Comparative study of ampicillin and amoxycillin after intravenous, intramuscular and oral administration in homing pigeons (Columba livia)

Dorrestein, Gerry M.; Gogh, H. Van; Rinzema, J.D.; Buitelaar, Marije

doi:10.1016/s0034-5288(18)30716-1

Cited by 26 publications

(27 citation statements)

References 9 publications

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“…After intramuscular administration the data of both drug substances fitted an open one compartment model with first order absorption in turkeys and chickens. A similar result with amoxicillin was reported by Dorrestein et al (1987) in the pigeon.…”

Section: Discussionsupporting

confidence: 90%

“…For birds only a few pharmacokinetic data on /Mactams have been published. Dorrestein et al (1987) reported in the pigeon a shorter mean half-life of amoxicillin after intravenous (0.76 ± 0.16 h) and intramuscular (0.55 ±0.11 h) administration than we have found in the chicken and turkey. Mean residence time (MRT) is the statistical moment analogy to half-life.…”

Section: Discussioncontrasting

confidence: 69%

“…The difference in rate of excretion of clavulanic acid reflected in the clearance values may be due to differences in the elimination half-life (ij^) of the drug, but this was not the case with amoxicillin. The body clearances of amoxicillin in both species were found to be slower than that reported by Dorrestein et al (1987) in pigeons, and somewhat faster than that found in some mammals (Craigmill et al, 1992;Montesissa et al, 1988).…”

Section: Discussioncontrasting

confidence: 51%

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Pharmacokinetics of amoxicillin‐clavulanic acid combination after intravenous and intramuscular administration to turkeys and chickens

Escudero

1995

Avian Pathology

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SUMMARYThe pharmacokinetic behaviour of amoxicillin/clavulanic acid (4:1) combination was studied after intravenous and intramuscular administration of single doses (25 mg/kg body weight) to 15 turkeys and 15 chickens. The objective was to determine whether there are differences between turkeys and chickens in the disposition kinetics of amoxicillin and clavulanic acid. The plasma concentrations-time data were analysed by compartmental pharmacokinetic and non-compartmental methods. The disposition curves for both drugs after intravenous administration were best described by a two-compartment open model in turkeys and chickens. The apparent volumes of distribution of amoxicillin and clavulanic acid were similar in the two species. The body clearances of amoxicillin and clavulanic acid in turkeys were significantly slower than in chickens. The elimination half-life of amoxicillin was similar in turkeys (1.12 ±0.09 h) and chickens (1.03 ±0.11 h) after intravenous administration, but that of clavulanic acid differed significantly (P<0.05) between turkeys (1.12 ±0.03 h) and chickens (0.98 ± 0.05 h). After intramuscular administration both drugs had a significantly longer half-life (P<0.05) in turkeys and chickens than that after the intravenous treatment. The bioavailability after the intramuscular injection was high and similar with both drugs, but higher values were obtained for chickens than turkeys.

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 69%

Section: Discussioncontrasting

confidence: 51%

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Pharmacokinetics of amoxicillin‐clavulanic acid combination after intravenous and intramuscular administration to turkeys and chickens

Escudero

1995

Avian Pathology

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“…Using Akaike's information criterion (AIC) (33), we fitted the ampicillin and sulbactam plasma concentration vs time data after intravenous administration of the combination preparation to a two-compartment open model. This conclusion is in agreement with that found in previous studies of ampicillin carried out in various animals species (8,11,21,22,30) and in humans (5,14). However, the data for sulbactam are reported to best fit a two-compartment model in sheep and a one-compartment model in calves when the same combination of drugs was administered (20).…”

Section: Discussionsupporting

confidence: 94%

“…No significant differences between ampicillin and sulbactam after intravenous administration were found in the apparent volume of distribution, calculated by the area method (Varea). The ampicillin Varea value is similar to that reported in sheep (22), greater than the value reported in dogs of 0.27 1/kg (2), but smaller than the values reported for other animal species (1,8,11). Perhaps the most important kinetic parameter is the half-life (t112p).…”

Section: Discussionsupporting

confidence: 64%

Some pharmacokinetic parameters of ampicillin/sulbactam combination after intravenous and intramuscular administration to goats

Espuny

et al. 1996

Veterinary Quarterly

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Taking into account the results of the recent study of swine farmers' health (12), it is advisable not to undertake professional activities when animals are being fed because high exposure to endotoxins can be expected. Exposure levels can be decreased by improving the construction of animal buildings and appliances, and hygienic measures. Advising the farmer in these matters, the practitioner will also contribute to a lower exposure for himself during occupational activities in animal buildings. ACKNOWLEDGEMENTSWe thank Glaxo B.V. (Zeist, the Netherlands) for putting Wright Peak Flow mini-meters at our disposal. A special word of thanks and appreciation is for the participating veterinarians who made this study possible. intramuscular administration were 0.32 ± 0.04 h and 0.71 ± 0.14 Ii, respectively. For sulbactam the half-lives were 0.79 ± 0.18 h and 1.13 ± 0.21 h after administration by the same routes. The bioavailability after intramuscular injection was high and similar for both drugs (98,29% REFERENCESfor ampicillin and 101.84% for sulbactam). The mean peak plasma levels of ampicillin (0.43 ± 0.27 h) and sulbactam (0.34 ± 0.14 h) were reached at a similar time, and peak concentrations were also similar and non-proportional to the dose of the products administered (11.02 ± 3.11 mg/1 of ampicillin and 9.5 ± 0.98 tng/1 of sulbactam).

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Antimicrobial Drug Use in Companion Birds

Flammer¹

2013

Antimicrobial Therapy in Veterinary Medicine

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Comparative study of ampicillin and amoxycillin after intravenous, intramuscular and oral administration in homing pigeons (Columba livia)

Cited by 26 publications

References 9 publications

Pharmacokinetics of amoxicillin‐clavulanic acid combination after intravenous and intramuscular administration to turkeys and chickens

Pharmacokinetics of amoxicillin‐clavulanic acid combination after intravenous and intramuscular administration to turkeys and chickens

Some pharmacokinetic parameters of ampicillin/sulbactam combination after intravenous and intramuscular administration to goats

Antimicrobial Drug Use in Companion Birds

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