Comparative Study of Clonidine Vs Dexmedetomidine for Hemodynamic Stability and Postoperative Analgesia during Laproscopic Surgery

Gautam, Prabhat

doi:10.21276/ijcmr.2019.6.1.20

Cited by 3 publications

(3 citation statements)

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“…Group I patients received 0.9% normal saline (placebo), group II patients received 0.5 µg/kg of dexmedetomidine and group III patients received 3 µg/kg of or clonidine. Pooja et al, [10] in their study group 1 received 2 µg/kg of clonidine and group 2 patients received 1 µg/kg of dexmedetomidine Results showed that the mean scores of SBP were higher in group 1 among both the groups over the periods. The mean scores of DBP in both groups was similar over the periods with slightly being higher in Group 1 especially after 30 min to till end as compared to Group 2.…”

Section: Discussionmentioning

confidence: 91%

A Comparative Study of Dexmedetomidine and Clonidine for Attenuation of Hemodynamic Response during Laryngoscopy and Intubation

Gupta¹,

Singhal²

2020

AAN

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Background: The present study was conducted to compare dexmedetomidine and clonidine for attenuation of hemodynamic response during laryngoscopy and intubation. Subjects and Methods: Group I patients received 0.9% normal saline (placebo), group II patients received 0.5 µg/kg of dexmedetomidine and group III patients received 3 µg/kg of or clonidine. Each group had 15 patients. Results: The mean age in group I was 28.2 years, in group II was 32.1 years and in group III was 33.2 years, mean weight was 61.2 years, in group II was 60.4 years and in group III was 62.1 years, height was 156.2 cm, in group II was 157.1 cm and in group III was 152.8 cm. There were 8 males and 7 females in group I, 6 males and 9 females in group II and 7 males and 8 females in group III. The mean SBP (mm Hg) in group I was 121.4 and in group II was 122.6, and in group III was 127.4, DBP (mm Hg) was 76.2 in group I, 78.4 in group II and 78.2 in group III. MAP (mm Hg) was 86.7 in group I, 93.2 in group II and 92.5 in group III. HR (bpm) was 74.2 in group I, 78.4 in group II and 77.3 in group III. % oxygen saturation was 98.2in group I, 98.5 in group II and 97.9 in group III. The difference was non- significant (P> 0.05). Conclusion: Authors found that both groups were equally effective in causing attenuation of hemodynamic response to endotracheal intubation.

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Section: Discussionmentioning

confidence: 91%

A Comparative Study of Dexmedetomidine and Clonidine for Attenuation of Hemodynamic Response during Laryngoscopy and Intubation

Gupta¹,

Singhal²

2020

AAN

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“…Dexmedetomidine attenuates systolic blood pressure changes during pneumoperitoneum more effectively than clonidine when administered intravenously before induction. 12 Basar et al, 13 used 0.5 mcg/kg dexmedetomidine as a single pre-operative dose and found blunting of hemodynamic responses. Bhattacharjee et al, 14 infused 0.2 mcg/kg/h dexmedetomidine and found significantly less MAP and heart rate throughout the period of pneumoperitoneum.…”

Section: Discussionmentioning

confidence: 99%

“…The attenuation of hemodynamic responses was better controlled with dexmedetomidine than clonidine 10. Other studies11,12 also report about better control of heart rate in patients receiving dexmedetomidine compared with clonidine during intubation and pneumoperitoneum.…”

mentioning

confidence: 84%

Comparison of efficacy between intravenous clonidine and dexmedetomidine as pre-medication in attenuating hemodynamic stress responses during laparoscopic cholecystectomy

