comparison of CoaguChek Plus and Thrombotest methods with venous international normalised ratio

Ignjatović¹,

Barnes²,

Newall³

et al. 2004

Thromb Haemost

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This paper reports the outcome of a research protocol aimed at optimising warfarin monitoring in a tertiary pediatric centre. The Thrombotest INR was the standard monitoring test employed to manage oral anticoagulant therapy in children at the Royal Children's Hospital (RCH), Melbourne. This study compares the results of this standard method to the novel CoaguChek INR monitor and the "gold standard" technique of venous INR sampling. The objectives were to determine 1) if point-of-care techniques of measuring the INR (Thrombotest and CoaguChek) are accurate and reliable compared to INR results obtained from venous sampling, processed in an accredited laboratory, and 2) if INR results generated by POC devices can be safely used to manage oral anticoagulant therapy in children. 18 children (10 females and 8 males) participated in the study. Ages ranged from 9 months to 21 years (Mean 11.9 years; SD 5.03 years). The agreement between CoaguChek and venous INR measurements (r = 0.885) was shown to be higher compared to Thrombotest and venous INR (r = 0.700). Compared to the venous INR, values obtained with Coaguchek and Thrombotest crossed into or out of the therapeutic range in 25% and 36% of cases respectively. In 88% of the CoaguChek cases and 57% Thrombotest cases, the difference from the venous result was less than 0.5. The CoaguChek method of INR monitoring is a more accurate and reliable method compared to Thrombotest, in the pediatric population tested, and can be safely used to manage oral anticoagulant therapy in children.

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“…The European Concerted Action on Anticoagulation (ECAA) among others have recommended an external calibration of the ISI value [46,50,74,76,[110][111][112]. It is possible to calibrate the CoaguChek R coagulometer using fresh, citrated plasma [75] and even lyophlized plasma [112].…”

Section: Calibrationmentioning

confidence: 99%

Self-Management of Oral Anticoagulant Therapy: A Review

Christensen

2004

J Thromb Thrombolysis

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Patient self-management of oral anticoagulant therapy has over the last years gained increasing attention and widespread use. The method implies self-testing using a coagulometer (point-of-care device) and self-dosaging of coumarin. The method entails advantages for selected patients, who do not need to go to the hospital or family doctor for blood specimen and drug dosage adjustment. In contrast to patients on conventional management, patients performing self-managing have a reduced binding to the health care system, and it allows these patients unhindered to travel and manage their job or school. Therefore, the patients have a high degree of compliance because they are highly motivated. This has been the main justification for patient self-management. Furthermore, the conducted trials have also indicated a better quality of treatment compared to conventional management. In this paper the different aspects of this new treatment modality are critically reviewed, with special focus on the published clinical studies and the evaluation of the used coagulometers.

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Comparative Study of a Portable Monitor for Prothrombin Time Determination, Coaguchek<sup>®</sup>, with Three Systems for Control of Oral Anticoagulant Treatment

Cited by 9 publications

References 16 publications

Comparative Study of a Portable Prothrombin Time Monitor Employing Three Different Systems in Oral Anticoagulant Units

Comparative Study of a Portable Prothrombin Time Monitor Employing Three Different Systems in Oral Anticoagulant Units

Point of care monitoring of oral anticoagulant therapy in children: comparison of CoaguChek Plus and Thrombotest methods with venous international normalised ratio

Self-Management of Oral Anticoagulant Therapy: A Review

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