Comparative Study of Clopidogrel Using PVA and Cutina

Abstract

The solubility and bioavailability of a drug is very important while preparing a formulation.BCS class-II drugs like clopidogrel have the problem of poor bioavailability because of less solubility. So many novel techniques were available to improve the solubility aspects of drug among which solid lipid nanoparticles is a promising approach. In the current study attempts were made to formulate and evaluate clopidogrel loaded solid lipid nanoparticles by employing cutina as lipid and lecithin soya and PEG-400 and TWEEN-80 were used as surfactant systems. Different formulations were prepared and analyzed for drug content, entrapment efficiency, drug release studies. The selected formulations were analyzed with stability studies at two different conditions which is, room temperature and refrigerated conditions.