Comparative Study of Antibacterial Activity of Plant Ex-Tracts From Several Regions of Asia

Al-Judaibi, Awatif; Al-Zahrani, Ashwag; Altammar, Khadijah A.; Ismail, Salmah; Darweesh, Nadia T.

doi:10.3844/ajptsp.2014.139.147

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…Additionally, 96% ethanol contains a small amount of water, allowing it to absorb more active substances. Ethanol is also a universal solvent that can dissolve both polar and nonpolar compounds, ensuring that the required active compounds are fully extracted (Al-Judaibi, Al-Zahrani, Altammar, Ismail, & Darweesh, 2014).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Effects of Annona squamosa Leaf Extract on Staphylococcus aureus Growth: An In Vitro Study

Irawan

Rohmah

Rahmawati

et al. 2023

JBC

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Introduction: Mastitis is inflammation of the breast tissue due to infection with the Staphylococcus aureus bacteria causing local infections. It takes the natural ingredient Annona squamosal extract as an antimicrobial. Purpose: to determine the effectiveness of Annona squamosa leaf extract on the inhibition and killing power of Staphylococcus. Method: Experimental laboratory research with antibacterial activity test. Tube dilution method by incorporating bacteria and extracts with concentrations of 20%, 22.5%, 25%, 27.5%, 30%, and 32.5% and then measuring the MIC. The diffusion method is carried out by planting bacteria in a Nutrient Agar Plate and then giving the extract with 6 concentrations to calculate the MBC. Results: The results of the One-Way ANOVA test obtained a significance value of (p<0.001), indicating that changes in the concentration of Annona squamosa made a significant difference to Staphylococcus. The correlation test showed a significant p-value of (p<0.001), which means that there was a significant relationship between the administration of extract and the number of Staphylococcus. Conclusion: Annona squamosa leaf extract is able to significantly inhibit the growth of Staphylococcus bacteria and the higher the concentration of Annona squamosa leaf extract, the fewer the number of bacterial colonies that grow.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Effects of Annona squamosa Leaf Extract on Staphylococcus aureus Growth: An In Vitro Study

Irawan

Rohmah

Rahmawati

et al. 2023

JBC

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“…Methanolic pits extract of Phoenix dactylifera also has activity against Escherichia coli and K pneumoniae. 8,35…”

Section: Discussionmentioning

confidence: 99%

Effects of Phoenix dactylifera Ajwa on Infection, Hospitalization, and Survival Among Pediatric Cancer Patients in a University Hospital: A Nonrandomized Controlled Trial

et al. 2019

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This nonrandomized controlled trial determined the effects of Phoenix dactylifera palm date (Ajwa) intake on the number of infections and hospitalizations associated with fever, neutropenia, and mortality of pediatric cancer patients admitted between 2008 and 2017 to King Abdulaziz University Hospital (Jeddah, Saudi Arabia). Patients were eligible to be enrolled if they fulfilled the inclusion criteria, were not allergic to Ajwa, and were not enrolled in another study. Of 200 screened patients, 56 were included and 144 were excluded. Of the 56, 26 agreed to take Ajwa, and 30 served as controls. Both groups were assessed based on infection rates, frequency of hospital admissions for fever and neutropenia, and mortality rate. Background information regarding demographics, clinicopathological data, and treatment options was documented. Supplementation of Ajwa significantly reduced hospital admissions (for fever-associated neutropenia) and infections (P = .009 and P < .001, respectively). Off-treatment did not significantly differ between the Ajwa and control groups. The Ajwa group had a better survival rate in comparison to the non-Ajwa group (stratified log-rank P = .005), where the main cause of death of patients in the non-Ajwa group was disease progression associated with infections (77%). In summary, Ajwa intake during the standard treatment of pediatric cancer patients improved their treatment outcome.

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“…Currently, antibiotics are used to treat this disease, but researchers have investigated herbal plants with antibacterial activities as the alternative [ 8 – 10 ]. Moreover, concerns have been raised about the overuse of antibiotics associated to the emergence of multi-drugs resistance bacteria.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and anti-inflammatory activities of Nothopanax scutellarium, Moringa oleifera and Piper betle extracts on staphylococcal mastitis animal model

Sriyanti,

Siregar,

Mudatsir

et al. 2023

Narra J

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Inappropriate and prolonged administration of antibiotics in mastitis could cause antibiotic resistance and herbal treatment might could be one alternative treatment. Nothopanax scutellarium, Moringa oleifera, and Piper betle are medicinal plants that contain various active compounds, including antibacterial and anti-inflammatory agents, but their potentials in treating mastitis are not well understood. The aim of this study was to assess the effectiveness of those plants against mastitis in rabbit model induced by Staphylococcus aureus. A total of 25 lactating rabbits (Oryctolagus cuniculus) weighing 3.0±0.4 kg were grouped into five groups: healthy control; mastitis control, and three treatment groups (Nothopanax scutellarium, Moringa oleifera, and Piper betle). Except the healthy control group, all animals were inoculated with 0.15 mL of Staphylococcus aureus containing 1.5x107colony forming unit (CFU)/mL on eight days after giving birth. The extract was administered orally after four hours Staphylococcus aureus inoculation at a dose of 50 mg/kg body weight, twice a day for five consecutive days. The number of bacteria in the milk and the level of serum interleukin 6 (IL-6) were measured and histopathological examination of mammary gland tissues were analyzed. The log number of total plate count of Staphylococcus aureus indicated that all extract groups had significant lower of bacterial logs compared to mastitis control (all comparisons had p<0.05) with the lowest was found in Piper betle group, followed by Nothopanax scutellarium and Moringa oleifera. The enzyme-linked immunosorbent assay (ELISA) results showed that all ethanolic extract groups had significantly lower levels of IL-6 compared to the mastitis control (all comparisons had p<0.05). The histopathologyassessment suggested that extract groups had lower infiltration of inflammatory cells such as lymphocytes and macrophages in alveoli compared to the mastitis control group. In conclusion, all three extracts contained antibacterial and anti-inflammatory activities and Piper betle had the most effective in reducing bacterial growth and IL-6 level compared to others.

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Comparative Study of Antibacterial Activity of Plant Ex-Tracts From Several Regions of Asia

Cited by 7 publications

References 34 publications

Antimicrobial Effects of Annona squamosa Leaf Extract on Staphylococcus aureus Growth: An In Vitro Study

Antimicrobial Effects of Annona squamosa Leaf Extract on Staphylococcus aureus Growth: An In Vitro Study

Effects of Phoenix dactylifera Ajwa on Infection, Hospitalization, and Survival Among Pediatric Cancer Patients in a University Hospital: A Nonrandomized Controlled Trial

Antibacterial and anti-inflammatory activities of Nothopanax scutellarium, Moringa oleifera and Piper betle extracts on staphylococcal mastitis animal model

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