Diptimay Majumder,

Susanta Kumar Halder,

Swarup Datta

et al. 2023

Asian J Med Sci

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Background: Laparoscopic cholecystectomy is a commonly performed surgery and stable intraoperative hemodynamic status is desirable during pneumoperitonium. Clonidine and dexmedetomidine (alpha-2 adrenergic agonist) were used in this study to attenuate the stress response of pneumoperitoneum because alpha-2 adrenergic agonists help in the attenuation of neuroendocrine and hemodynamic responses to surgery and anesthesia, due to its sympatholytic action. Aims and Objectives: The aims and objectives of the study are to conduct a comparative evaluation of clonidine and dexmedetomidine as pre-anesthetic medication for the attenuation of hemodynamic changes during laparoscopic cholecystectomy surgeries. Materials and Methods: Eighty patients of either sex, aged 20–50 years, complying to the American Society of Anesthesiologists physical status I-II, scheduled for elective laparoscopic cholecystectomy under general anesthesia were divided into two equal groups to receive either clonidine 1 mg/kg (Group-C, n=40) or dexmedetomidine 1 mg/kg (Group-D, n=40), both injected through intravenous route as 15 mL volume with normal saline. Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, and SpO2 were measured before and after giving the study drugs, before and immediately after pneumoperitoneum, and then, at 10, 20, 30, 40, and 50 min of pneumoperitoneum. Results: Statistically significant difference was observed in heart rate in the dexmedetomidine group constantly since giving study drug, immediately after the creation of pneumoperitoneum, and then, 10, 20, 30, 40, and 50 min after pneumoperitoneum. Systolic, diastolic, and mean blood pressures were found to be significantly lower in Group D (except after administering study drug), immediately after creating pneumoperitoneum, and 10, 20, 30, 40, and 50 min after pneumoperitoneum. Conclusion: Dexmedetomidine as pre-medication is more efficacious in attenuating hemodynamic stress responses in laparoscopic cholecystectomy surgeries compared to clonidine as pre-medication.

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Effect of Magnesium Sulfate and Clonidine in Attenuating Hemodynamic Response in Laparoscopic Cholecystectomy -a Clinical Comparative Study

Dutta

Pathak

2021

PIJR

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INTRODUCTION - Laryngoscopy and tracheal intubation invariably causes hypertension and tachycardia and subsequent pneumoperitoneum and changes in patient position required during laparoscopic surgeries add to the insult. In patients with cardiovascular co-morbididities, such alterations can cause severe life threatening situations 1 perioperatively .Various drugs have been tried to attenuate these effects and in this regard,clonidine,and magnesium sulfate have shown promising results. AIM- This study was aimed at comparing the efficacy of clonidine and magnesium sulphate in attenuating the hemodynamic responses to laryngoscopy, intubation and pneumoperitoneum, assessed in terms of heart rate, systolic blood pressure,diastolic blood pressure and mean arterial pressure. INCLUSION CRITERIA:Patients between age 18-60 years, of both sexes, ASA grade I&II and scheduled for elective laparoscopic cholecystectomy under general anesthesia. EXCLUSION CRITERIA:Refusal to informed consent,anticipated difficult airway,ASA grade III&IV,history of allergy to study drug, pregnant and lactating mother, any disorders of cardiovascular system, respiratory system, renal system, hepatic and neuromuscular condition. METHODS-:A randomized prospective study was conducted in Silchar Medical College and Hospital, Silchar, and 80 patients were randomly allocated to two groups of 40 patients each.One group received clonidine 1.5mcg/kg whereas other group received MgSO4 50mg/kg.HR,SBP,DBP,and MAP were recorded at baseline,after infusion of the study drug, just before intubation, after intubation at 1min,3mins,and5mins, after pneumoperitoneum at 5min,10min,20min,and 30min.All analyses were done by using two tailed test p-value. RESULTS: The mean values in HR,SBP, and MAP values at at various intervals were statistically significant (p<0.05) in clonidine group when compared to MGSO4 group. CONCLUSION: Clonidine was found more effective than MGSO4 during laryngoscopy and intubation while both were equally effective during pneumoperitoneum which correlated with other similar studies.

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Comparative Study of Clonidine Vs Dexmedetomidine for Hemodynamic Stability and Postoperative Analgesia during Laproscopic Surgery

Cited by 3 publications

References 10 publications

A Comparative Study of Dexmedetomidine and Clonidine for Attenuation of Hemodynamic Response during Laryngoscopy and Intubation

A Comparative Study of Dexmedetomidine and Clonidine for Attenuation of Hemodynamic Response during Laryngoscopy and Intubation

Comparison of efficacy between intravenous clonidine and dexmedetomidine as pre-medication in attenuating hemodynamic stress responses during laparoscopic cholecystectomy

Effect of Magnesium Sulfate and Clonidine in Attenuating Hemodynamic Response in Laparoscopic Cholecystectomy -a Clinical Comparative Study

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