Comparative Study of Liver Function and Rh Blood Group between both Physiological and Pathological Neonatal Jaundice

Abstract

Abstract
 Backgrounds: Jaundice occurs in most newborn due to increased bilirubin concentration. Jaundice is observed during the first week after birth in approximately 60% of term neonates. A high level of bilirubin is neurotoxic and may cause neonatal kernicterus, auditory neuropathy or death.
 Objectives: to compare the Rh group compatibility, serum bilirubin (total and direct), serum albumin and several liver enzymes between physiological and pathological neonatal jaundice
 Materials and Methods: A cross sectional study for one hundred neonates with jaundice divided into group 1: 50 newborns with physiological jaundice, Group 2: 50 newborns with pathological jaundice. Blood samples taken from each patient use to determination of Rh Group and blood group, serum bilirubin (total and direct, liver enzymes and albumin concentration. Results: in the present study Rh Compatibility show a significant relationship between newborns with physiological and pathological jaundice (p<0.05). Serum bilirubin (total and direct), serum albumin concentration and several liver enzymes were significantly higher when compare newborns with pathological jaundice with newborns of physiological jaundice (p<0.05).
 Conclusion: these finding demonstrate that newborns with pathological jaundice have higher concentrations of these parameters as compared with physiological jaundice .

The Impact of G6PD Deficiency on Liver Function in Children Under 15

“…These results contradicted those found by Kamal and Hassan (2021) who revealed that gender influences the occurrence of jaundice in newborns, with male infants having a lower risk than female infants [26]. Various degrees of liver disease exist because ALT is restricted to the liver, unlike AST, which is abundant in other organs, such as kidneys, brain, and heart.…”