Comparative study of hematological parameters along with effect of chemotherapy and radiotherapy in different stages of breast cancer

Shrivastava, Swati; Singh, Neelima; Nigam, Akshay; Chandel, Sanjay Singh; Shrivastava, Reetika; Kumar, Sarvesh

doi:10.18203/2320-6012.ijrms20164569

Cited by 20 publications

(24 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our finding is in agreement with previous study report [39] (Shrivastava, et al, 2016). However, the finding from this study is at variance with a previous report in Babylon reported by Liqaa (2014) [18] which indicated a significant increase of platelets among breast cancer subjects.…”

Section: Discussionsupporting

confidence: 94%

“…This finding is in agreement with previous reports [36][37][38]. However, our finding is at variance with a previous report in India [39] where no significant difference was observed between TWBC counts of breast cancer subjects and controls. The discordance could be due to different testing methods used.…”

Section: Discussionsupporting

confidence: 92%

“…It is often used as an index for the diagnosis of anaemia. The decreased in PCV observed among breast cancer patients is consistent with findings in previous reports which showed that anaemia is a constant feature among breast cancer patients [39,40,43]. The anaemia seen in these patients may be due to the effect of chemotherapy and or anaemia due to chronic diseases.…”

Section: Discussionsupporting

confidence: 91%

“…Several studies have shown that anaemia is a frequent finding in cancer patients, occurring in >40% of cases [45][46][47]. Similarly, a study by Shrivrastava et al (2017) [39] has shown low level of haemoglobin and RBC count in breast cancer. A case control studies carried out by Akinsegun [40] on breast cancer found 58 out 100 of the cases to be anaemic.…”

Section: Discussionmentioning

confidence: 90%

“…Total leucocyte count, if elevated, predicts poorer prognosis [42] (Grim et al, 1985). Studies have shown of a remarkable increase in the white blood cell counts in breast cancer prior to chemotherapy [37,39]. Akinsegun [40] found the white blood cell count to be higher in patients when compared to controls.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Some full blood count parameters among women of African descent with breast cancer in Sokoto, North Western Nigeria

Osaro¹,

Me²,

Michael³

et al. 2018

J Pregnancy Reprod

View full text Add to dashboard Cite

Breast cancer is the most common female malignancy both in Nigeria and globally. The aim of this case-control study was to determine the changes in some haematological parameters among breast cancer patients in Sokoto, Nigeria. The study included a total of 46 breast cancer subjects (mean age 42.91 ± 5.83 years) visiting the Specialist Hospital, in Sokoto, North Western Nigeria. A total of 46 apparently healthy age-matched women were monitored as control. Some haematological (packed cell volume, total white blood cell count and platelet count) were analyzed using the auto-haematology analyzer (Genesis, HA6000). Breast cancer staging was determined using the TNM classification. Data were analyzed using SPSS 22.0 statistical package. A p-value ≤0.05 was considered significant in all comparisons. The result indicated that patients with breast cancer had a lower mean packed cell volume (29.20 ± 0.50 %) compared to controls (36.20 ± 0.42 %) (p=0.000). The mean total white blood cell count of patients was also statistically lower among breast cancer patients (3.91 ± 0.19×10 9 /l) compared to controls (4.38 ± 0.13×10 9 /l) (p=0.045). There were no statistically significant differences in the mean value of platelet counts of breast cancer patients (197 ± 5.06×10 9 /l) and controls (207 ± 5.84×10 9 /l) (p=0.217). Newly diagnosed patients who were not on therapy had significantly lower mean values of PCV compared to controls (p<0.05). There were no statistically significant differences in the mean values of total white blood cell counts and platelets count of newly diagnosed patients that are not on therapy and controls (p>0.05). The mean PCV levels were significant lower as compared to controls (p<0.05) Patients that were on chemotherapy had significantly lower values of PCV, total white cell counts and platelets compared to patients who were not yet on any therapy (p <0.05). There were no statistically significant differences in the PCV, total white blood cell counts and platelets based on the different stages of breast cancer (p >0.05). Findings of this study have shown that breast cancer patients had a lower PCV and TWBC count compared to controls. Chemotherapy further exerts adverse effects on patients as seen with the significantly decreased values of haematological parameters on patients on therapy. Findings of this study also shows that breast cancer patients have low PCV and WBC count compared to controls. Haematological investigation should be taken as an essential tool in the investigation and management of breast cancer. Active breast cancer awareness campaign should be carried out on the need for early diagnosis. More research should be carried out to investigate the pattern of other haematological parameters in breast cancer disease.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%