Comparative study of diagnostic efficacy of sputum and bronchoalveolar lavage fluid specimens in community-acquired pneumonia children treated with fiberoptic bronchoscopy

Wang, Le; Lu, Sukun; Guo, Yinghui; Liu, Jianhua; Wu, Peng; Yang, Shuo

doi:10.1186/s12879-023-08522-3

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…In China, this testing has not been routinely carried out in hospital, can be shipped to commercial biological companies, so it is not very convenient. Bronchoalveolar lavage fluid obtained from fiberoptic bronchoscopy can obtain pathogenic bacteria in the lower respiratory tract, and it is rarely contaminated by other bacteria, which is a valuable sampling material for pathogenic bacteria in clinical work ( 22 , 23 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: From oral infection to life-threatening pneumonia: clinical considerations in Nocardia infection from a case

Chen,

Wang,

Dong

et al. 2024

Front. Med.

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Nocardia is an anthropozoonotic bacteria that occurs widely in the natural environment. However, because it is a gram-positive aerobic opportunistic pathogen, it rarely occurs in patients with no prior history of immune function disease. Since the symptoms are nonspecific the diagnosis of Nocardia pneumonia is challenging. Previous studies have not reported that this anthropozoonotic bacteria colonizing the human body could cause severe pneumonia by gingival pain and pharyngeal discomfort. This case report describes a previously healthy 60-year-old female farmer who presented to the doctor with gingival pain and pharyngeal discomfort. She was treated with a dental cleaning and oral metronidazole. The patient rapidly progressed to breathing difficulties. Lung shadow was found by computerized tomography examination. The radiologist diagnosed pulmonary tuberculosis as image-based. Through laboratory examination and culture of pathogenic microorganisms in the sputum and blood of the patient, no obvious positive findings were found. The disease progressed rapidly to tracheal intubation ventilator assisted breathing. Subsequently, the patient underwent alveolar lavatory examination under endotracheal intubation fiberbronchoscopy, and the culture of alveolar lavage fluid indicated Nocardia. According to this result, the patient’s disease was quickly controlled after selecting the targeted drug compound sulfamethoxazole and intravenous meropenem for treatment. In view of the reason for the high misdiagnosis rate due to the low positive rate of Nocardia culture in most cases, the clinical thinking of diagnosis and treatment from oral infection symptoms to fatal pneumonia reported in this case has certain clinical popularization and enlighten significance, not only improved the diagnosis and treatment of rare diseases, but also be reduced medical disputes.

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Section: Discussionmentioning

confidence: 99%

Case report: From oral infection to life-threatening pneumonia: clinical considerations in Nocardia infection from a case

Chen,

Wang,

Dong

et al. 2024

Front. Med.

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Impact of the Lung Microbiota on Development and Progression of Lung Cancer

Belaid,

Roméo,

Rignol

et al. 2024

Cancers

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The past several years have provided a more profound understanding of the role of microbial species in the lung. The respiratory tract is a delicate ecosystem of bacteria, fungi, parasites, and viruses. Detecting microbial DNA, pathogen-associated molecular patterns (PAMPs), and metabolites in sputum is poised to revolutionize the early diagnosis of lung cancer. The longitudinal monitoring of the lung microbiome holds the potential to predict treatment response and side effects, enabling more personalized and effective treatment options. However, most studies into the lung microbiota have been observational and have not adequately considered the impact of dietary intake and air pollutants. This gap makes it challenging to establish a direct causal relationship between environmental exposure, changes in the composition of the microbiota, lung carcinogenesis, and tumor progression. A holistic understanding of the lung microbiota that considers both diet and air pollutants may pave the way to improved prevention and management strategies for lung cancer.

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Comparative study of diagnostic efficacy of sputum and bronchoalveolar lavage fluid specimens in community-acquired pneumonia children treated with fiberoptic bronchoscopy

Cited by 2 publications

References 30 publications

Case report: From oral infection to life-threatening pneumonia: clinical considerations in Nocardia infection from a case

Case report: From oral infection to life-threatening pneumonia: clinical considerations in Nocardia infection from a case

Impact of the Lung Microbiota on Development and Progression of Lung Cancer

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