Comparative study of antimicrobial action of aloe vera and antibiotics against different bacterial isolates from skin infection

Abstract

Aloe vera is reputed to have medicinal properties. For centuries, it has been used for an array of ailments such as mild fever, wounds and burns, gastrointestinal disorders, diabetes, sexual vitality and fertility problems to cancer, immune modulation, AIDS and various skin infections. In present study, antibacterial activity of aloe vera gel extracts was tested against some common skin infection pathogens, that is, Escherichia coli, Shigella, Salmonella spp. and Staphylococcus aureus all were recorded positive. Antibiotic resistance and susceptibility pattern of above isolates were also studied against 10 clinically significant antibiotics (ampicillin [AMC], amoxicillin, augmentin, cefotaxime, ceftazidime [CAZ], cefuroxime [CXM], ciprofloxaci, tetracycline, cefpodoxime and imipenem). AMC and CXM were found to be most effective antibiotic followed by CXM with highest efficacy against Gram‐negative bacteria. In case of CAZ showed highest efficacy was showed against Gram‐positive bacteria. Aloe vera leave gel was extracted with four different solvent‐like aloe vera leaf extract, root extract, leaf ethanol extract and root ethanol extract; however, Gram‐negative as well Gram‐positive isolates was found highest susceptibility with aloe leaf and aloe root ethanol extract. Moderate sensitivity observed with aloe leaf extract and aloe root extract against both Gram‐positive as well as Gram‐negative bacterial isolates. This result showed that ethanol extracts of aloe vera both leaf and root can be used alongside conventional antibiotics to fight agents of infections that are so prevalent in the skin infection.

Current scenario of traditional medicines in management of diabetic foot ulcers: A review

“…Aloe vera root and leaf ethanol extracts exhibited good antibacterial activity with a zone of inhibition of > 13 mm at a concentration of 30 mg[ 83 ]. Arbab et al [ 84 ] also concluded that ethanol extracts are more efficacious than conventional extracts. Antifungal activity was noted against Fusarium and Aspergillus [ 83 ].…”

Antimicrobial drug resistance against Escherichia coli and its harmful effect on animal health

“…Bacterial resistance to antibiotics is increasingly becoming a concern to animal health. Currently used antibiotic agents fail to end many bacterial infections due to super‐resistant strains (Arbab et al., 2021d). The use and misuse of antimicrobial drugs accelerate the emergence of drug‐resistant strains.…”

Screening of Bio-Active Components of Egyptian Aloe vera Herb as Antimicrobial and Antioxidant Agents

“…compared to a prior study (Safia Arbab et al, 2021) that was carried out in China. Our current investigation revealed stronger antioxidant and greater germicide activeness than standard ones, contrary to the earlier study which claimed that the bioactive components of Aloe vera had less antioxidant and antimicrobial effects than standard antioxidants and antimicrobial agents.…”

“…(IV) Bacteria actively export medicine via the employment of a multi-drug resistance pump (Metting Patricia J, 2019). The multidrug resistance pump imports protons and, in an exchangekind reaction, exports a lot of overseas molecules such as quinolones antibiotics( Safia Arbab et al, 2021). In the present study, we aimed toward looking for a new natural Aloe vera herb augmenting antimicrobial and antioxidant activities to defend in opposition to distinctive deadly infections and to avert carcinogenicity thru minimizing DNA harm via way of means of dangerous oxidizing agents consisting of gamma radiation and others.…”