Comparative study of antidiabetic, bactericidal, and antitumor activities of MEL@AgNPs, MEL@ZnONPs, and Ag–ZnO/MEL/GA nanocomposites prepared by using MEL and gum arabic

Bakur, Abdelmoneim; Elshaarani, Tarig; Niu, Yongwu; Chen, Qihe

doi:10.1039/c9ra00344d

Cited by 24 publications

(16 citation statements)

References 87 publications

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“…The SEM images confirm the attachment of ZnO NPs on the bacterial cell surface and the subsequent disturbance to the integrity of bacterial cell membrane, which resulted in cell wrinkling and distortion. Similar findings were reported in the treatment of ZnO NPs, which caused cell membrane damage in E. coli ( Arakha et al, 2015 ), cell shrinkage in E. coli and S. enterica ( Bakur et al, 2019 ), membrane distortion, membrane blebbing, and leakage of cellular contents of E. coli and P. mirabilis ( Maruthupandy et al, 2018 ).…”

Section: Resultssupporting

confidence: 83%

Remedial Aspect of Zinc Oxide Nanoparticles Against Serratia Marcescens and Enterococcus Faecalis

et al. 2022

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Zinc oxide nanoparticles (ZnO NPs) have been widely used in biomedical applications due to their high biocompatibility and low toxicity to humans. The present work aimed to investigate the antibacterial effects of different concentrations of ZnO NPs on two opportunistic pathogens, Serratia marcescens and Enterococcus faecalis. The surface interaction between nanoparticles and bacterial cell wall, and the subsequent morphological alterations on the bacterial surface, were examined through Fourier transform infrared spectroscopy and scanning electron microscope. The energy dispersive X-ray analysis was used to confirm the elemental composition of ZnO NPs and the cellular accumulation of ZnO NPs in bacteria. The growth-inhibitory test demonstrated a dose-dependent growth inhibitory effect of ZnO NPs against both the test bacteria, as the higher concentration of nanoparticles caused the higher bacterial growth inhibition. The results showed that ZnO NPs caused a higher growth inhibition (63.50 ± 2.50%) on the Gram-positive bacterium E. faecalis compared to the Gram-negative bacterium S. marcescens (51.27 ± 4.56%). Fourier transform infrared spectrum revealed the possible involvement of hydroxyl, carboxyl, amides, methylene, and phosphate groups from the biomolecules of bacterial cell wall such as proteins, carbohydrates, lipids, and phospholipids in the interaction of ZnO NPs on bacterial cell surface. Energy dispersive X-ray analysis showed the higher accumulation of ZnO NPs in E. faecalis than S. marcescens analogous to the bacterial growth inhibition. Scanning electron microscopy images confirmed the antibacterial properties of ZnO NPs, showing the loss of integrity of cell membrane and distortion of bacterial cells. Hence, the potential of ZnO NP as an antibacterial agent against S. marcescens and E. faecalis has been confirmed.

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Section: Resultssupporting

confidence: 83%

Remedial Aspect of Zinc Oxide Nanoparticles Against Serratia Marcescens and Enterococcus Faecalis

et al. 2022

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“…However, their UV-C mediated counterparts showed slightly less inhibition. Bakur et al [58] reported similar level of anti-diabetic activities of biogenic bimetallic Ag-ZnONPs in a concentration-dependent manner. Our study shows the promise of green NPs as an effective drug in managing diabetes (Figure 14A).…”

Section: Anti-diabetic and Anti-glycation Activities Of Green Synthesized Agnps Znonps And Bimetallic Ag-znonpsmentioning

confidence: 82%

Light Tailoring: Impact of UV-C Irradiation on Biosynthesis, Physiognomies, and Clinical Activities of Morus macroura-Mediated Monometallic (Ag and ZnO) and Bimetallic (Ag–ZnO) Nanoparticles

