Comparative study of intraperitoneal adhesions related to light-weight polypropylene mesh and type I polymerized and purified bovine collagen coated light-weight polypropylene mesh in rabbits

Abstract

Comparative study of intraperitoneal adhesions related to light-weight polypropylene mesh and type I polymerized and purified bovine collagen coated light-weight polypropylene mesh in rabbits 1 2-Experimental SurgeryActa Cir Bras. 2017;32(11):903-912 AbstractPurpose: To compare the effectiveness of light-weight polypropylene mesh coated with polymerized and purified bovine type I collagen (Surgidry HNB) in the treatment of abdominal wall defect and the degree of adhesion formation. Methods: Two types of polypropylene mesh were implanted after creation of defect measuring 6.0cm X 5.5cm in the anterior abdominal wall of 32 male New Zealand breed rabbits, divided in two groups (n = 32): (1) light-weigh macroporous polypropylene, (2) type I polymerized and purified bovine collagen coated light-weigh macroporous polypropylene. These animals were further accessed for adhesions, histological evaluation of inflammation and wall's thickness. Results:The percentage of the area adhered in group 1 (62.31 ± 16.6) was higher compared to group 2 (22.19 ± 14.57) (p <0.05). There was an association between the percentage of the covered area by adhesions and the type of adhesion, toughness and the scores obtained by the adhesion score by correlation analysis (p <0.05). There was no difference between the groups in any variables in relation to the degree of inflammation. Conclusion:The purified type I bovine collagen coated light-weigh polypropylene mesh showed to be effective in the repair of abdominal wall defects and reducing adhesion formation. 903Comparative study of intraperitoneal adhesions related to light-weight polypropylene mesh and type I polymerized and purified bovine collagen coated light-weight polypropylene mesh in rabbits Garcia DPC et al. Acta Cir Bras. 2017;32(11):903-912

Comparative study of peritoneal adhesions after intraperitoneal implantation in rats of meshes of polypropylene versus polypropylene/polyglecaprone versus polyester/porcine collagen

“…Similar results were found by Garcia et al . 19 in an experimental study with rabbits with polypropylene mesh versus polypropylene with bovine collagen, where animals with only a polypropylene mesh presented a greater surface area of adhesion compromise with intra-abdominal viscera compared to the double-sided mesh. However, the result of the present study differs from the study by Biondo-Simões et al .…”

“…Garcia et al . 19 concluded that the polypropylene mesh, although effective in treating abdominal wall defects, causes an intense inflammatory and foreign body reaction. The appearance of dense and firm adhesions with the intra-abdominal viscera is attributed to this bioincorporation process of the intraperitoneally implanted mesh.…”

Biomechanical and adhesion comparison of linea alba prophylactic reinforcement with coated and uncoated three-dimensional T-shaped mesh in rabbits

“…However, this practice has failed to obtain widespread adoptance, probably due to a lack of technique standardization and concerns for mesh-related complications, including chronic pain, prosthesis infection, seroma formation, in addition of increased cost and operative time. Moreover, a survey study by Bloemen et al 21 revealed that only 35% of Dutch surgeons close the abdominal fascia using the recommended 4:1 length suture and 68% didn't change their closure technique since their training, showing that surgeons have some aversion to change their practices.…”

Adhesive Process in Abdominal Cavity After Abdominal Wall Reconstruction With Components Separation Use (Experimental Study)

“…Хорошо известны трудности, возникающие в ряде случаев при восстановлении глубоких слоев брюшной стенки (задние листки влагалищ прямых мышц живота, брюшина) в ходе операции TAR, что может приводить к прямому контакту эндопротеза с органами брюшной полости на некоторых участках [11]. Моделирование таких операций на лабораторных животных является существенным дополнением для клинического опыта [12]. Вариант использования двух сеток (полипропиленовой и резорбируемой полиглактиновой) исследован в эксперименте с обнадеживающими результатами [11].…”