Comparative study of human eutopic and ectopic endometrial mesenchymal stem cells and the development of an in vivo endometriotic invasion model

Kao, An-Pei; Wang, Kai-Hung; Chang, Chia‐Cheng; Lee, Jau-Nan; Long, Cheng‐Yu; Chen, Hung-Sheng; Tsai, Cheng-Fang; Hsieh, Tsung‐Hua; Tsai, Eing‐Mei

doi:10.1016/j.fertnstert.2010.09.064

Cited by 132 publications

(121 citation statements)

References 45 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…As expected, our results showed that DJ-1 protein was significantly highly expressed in ectopic endometria of endometriosis compared with the eutopic or normal endometria, indicating that the migration and invasion potential of ectopic endometrial cells are more strong [10,19]. This may be attributed to the mesenchymal origin because Kao et al demonstrated that the ectopic endometrial mesenchymal stem cells formed more new blood vessels and invaded surrounding tissues [20]. Besides, our result showed that the expression of both DJ-1 and p-mTOR in the epithelial cell was higher than that in stromal in the ectopic endometrum, suggesting the distribution and location of DJ-1 and p-mTOR would be useful in evaluating the differences between ectopic and eutopic endometrum.…”

Section: Discussionsupporting

confidence: 64%

Expression of DJ-1 and mTOR in Eutopic and Ectopic Endometria of Patients with Endometriosis and Adenomyosis

Guo

Gao

et al. 2015

Gynecol Obstet Invest

View full text Add to dashboard Cite

Objective: Endometrial cells may aberrantly express molecules involved in invasion and migration, leading to endometriosis. The aim of this study was to investigate the expression of DJ-1 and phosphorylated mammalian target of rapamycin (p-mTOR) in ectopic and eutopic endometria of endometriosis and adenomyosis. Methods: Endometrial specimens were obtained from healthy non-menopausal women (n = 17) or patients with ovarian endometriotic cysts (n = 48) or adenomyosis (n = 30) during January 2011 to June 2012. The expressions of DJ-1 and p-mTOR were evaluated by immunohistochemistry and western blotting methods. Results: The expressions of DJ-1 and p-mTOR were significantly higher in the ectopic endometria than those in the eutopic endometria of endometriosis and adenomyosis patients or normal endometria (FDR < 0.05). DJ-1 expression was positively correlated with the p-mTOR expression no matter at endometriosis (r = 0.736, FDR < 0.001) or adenomyosis (r = 0.809, FDR < 0.001). Conclusion: DJ-1 protein may be involved in endometrial cells proliferation, migration and angiogenesis by modulating the PI3K/Akt/p-mTOR signaling pathway, which provides an underlying theoretical target for endometriosis and adenomyosis.

show abstract

Section: Discussionsupporting

confidence: 64%

Expression of DJ-1 and mTOR in Eutopic and Ectopic Endometria of Patients with Endometriosis and Adenomyosis

Guo

Gao

et al. 2015

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…Notably, MSCs isolated from ectopic lesions show greater invasiveness and migration ability as well as the capacity to stimulate neoangiogenesis compared to those in eutopic endometrium. 26 These cellular differences may relate to the distinct niche environment in ectopic sites 36 or, alternatively, reflect the early-life origins of ectopic eMSCs. 7 Until recently, the presence of an endometrioma in adolescents was considered the exception.…”

Section: Adolescent Endometriosis: Hemorrhagic Lesions and Endometriomentioning

confidence: 99%

Origins and Progression of Adolescent Endometriosis

et al. 2016

View full text Add to dashboard Cite

Accumulating evidence indicates that adolescent endometriosis is common and often severe. Here we explore the possibility that seeding of naive endometrial progenitor cells into the pelvic cavity early in life, that is, at the time of neonatal uterine bleeding or soon after the menarche, results in more florid and progressive disease, characterized by highly angiogenic implants, recurrent ectopic bleeding, and endometrioma formation. We discuss the potential intergenerational risk factors associated with earlyonset endometriosis and explore the molecular drivers of disease progression. Taken together, the available data suggest that an increased focus on early-life events may help to identify young women at risk of severe, progressive endometriosis.

show abstract

“…А. Kao и соавт. [47] успешно выделили и охарактеризовали человеческие мезен-химные стволовые клетки как из эутопического эн-дометрия, так и из очагов эндометриоза. Выделен-ные ММСК демонстрировали отличительные свой-ства стволовых клеток in vitro, такие как клоноген-ность, пролиферативная активность и способность дифференцироваться в клетки мезодермального происхождения.…”

Section: доказательства функциональной роли стволовых клеток при эндоunclassified

The role of stem cells in the pathogenesis of endometriosis (а review)

Фархат¹,

Savilova²,

Makiyan³

et al. 2016

Probl. reprod.

View full text Add to dashboard Cite

Эндометриоз -хроническое заболевание, кото-рое представляет собой доброкачественное разраста-ние вне полости матки ткани, по морфологическим и функциональным свойствам подобной эндоме-трию [1]. Эктопические очаги эндометрия чаще все-го локализуются на яичниках, брюшине малого таза, в позадиматочном пространстве, крестцово-маточ-ных связках, на задних листках широких связок мат-ки и в области ректовагинальной перегородки. Реже очаги эндометриоза распространяются на серозный покров кишечника, мочевой пузырь, шейку матки, влагалище, лимфатические узлы, кожу, плевру и го-ловной мозг [2,3].Эндометриоз у женщин, страдающих бесплоди-ем и тазовыми болями, наблюдается более чем в 50% случаев. Общее количество больных эндометриозом в популяции (в 2013 г.) составило около 176 млн [1,4]. Эндометриоз -доброкачественное заболевание, поражающее 6-10% женщин репродуктивного возраста, а также основная причина хронических тазовых болей и бесплодия. в циклическом восстановлении ткани эндометрия определена роль популяции стволовых клеток, которые являются источником его физиологической регенерации. Представляет интерес патогенетическая роль стволовых клеток в формировании кровеносных сосудов de novo и дальнейшей инвазии очагов эктопического эндометрия. изучение патогенеза эндометриоза в аспекте исследования его стволовых (прогениторных) клеток представляет новые возможности в разработке более эффективных методов терапии.Ключевые слова : ангиогенез, костный мозг, эндометриоз, эндометрий, эндотелиальные клетки-предшественники, мезенхимные стволовые клетки, стромальные клетки, васкулогенез

show abstract

Comparative study of human eutopic and ectopic endometrial mesenchymal stem cells and the development of an in vivo endometriotic invasion model

Cited by 132 publications

References 45 publications

Expression of DJ-1 and mTOR in Eutopic and Ectopic Endometria of Patients with Endometriosis and Adenomyosis

Expression of DJ-1 and mTOR in Eutopic and Ectopic Endometria of Patients with Endometriosis and Adenomyosis

Origins and Progression of Adolescent Endometriosis

The role of stem cells in the pathogenesis of endometriosis (а review)

Contact Info

Product

Resources

About