Comparative Study of Antioxidant Activity from some Egyptian Plants and Phytochemical Composition

Rashed, Khaled; Güder, Aytaç

doi:10.3923/rjmp.2015.146.159

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…However, currently available tyrosinase inhibitors are constrained by toxicity and are less effective in inhibiting the tyrosinase enzyme. The constant search for better inhibitors from natural sources hopefully free from harmful side effects (Rashed et al, 2016), one of which is natural herbal plants. The community has carried out the use of natural materials for a long time because they contain many compounds that are efficacious in medicine, known as phytochemical compounds, which are natural groups of compounds that can be used to maintain health.…”

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confidence: 99%

Antioxidant Activity and Tyrosinase Inhibitor of Red Betel Leaf Extract

Weni,

Safithri

2023

IJAR

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Red betel leaf (Piper Crocatum) contains flavonoids, tannins, steroids, and alkaloids, known to act as antioxidants. This study aimed to determine the antioxidant activity of red betel leaf extract. The solvents used for the extraction process are ethanol and n-hexane. The thiobarbituric acid (TBA) method was used to determine antioxidant activity. The results showed that the extract of 200 ppm inhibited fatty acid oxidation by 52.13%. No significant difference (α = 0.05) inhibition of unsaturated fatty acids oxidation between the sample and α-tocopherol at 200 ppm. The ethanol extract of red betel can inhibit the tyrosinase enzyme higher than the n-hexane extract of red betel, as seen from the IC50 value of the ethanol extract of red betel of 1655 ppm, while the IC50 value of n-hexane of red betel is 3090.56 ppm.

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Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and Tyrosinase Inhibitor of Red Betel Leaf Extract

Weni,

Safithri

2023

IJAR

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African natural products with potential antioxidants and hepatoprotectives properties: a review

et al. 2016

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Free radicals are highly reactive molecules generated during oxidation reactions which in turn initiate chain reactions resulting to cellular damage. There is substantial evidence implicating free radicals especially reactive oxygen species (ROS) in the etiology of more than one hundred degenerative disorders in humans including, arthritis, atherosclerosis, ischemia and reperfusion injury of many tissues, gastritis, diabetics, central nervous system injury, acquired immunodeficiency syndrome (AIDS) and cancer. Scientific evidence postulates that bioactive compounds especially from natural products are capable of providing protection against free radicals. Consequently, few decades have witnessed a surfeit of research geared towards validating the antioxidant and hepatoprotective potential of the natural products. In this review, African natural products whose antioxidants activities were scientifically validated either in their crude extracts and/or derived products have been discussed. A total 1076 plants species representing 287 family, 132 isolated compounds and 7 insect/mollusk secreation were found. The plant species from the following families; Fababceae, Asteraceae, Lamiaceae, Moraceae, Euphorbiaceae, Combretaceae and Malvaceae have received more scientific attention than others. Analysis of the reports revealed that Combretum apiculatum, Telfaria occidentalis, Acalypha racemosa, Garcinia lucida were the most active plant extracts from African flora. The most active ROS-detoxifying phytochemicals were moracin T, U, S and R (84-87), oleanolic acid (54), 5,7,4′-trihydroxy-3,8,3′,5′-tetramethoxyflavone (89), 5,7,3′-trihydroxy-3,8,4′,5′-trimethoxyflavone (88), luteolin (3′,4′,5,7-tetrahydroxy flavone) (117) and genistein (4′,5,7-trihydroxyisoflavone) (116). The significant antioxidant potential demonstrated by some crude extracts and their constituent compounds render them good candidates for the development of new drugs. Although, the study of the mechanisms of actions as well as clinical validation of some of these isolated compounds is lacking. It is hoped that pertinent scientist and stakeholders will look further into some of these compounds for detailed authentification and subsequent commercialization.

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Comparative Study of Antioxidant Activity from some Egyptian Plants and Phytochemical Composition

Cited by 2 publications

References 30 publications

Antioxidant Activity and Tyrosinase Inhibitor of Red Betel Leaf Extract

Antioxidant Activity and Tyrosinase Inhibitor of Red Betel Leaf Extract

African natural products with potential antioxidants and hepatoprotectives properties: a review

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