Comparative study of microfibrillar collagen hemostat (Colgel) and oxidized cellulose (Surgicel) in high transfusion-risk cardiac surgery

Şırlak, Mustafa; Eryilmaz, Sadık; Yazıcıoğlu, Levent; Kızıltepe, Uğursay; Eyileten, Zeynep; Durdu, Serkan; Taşöz, Refik; Eren, Neyyir Tuncay; Aral, Atilla; Kaya, Bülent; Akalin, Hakkı

doi:10.1016/s0022-5223(03)00042-4

Cited by 54 publications

(34 citation statements)

References 14 publications

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“…For high transfusion risk cardiac surgery patients, including repeat cardiac operations (such as aorta coronary bypass operations or valvular operations), ascending aortic aneurysm repair necessitating deep hypothermic circulatory arrest and ascending aortic grafting without deep hypothermic circulatory arrest Surgicel has been compared with microfibrillar collagen hemostat (Colgel [Laboratorie Interphar, Aubervilliers, France]) in terms of the ability to reduce postoperative bleeding and was found to be superior in terms of reducing postoperative drainage (Table 1) [7]. Microfibrillar collagen is not as good at reducing infection risk as Surgicel [5] and is reported to cause end-organ damage if shed blood containing it is returned to the circulation by either pump suction or cell salvage devices, as it may readily pass through the filters of these devices [8].…”

Section: Microfibrillar Collagen Was Initially Described In 1969mentioning

confidence: 99%

A Review of Topical Hemostatic Agents for Use in Cardiac Surgery

Barnard

Millner

2009

The Annals of Thoracic Surgery

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Section: Microfibrillar Collagen Was Initially Described In 1969mentioning

confidence: 99%

A Review of Topical Hemostatic Agents for Use in Cardiac Surgery

Barnard

Millner

2009

The Annals of Thoracic Surgery

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“…Hemostatic materials can be formed by combining one or two coagulation cascades or hemostatic proteins including thrombin [97], collagen [98], chitosan [99, 100], and fibrin [4, 101] as well as non-protein materials such as oxidized cellulose [98, 102] and PEG [102]. These hemostats have been used in various forms for surgical applications including matrix [98, 103], patch [104, 105] or liquid [97, 101].…”

Section: Nanoparticle Incorporated Surgical Materialsmentioning

confidence: 99%

Surgical materials: Current challenges and nano-enabled solutions

et al. 2014

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Surgical adhesive biomaterials have emerged as substitutes to sutures and staples in many clinical applications. Nano-enabled materials containing nanoparticles or having a distinct nanotopography have been utilized for generation of a new class of surgical materials with enhanced functionality. In this review, the state of the art in the development of conventional surgical adhesive biomaterials is critically reviewed and their shortcomings are outlined. Recent advancements in generation of nano-enabled surgical materials with their potential future applications are discussed. This review will open new avenues for the innovative development of the next generation of tissue adhesives, hemostats, and sealants with enhanced functionality for various surgical applications.

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“…Karagiannis and colleagues (2008) reported good outcomes with use of type I collagen in 5 obstetric and 3 gynecologic cases [58]. Use of microfibrillar collagen has shown to reduce blood loss more effectively relative to oxidized regenerated cellulose [59]. One industry-sponsored porcine study found equal efficacy of collagen alone (Ultrafoam, Bard Davol) and gelatin matrix with thrombin (Gelfoam hemostasis kit, Baxter, Deerfield, IL) [60].…”

Section: Comparison To Other Topical Hemostatic Agentsmentioning

confidence: 99%

Use of Monsel solution to treat obstetrical hemorrhage: a review and comparison to other topical hemostatic agents

Miller

Roque

Santin

2015

American Journal of Obstetrics and Gynecology

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Peripartum hemorrhage accounts for 8% of maternal deaths in the United States, and nearly 27% worldwide. A growing need exists for tactics to spare morbidity given a rise of abnormal placentation that contributes to excessive blood loss at the time of delivery. Approaches such as compression sutures, balloon tamponade, and pelvic artery embolization are not without side effects and potential implications for future fertility. The use of topical hemostatic agents has become widespread in gynecologic and obstetric surgery despite a paucity of distinct studies in the field, and may allow providers to increasingly avoid cesarean hysterectomy. A variety of topical hemostatic agents exist along a wide cost continuum, each characterized by specific efficacy, advantages, drawbacks, and often gaps in long-term data to support safety and impact on future fertility. Herein, we comprehensively review these agents and illustrate a non-traditional use of Monsel’s solution applied directly to the placental bed in a case of focal placenta accreta. This ultimately contributed to successful uterine preservation with no known adverse sequelae. Monsel’s solution may have a role in establishing hemostasis in the setting of abnormal placentation, and may be a particularly attractive alternative in resource-poor nations.

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Comparative study of microfibrillar collagen hemostat (Colgel) and oxidized cellulose (Surgicel) in high transfusion-risk cardiac surgery

Abstract: In conclusion, the easy application, low cost, and significant blood-loss reduction effect of microfibrillar collagen powder renders this agent attractive for cardiac operations associated with high risk of bleeding.

Cited by 54 publications

References 14 publications

A Review of Topical Hemostatic Agents for Use in Cardiac Surgery

A Review of Topical Hemostatic Agents for Use in Cardiac Surgery

Surgical materials: Current challenges and nano-enabled solutions

Use of Monsel solution to treat obstetrical hemorrhage: a review and comparison to other topical hemostatic agents

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