Comparative Study of Enzyme-Linked Immunosorbent Assay and Radioimmunoassay Techniques in Determining Serum Placental Protein 14 Levels in Gynecologic Patients

Scherbakova, L. A.; Göcze, Péter M.; Olefirenko, G. A.; Than, G. N.; Szabò, D. G.; Петрунин, Д. Д.; Tatarinov, Yu. S.; Csába, I

doi:10.1159/000217714

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Elevated levels of PAMG-2 were demonstrated in serum of patients with ovarian and uterine malignancies [19,68,69]. Ovarian tumors also contain splicing variants of the mRNA [21].…”

Section: Tumorsmentioning

confidence: 99%

Glycodelins

Seppälä¹,

Bohn²,

Tatarinov³

1998

Tumor Biol

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Glycodelins are 28 to 30-kD glycoproteins synthesized in various glands, notably those of the male and female reproductive organs. Depending on the site of origin, the same protein backbone is glycosylated in different ways, yielding glycodelins with different biological actions. Thus, human endometrium-derived glycodelin-A is temporally expressed in the latter half of the menstrual cycle, consists of unique sialylated and fucosylated lacdiNAc oligosaccharide sequences, and inhibits sperm-egg binding. By contrast, glycodelin-S from seminal vesicles has no such oligosaccharide sequences and no contraceptive activity. Glycodelin-A also has potent immunosuppressive properties, and its chemically modified forms inhibit transmission of HIV in vitro. Studies are reviewed suggesting that glycoforms dictate the function of human glycodelins, and that some of the oligosaccharide recognition sites present in the human gametes and immune cells have converged.

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“…Elevated levels of PAMG-2 were demonstrated in serum of patients with ovarian and uterine malignancies [19,68,69]. Ovarian tumors also contain splicing variants of the mRNA [21].…”

Section: Tumorsmentioning

confidence: 99%

Glycodelins

Seppälä¹,

Bohn²,

Tatarinov³

1998

Tumor Biol

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Placental protein 13 (PP-13): effects on cultured trophoblasts, and its detection in human body fluids in normal and pathological pregnancies

et al. 2004

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Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation

et al. 2002

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Glycodelin is a glycoprotein that belongs to the lipocalin superfamily. Depending on glycosylation, glycodelin appears in various isoforms. In the uterus, glycodelin-A is the major progesterone-regulated glycoprotein secreted into uterine luminal cavity by secretory/decidualized endometrial glands. The other tissues expressing glycodelin include fallopian tubes, ovary, breast, seminal vesicle, bone marrow, and eccrine glands. Glycodelin-A potently and dose-dependently inhibits human sperm-egg binding, whereas differently glycosylated glycodelin-S from seminal plasma has no such effect. Absence of contraceptive glycodelin-A in the uterus during periovulatory midcycle is consistent with an open "fertile window." Glycodelin induced by local or systemic administration of progestogens may potentially reduce the fertilizing capacity of sperm in any phase of the menstrual cycle. Glycodelin also has immunosuppressive activity. Its high concentration at the fetomaternal interface may contribute to protection of the embryonic semiallograft. Besides being an epithelial differentiation marker, glycodelin appears to play a role in glandular morphogenesis, as transfection of glycodelin cDNA into a glycodelin-negative breast cancer cells resulted in formation of gland-like structures, restricted proliferation, and induction of other epithelial markers. These various properties, as well as the chemistry, biology, and clinical aspects of glycodelin, continue to be areas of active investigation reviewed in this communication.

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Comparative Study of Enzyme-Linked Immunosorbent Assay and Radioimmunoassay Techniques in Determining Serum Placental Protein 14 Levels in Gynecologic Patients

Cited by 3 publications

References 6 publications

Glycodelins

Glycodelins

Placental protein 13 (PP-13): effects on cultured trophoblasts, and its detection in human body fluids in normal and pathological pregnancies

Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation

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