Comparative study of artesunate, acts and their combinants on the hormonal parameters of the male guinea-pig

Obianime, A.W; Aprioku, J.S

doi:10.4314/njps.v24i2.52911

Cited by 12 publications

(14 citation statements)

References 16 publications

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“…The finding of decreased SOD and CAT activities in the liver of these animals as a result of drugs administration is not unexpected as both SOD and CAT are co-regulated in tissues in response to toxic assaults [66]. This result is consistent with the findings of other researchers [53,67,68].…”

Section: Alterations In Antioxidant Status and Biochemical Indices Fosupporting

confidence: 82%

“…Glutathione-S-tranferase is a family of multifunctional isozymes found in all eukaryotes, catalysing both glutathione dependent conjugation and reduction reactions [67]. One main function of GST is to catalyse the biotransformation of xenobiotics, including drugs detoxification in the mercapturic acid pathway, leading to the elimination of toxic compounds [69] and also acting as an antioxidant enzyme [70].…”

Section: Alterations In Antioxidant Status and Biochemical Indices Fomentioning

confidence: 99%

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Alterations in Antioxidant Status and Biochemical Indices Following Administration of Dihydroartemisinin-Piperaquine Phosphate (P-ALAXIN® )

Olayinka¹

2013

IOSR-JPBS

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Section: Alterations In Antioxidant Status and Biochemical Indices Fosupporting

confidence: 82%

Section: Alterations In Antioxidant Status and Biochemical Indices Fomentioning

confidence: 99%

Alterations in Antioxidant Status and Biochemical Indices Following Administration of Dihydroartemisinin-Piperaquine Phosphate (P-ALAXIN® )

Olayinka¹

2013

IOSR-JPBS

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“…A/L administration, however, generates free radicals that has the potential of causing cellular damage with evidence of both cardiotoxic, renal toxicity and other organ toxicity [1, 2]. The toxic potentials of A/L have been well reported in both humans [1, 2] and animal experiments using guinea-pigs [3–5]. …”

Section: Introductionmentioning

confidence: 99%

A dietary strategy for the management of artemether-lumefantrine-induced cardiovascular and renal toxicity

Asiedu-Gyekye

Seidu

N'Guessan

et al. 2016

BMC Complement Altern Med

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BackgroundUnsweetened natural cocoa has antimalarial properties. Unsweetened natural cocoa powder (UNCP), obtained as a result of the removal of cocoa butter from a cocoa bean protects against malaria episodes. Cocoa powder, which is prepared after removal of the cocoa butter, contains about 1.9 % theobromine and 0.21 % caffeine. Concomitant consumption of cocoa and artemether/lumefantrine (A/L) is a common practice in Ghana, West Africa. This study seeks to determine the elemental composition of UNCP and its protective effect on the heart and kidney against (A/L) administration.MethodsEnergy dispersive x-ray fluorescence spectroscopy was used to detect the quality and quantity of the elemental composition in UNCP. Thereafter, 30 nonmalarious male guinea pigs were divided into five groups of six animals each. One group was administered with 75 mg/kg body weight A/L only and another group distilled water (control group). The rest received 300 mg/kg, 900 mg/kg and 1500 mg/kg body weight UNCP for 14 days orally and A/L for the last 3 days (ie day 11 to day 14). Biochemical and histopathological examinations were carried out after euthanisation of the animals.ResultsA total of thirty-eight (38) micro and macro elements were detected with the ED-XRF. Macro elements like sodium (Na), magnesium (Mg), aluminium (Al), phosphorus (P), chlorine (Cl), potassium (K), calcium (Ca), manganese (Mn) and iron (Fe) and micro elements like chromium (Cr), copper (Cu), zinc (Zn), arsenic (As), and lead (Pb) were identified and evaluated. Biochemical analysis revealed increases in HDL levels (p>0.05) while there were decreases in LDL levels (p>0.05), creatine kinase and AST levels (P<0.05) in animals that received UNCP compared to A/L only administered group. Urea levels reduced significantly by 53 % (p<0.05) in group that received 1500 mg/kg UNCP. Histopathological examinations of the heart and kidney buttressed the protective effects of cocoa administration.ConclusionThe percentage of recommended daily allowance of UNCP for chromium is 3750 % for men and 5250 % for women while % RDA for copper corresponds to 103.6 % in both sexes. UNCP proved to possess cardioprotective and renoprotective potential during artemether-lumefantrine administration.

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“…The munumbicin D was reported as more powerful than chloroquine, the gold-standard antimalarial drug. [50] Furthermore, munumbicins B, C and D did not cause any detectable lysis of human red blood cells. But these compounds were not effective against human pathogenic fungi.…”

Section: Munumbicinsmentioning

confidence: 99%

Endophytic bacteria as a source of novel antibiotics: An overview

Christina¹,

Christapher²,

Bhore³

2013

Phcog Rev

115

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World human population is increasing with an alarming rate; and a variety of new types of health issues are popping up. For instance, increase in number of drug-resistant bacteria is a cause of concern. Research on antibiotics and other microbial natural products is pivotal in the global fight against the growing problem of antibiotic resistance. It is necessary to find new antibiotics to tackle this problem. The use of therapeutic plant species in traditional medicine is as old as mankind; and currently, it is strongly believed that all types of plant species across the plant kingdom do harbour endophytic bacteria (EB). The natural therapeutic compounds produced by EB do have several potential applications in pharmaceutical industry. The EB derived natural products such as Ecomycins, Pseudomycins, Munumbicins and Xiamycins are antibacterial, antimycotic and antiplasmodial. Some of these natural products have been reported to possess even antiviral (including Human Immunodeficiency Virus (HIV)) properties. Therefore, to deal with increasing number of drug-resistant pathogens EB could serve as a potential source of novel antibiotics.

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Comparative study of artesunate, acts and their combinants on the hormonal parameters of the male guinea-pig

Cited by 12 publications

References 16 publications

Alterations in Antioxidant Status and Biochemical Indices Following Administration of Dihydroartemisinin-Piperaquine Phosphate (P-ALAXIN® )

Alterations in Antioxidant Status and Biochemical Indices Following Administration of Dihydroartemisinin-Piperaquine Phosphate (P-ALAXIN® )

A dietary strategy for the management of artemether-lumefantrine-induced cardiovascular and renal toxicity

Endophytic bacteria as a source of novel antibiotics: An overview

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