Comparative study of four different types of intraperitoneal mesh prostheses in rats

Abstract

Purpose:To compare four types of mesh regarding visceral adhesions, inflammatory response and incorporation.Methods:Sixty Wistar rats were divided into four groups, with different meshes implanted intraperitoneally: polytetrafluoroethylene (ePTFE group); polypropylene with polydioxanone and oxidized cellulose (PCD); polypropylene (PM) and polypropylene with silicone (PMS). The variables analyzed were: area covered by adhesions, incorporation of the mesh and inflammatory reaction (evaluated histologically and by COX2 immunochemistry).Results:The PMS group had the lowest adhesion area (63.1%) and grade 1 adhesions. The ePTFE and PM groups presented almost the total area of their surface covered by adherences (99.8% and 97.7% respectively) The group ePTFE had the highest percentage of area without incorporation (42%; p <0.001) with no difference between the other meshes. The PMS group had the best incorporation rate. And the histological analysis revealed that the inflammation scores were significantly different.Conclusions:The PM mesh had higher density of adherences, larger area of adherences, adherences to organs and percentage of incorporation. ePTFE had the higher area of adherences and lower incorporation. The PMS mesh performed best in the inflammation score, had a higher incorporation and lower area of adherences, and it was considered the best type of mesh.

Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

“…Fuziy et al . 21 carried out an experimental study with rats and implanted one of four different types of meshes intraperitoneally. The meshes were made of PTFE-e, polypropylene with oxidized cellulose, polypropylene with silicone, and only polypropylene.…”

“…The histological analysis of the inflammatory tissue response was performed at the Department of Pathology of Universidade Federal de São Paulo, by a pathologist with experience on inflammatory responses and fibroplasia after the experimental implantation of synthetic meshes 15 , 16 , 20 , 21 . The sections stained with HE were examined using an Axio Scope.A1® (Carl Zeiss, Jena, Germany) optical microscope.…”