Comparative study of antihypertensive and antioxidant effects of clove and metformin on renal dysfunction in streptozotocin-induced diabetic rats

Guenzet, Akila; Krouf, Djamil; Dida, Nawal; Saadia, Berzou

doi:10.1016/j.phanu.2018.01.001

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…The finding acquired from some studies represented that clove contains the fundamental therapeutic properties such as antibacterial, antifungal, antiviral, antifungal, anti-parasitic, anti-vomiting, anti-inflammatory, antispasmodic, anti-mutagenic, and antioxidant. It is recognized that the nephroprotective impact of clove, as a potent antioxidant, is the result of eliminating a variety of free radicals and metal chelating potency (11,12).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative impact of hydroalcoholic extract of Clove buds (Syzygium aromaticum) on contrast-induced acute kidney injury; an experimental histopathological study

et al. 2019

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Introduction: The administration of iodinated contrast medium is extensive in various imaging techniques including coronary angiography. Objectives: The present investigation was designed to examine the ameliorative effect of clove buds (Syzygium aromaticum) on contrast-induced acute kidney injury (CI-AKI) in rats Materials and Methods: Forty male Wistar rats with a mean body weight of 200-250 g were studied. Rats randomly assigned into four groups, 10 rats for each; Group 1; normal rats (control group; sham group); they did not receive any drugs. Group 2; rats were received 10 mL/kg as a single dose of iodixanol (contrast media) by intravenous (IV) injection. Group 3; rats received 10 mg/kg clove by intraperitoneal (IP) injection for three days, while in day forth, they received a single dose of iodixanol (10 mL/kg). Group 4; rats of this group first received a single dose of iodixanol (10 mL/ kg). Then rats treated by clove (10 mg/kg) by intraperitoneal (IP) injection for three days (days 2, 3 and 4th). Kidney sections were examined for degeneration, flattening, and necrosis of renal tubular cells and also dilatation of tubular lumen. Results: We found a significant difference between groups regarding the sum of injury (degeneration, flattening, necrosis and dilatation). A significant difference in types of injury (degeneration, flattening, necrosis and dilatation) among the groups (P=0.001) was seen too. We detected a significant difference between groups II (contrast media) and III (rats pretreated by clove; P<0.001). Accordingly, we detected a significant difference between groups II (contrast media) and IV (rats post-pone treated by Clove buds; P<0.001) too. There was not a significant difference between groups of III and IV (P> 0.05). Conclusion: In this animal study, we found that post-pone treatment of clove was as effective as pretreatment to mitigate the injury induced by contrast media.

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Section: Introductionmentioning

confidence: 99%

Ameliorative impact of hydroalcoholic extract of Clove buds (Syzygium aromaticum) on contrast-induced acute kidney injury; an experimental histopathological study

et al. 2019

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The chemical and pharmacological basis of cloves (Syzygium aromaticum (L.) Merr. & L.M.Perry) as potential therapy for type 2 diabetes and associated diseases

Habtemariam

2019

Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases

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Antihypertensive activity of Polyherbal Siddha Formulation Veppampoo Mathirai – A Review

Chitra

2022

RJPT

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Hypertension commonly termed as High blood pressure is a chronic disorder characterized by systolic >140mm Hg and diastolic >90mm Hg. The prevalence of Hypertension is increasing year by year globally as well as in India. Inadequate treatment of hypertension leads to complications such as congestive cardiac failure, stroke, kidney disease and blindness. Conventional hypertensives that have been in use are associated with side effects. Traditional medical systems which are having herbal plants as their formulations plays an important role in reducing high blood pressure with minimizing side effects. There is an increase in the use of herbal therapies to treat non communicable disease is on the rise worldwide. Siddha, one of the traditional medical systems of India, practiced mostly in south India had many formulations for Hypertension. One among them is veppampoo mathirai, a polyherbal tablet formulation, which had been in use, is found to be effective for hypertension. In this regard, this review focuses on the proven scientific antihypertensive related activities of hypertension exhibited by each ingredient of veppampoo mathirai.

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Comparative study of antihypertensive and antioxidant effects of clove and metformin on renal dysfunction in streptozotocin-induced diabetic rats

Cited by 3 publications

References 48 publications

Ameliorative impact of hydroalcoholic extract of Clove buds (Syzygium aromaticum) on contrast-induced acute kidney injury; an experimental histopathological study

Ameliorative impact of hydroalcoholic extract of Clove buds (Syzygium aromaticum) on contrast-induced acute kidney injury; an experimental histopathological study

The chemical and pharmacological basis of cloves (Syzygium aromaticum (L.) Merr. & L.M.Perry) as potential therapy for type 2 diabetes and associated diseases

Antihypertensive activity of Polyherbal Siddha Formulation Veppampoo Mathirai – A Review

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