Comparative study of efficacy and safety of fractional CO2 laser and microneedling fractional radiofrequency (MnRF) in the treatment of striae distensae

Ghosh, Avik W.; Ravindranath, Mithila; Mallya, Rashmi R.

doi:10.18231/j.ijced.2020.056

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…17 Gosh et al also showed than 73.3% subjects with SD have family history of striae distensae. 18 It was assumed that there were gene expression involvement in fibroblast metabolism that code elastin, collagen, and fibronectin was lower compared to normal skin. 19 There is no single therapy that is truly effective in treating striae distensae.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of green tea (Camellia sinensis Linn) 3% extract cream on improvement of striae distensae

Ayuningsih,

Jusuf,

Putra

2024

F1000Res

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Background Striae distensae (SD) is a skin condition that frequently causes dermatological consultations and although asymptomatic, it may can cause itch and burning sensation. Green tea extract contains polyphenol, including flavanol, flavandiol, flavonoid, phenolic acid, amino acids and minerals which play a role in the repair of stretch marks through anti-inflammatory mechanism, increase collagen production, fibroblast proliferation, and skin hydration. Objective To determine the efficacy of green tea extract cream on striae distensae. Methods This is a pre-experimental clinical trial with a pretest-posttest design on 36 subjects with striae distensae. Diagnosis establishes through history taking and clinical evaluation. Imam Nelva Alviera (INA) score was used as SD severity before and after the application of the 3% green tea extract cream carried out at weeks 0, 2, 4, 6, and 8. Side effects and subjects’ satisfaction were also recorded. Cochran test was carried out to see the difference before and after treatment, with a p-value <0.05 considered significant. Results Majority of study subjects were 18–25 years (77.8%), had history of pregnancy (75%), had a history of menarche at the age of 12 years (27.8%) and all subjects had striae alba. There was significant decrement in INA score for striae distensae (p<0.001) after eight weeks administration of 3% green tea extract cream. Clinical improvement and no side effects were also noted. All subjects were satisfied. Conclusions The use of 3% green tea extract cream can improve the appearance of SD.

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Section: Discussionmentioning

confidence: 99%

Efficacy of green tea (Camellia sinensis Linn) 3% extract cream on improvement of striae distensae

Ayuningsih,

Jusuf,

Putra

2024

F1000Res

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A clinical and histopathological study comparing the efficacy and safety of carboxytherapy, platelet-rich plasma, and fractional carbon dioxide laser in the treatment of striae distensae

Eldawla,

El-Deen Yassin,

Al-Shandawely

et al. 2023

Egyptian Journal of Dermatology and Venereology

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Background Striae distensae (SD) are linear scars that develop in the areas of dermal damage owing to overstretching of the skin. No gold standard line of treatment has been determined. Objectives To compare the efficacy and safety of carboxytherapy, platelet-rich plasma (PRP), and fractional carbon dioxide (CO2) laser in the treatment of SD clinically and histopathologically. Patients and methods The study included 37 female patients with SD, aged 18–50 years. Complete history taking and general and dermatological examinations were performed. The study population was randomly divided into three groups: group A was treated with carboxytherapy, group B was treated with PRP, and group C was treated with fractional CO2 laser. The groups were treated each for six sessions with 3-week intervals and followed up after a month from the last treatment session. The session showing the beginning of improvement and the overall improvement were recorded in each group. Adverse effects, as well as the satisfaction of patient and dermatologist, were also evaluated and graded. The pretreatment and posttreatment histopathological changes in each group were evaluated and recorded according to a modified scoring system. Masson’s Trichrome staining was performed to evaluate the collagen content. Results In the present study, the highest ratio of the overall improvement was observed in group C followed by group B and group A. Histopathological improvement was observed in the three groups with different mechanisms according to the applied treatment. Fractional CO2 laser showed more histopathological improvement than the other treatment modalities. Conclusions The present study concluded that carboxytherapy, PRP, and fractional CO2 laser were clinically and histopathologically effective and safe treatment options for mild to severe SD. Fractional CO2 laser was more effective especially in cases of moderate to severe striae albae. Although it is an expensive treatment method, it resulted in a higher satisfaction rate between the patient and dermatologist with a good safety profile and tolerability.

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Comparative study of efficacy and safety of fractional CO2 laser and microneedling fractional radiofrequency (MnRF) in the treatment of striae distensae

Cited by 2 publications

References 8 publications

Efficacy of green tea (Camellia sinensis Linn) 3% extract cream on improvement of striae distensae

Efficacy of green tea (Camellia sinensis Linn) 3% extract cream on improvement of striae distensae

A clinical and histopathological study comparing the efficacy and safety of carboxytherapy, platelet-rich plasma, and fractional carbon dioxide laser in the treatment of striae distensae

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