Anjum

Khan

Qamar

et al. 2021

IJMS

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A nano-revolution based on the green synthesis of nanomaterials could affect all areas of human life, and nanotechnology represents a propitious platform for various biomedical applications. During the synthesis of nanoparticles, various factors can control their physiognomies and clinical activities. Light is one of the major physical factors that can play an important role in tuning/refining the properties of nanoparticles. In this study, biocompatible monometallic (AgNPs and ZnONPs) and bimetallic Ag–ZnONPs (0.1/0.1 and 0.1/0.5) were synthesized under UV-C light irradiation from the leaf extract of Morus macroura, which possesses enriched TPC (4.238 ± 0.26 mg GAE/g DW) and TFC (1.073 ± 0.18 mg QE/g DW), as well as strong FRSA (82.39%). These green synthesized NPs were evaluated for their anti-diabetic, anti-glycation, and biocompatibility activities. Furthermore, their anti-cancerous activity against HepG2 cell lines was assessed in terms of cell viability, production of reactive oxygen/nitrogen species, mitochondrial membrane potential, and apoptotic caspase-3/7 expression and activity. Synthesized NPs were characterized by techniques including ultraviolet-visible spectroscopy, SEM, EDX, FTIR, and XRD. UV-C mediated monometallic and bimetallic NPs showed well-defined characteristic shapes with a more disperse particle distribution, definite crystalline structures, and reduced sizes as compared to their respective controls. In the case of clinical activities, the highest anti-diabetic activity (67.77 ± 3.29% against α-amylase and 35.83 ± 2.40% against α-glucosidase) and anti-glycation activity (37.68 ± 3.34% against pentosidine-like AGEs and 67.87 ± 2.99% against vesperlysine-like AGEs) was shown by UV-C mediated AgNPs. The highest biocompatibility (IC50 = 14.23 ± 1.68 µg/mL against brine shrimp and 2.48 ± 0.32% hemolysis of human red blood cells) was shown by UV-C mediated ZnONPs. In the case of anti-cancerous activities, the lowest viability (23.45 ± 1.40%) with enhanced ROS/NOS production led to a significant disruption of mitochondrial membrane potential and greater caspase-3/7 gene expression and activity by UV-C mediated bimetallic Ag–ZnONPs (0.1/0.5). The present work highlights the positive effects of UV-C light on physico-chemical physiognomies as well as the clinical activities of NPs.

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“…Our previous researches also revealed that MEL-A has significantly inhibited the growth of Bacillus cereus [12] and Staphylococcus aureus [13] . Expect for its intrinsic capacity, MELs have been a key part of nanoparticles as emulsifier, exhibiting potent inhibitive effect on pathogens [30] , [31] , [32] . However, the abuse of antibiotics resulted in the emergence of methicillin-resistant Staphylococcus aureus (MRSA), which can survive in severe environment and convey a novel challenge to anti-infective treatments [33] .…”

Section: Discussionmentioning

confidence: 99%

Synergistic antibacterial and antibiofilm effects of ultrasound and MEL-A against methicillin-resistant Staphylococcus aureus

Lou

Wei

Zhang

et al. 2021

Ultrasonics Sonochemistry

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Comparative study of antidiabetic, bactericidal, and antitumor activities of MEL@AgNPs, MEL@ZnONPs, and Ag–ZnO/MEL/GA nanocomposites prepared by using MEL and gum arabic

Abstract: MEL@AgNPs, MEL@ZnONPs, and Ag–ZnO/MEL/GA nanocomposites were successfully prepared by using mannosylerythritol lipids (MEL) and gum arabic.

Cited by 24 publications

References 87 publications

Remedial Aspect of Zinc Oxide Nanoparticles Against Serratia Marcescens and Enterococcus Faecalis

Remedial Aspect of Zinc Oxide Nanoparticles Against Serratia Marcescens and Enterococcus Faecalis

Light Tailoring: Impact of UV-C Irradiation on Biosynthesis, Physiognomies, and Clinical Activities of Morus macroura-Mediated Monometallic (Ag and ZnO) and Bimetallic (Ag–ZnO) Nanoparticles

Synergistic antibacterial and antibiofilm effects of ultrasound and MEL-A against methicillin-resistant Staphylococcus aureus

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