Comparative Study of Buccoadhesive Formulations and Sublingual Capsules of Nifedipine

Save, Tanuja; Shah, Meena U.; Ghamande, A. R; Venkitachalam, Padma

doi:10.1111/j.2042-7158.1994.tb03776.x

Cited by 26 publications

(7 citation statements)

References 6 publications

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“…Mucoadhesive gels, pastes, and hydrogel-forming films are also mostly used for local topical delivery or to form protective layers over wounds, for example to treat ulcers and sores [ 17 ]. Gels have also been trialled for the systemic delivery of analgesics [ 18 ] and anti-hypertensives [ 19 ]. Buccal tablets and lozenges are used for both topical and systemic delivery and may include mucoadhesives.…”

Section: Oral Mucosamentioning

confidence: 99%

Mucoadhesive Electrospun Fibre-Based Technologies for Oral Medicine

et al. 2020

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Oral disease greatly affects quality of life, as the mouth is required for a wide range of activities including speech, food and liquid consumption. Treatment of oral disease is greatly limited by the dose forms that are currently available, which suffer from short contact times, poor site specificity, and sensitivity to mechanical stimulation. Mucoadhesive devices prepared using electrospinning offer the potential to address these challenges by allowing unidirectional site-specific drug delivery through intimate contact with the mucosa and with high surface areas to facilitate drug release. This review will discuss the range of electrospun mucoadhesive devices that have recently been reported to address oral inflammatory diseases, pain relief, and infections, as well as new treatments that are likely to be enabled by this technology in the future.

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Section: Oral Mucosamentioning

confidence: 99%

Mucoadhesive Electrospun Fibre-Based Technologies for Oral Medicine

et al. 2020

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“…The volunteers were instructed to press the discs against the gingival mucosa above the canine tooth for 60 s (16). The discs were observed for 8 h. Then, the discs which remained in the buccal cavity were removed and dissolved in 50 mL phosphate buffer pH 6.8.…”

Section: In Vivo Evaluation Of Mucoadhesive Performance Of Fluconazolmentioning

confidence: 99%

“…Excipients like polyethylene glycol (PEG 6000) and mannitol were used to develop an erodible buccal disc to ensure drug release in the mouth. It was reported that PEG 6000 could increase the release of drugs from the matrix and that mannitol had a sweet taste, a good mouth feel, negative heat of solution, and dissolutionenhancing properties (16).…”

Section: In Vitro Release Of Fluconazole From Discs Prepared By Direcmentioning

confidence: 99%

Design and In Vitro/In Vivo Evaluation of Novel Mucoadhesive Buccal Discs of an Antifungal Drug: Relationship Between Swelling, Erosion, and Drug Release

2008

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Abstract. Two groups of fluconazole mucoadhesive buccal discs were prepared: (a) Fluconazole buccal discs prepared by direct compression containing bioadhesive polymers, namely, Carbopol 974p (Cp), sodium carboxymethyl cellulose (SCMC), or sodium alginate (SALG) in combination with hydroxypropyl methylcellulose (HPMC) or hydroxyethyl cellulose (HEC). (b) Fluconazole buccal discs prepared by freeze drying containing different polymer combinations (SCMC/HPMC, Cp/HPMC, SALG/HPMC, and chitosan/SALG). The prepared discs were evaluated by investigating their release pattern, swelling capacity, mucoadhesion properties, and in vitro adhesion time. In vivo evaluation of the buccal disc and in vivo residence times were also performed. Fluconazole salivary concentration after application of fluconazole buccal systems to four healthy volunteers was determined using microbiological assay and high-performance liquid chromatography. SCMC/HPMC buccal disc prepared by direct compression could be considered comparatively superior mucoadhesive disc regarding its in vitro adhesion time, in vivo residence time, and in vitro/in vivo release rates of the drug. Determination of the amount of drug released in saliva after application of the selected fluconazole disc confirmed the ability of the disc to deliver the drug over a period of approximately 5 h and to reduce side effects and possibility of drug interaction encountered during systemic therapy of fluconazole, which would be beneficial in the case of oral candidiasis.

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“…Many pharmaceutical buccal delivery bases are made of synthetic polymers, e.g. copolymers of acrylic acid, polyethylene glycol and monomethylether monomethacrylate (3,4), copolymer of polyisobutylene and polyisoprene (5,6), polyvinyl pyrrolidone (7,8), and eudragit (9)(10)(11). Blooming use of these polymers has caused serious environmental problems and petroleum as an important resource for originating such polymers is limited.…”

Section: Introductionmentioning

confidence: 99%