Comparative study of nitroglycerin dermal patch versus nifedipine in the management of preterm labour

Kaur, Manjeet; Goel, Bharti; Singh, Jasveer

doi:10.18203/2320-1770.ijrcog20184160

Cited by 2 publications

(3 citation statements)

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“…The most widely used tocolytic medication is nifedipine, which blocks voltage-dependent calcium channels in the plasma membrane, increases calcium efflux from cells, and decreases intracellular free calcium, inhibiting calcium-dependent MLCK (myosin light chain kinase) phosphorylation and myometrial relaxation [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…A glutathione-dependent organic nitrate reductase in the liver quickly metabolizes the active chemical. Transdermal administration of the drug helps avoid it by ensuring that an adequate amount reaches plasma concentrations [ 13 ]. By relaxing the uterine smooth muscles, it defers delivery while also enhancing blood flow to the uterus and placenta.…”

Section: Introductionmentioning

confidence: 99%

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A Comparative Study of the Effectiveness of Transdermal Nitroglycerine Patches and Oral Nifedipine in Prolongation of Pregnancy in Women With Preterm Labour

Goyal¹,

Agrawal²,

Dewani³

et al. 2023

Cureus

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Backgrounds A significant contributor to newborn morbidity and mortality is preterm birth. Several techniques have been employed to identify patients at risk of premature labour. However, these predictors are not always effective because of their multifactorial aetiology. Preterm labour can be suppressed largely through tocolysis. This study compared the effectiveness and safety of transdermal nitroglycerine and oral nifedipine in preventing premature labour. Methods This study was done at Acharya Vinoba Bhave Rural Hospital, Sawangi, Wardha, Maharashtra, from December 2020 to November 2022, on 130 women presenting with preterm labour pains between 28 and 37 weeks of gestational age. All the women selected were randomized into two equal groups by using the envelope method. Sixty-five women were given a nitroglycerine patch (Group A), and the rest (65 women) were given an oral nifedipine tablet (group B). The variables studied were mean days of prolongation of pregnancy, treatment outcome, steroid coverage, along with feto-maternal outcomes among both groups. Results The percentage of women whose pregnancy was prolonged for at least 48 hours in the nitroglycerine group was 75.3%, and in the nifedipine group it was 93.8%. Failure to achieve tocolysis, defined as delivery within 48 hours, was seen significantly more in the nitroglycerine group (24.6%) than in the nifedipine group (6.1%). The overall foetal outcomes were comparable in both groups. Conclusion Oral nifedipine was found to be superior to transdermal nifedipine patches in terms of efficacy and safety in the management of preterm labour, with a better side effect profile.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Comparative Study of the Effectiveness of Transdermal Nitroglycerine Patches and Oral Nifedipine in Prolongation of Pregnancy in Women With Preterm Labour

Goyal¹,

Agrawal²,

Dewani³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…3 Nifedipine which works by blocking the voltage dependent calcium channels in the plasma membrane, increasing calcium efflux from cell and decreasing intracellular free calcium, thus causing inhibition of calcium dependent MLCK (myosin light chain kinase) phosphorylation and myometrial relaxation, is the most commonly used tocolytic drug. 4 Another emerging drug which is used as a tocolytic is nitroglycerin, worldwide known as glyceryl trinitrate (GTN). It is a low molecular weight nitrate which is highly volatile in nature and also known as nitro vasodilator.…”

mentioning

confidence: 99%

Comparative study of efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1-year study at navodaya medical college hospital and research centre Raichur

Rita

Haripriya

2021

Int J Reprod Contracept Obstet Gynecol

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Background: Tocolytic agents are used to reduce preterm deliveries. Very few studies documenting the comparison of tocolytic agents viz. nifedipine, nitroglycerin dermal patches and isoxsuprine. Other drugs are not used due to their adverse effects. Objective was to study and compare the safety efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1 year study.Methods: This was a prospective case control study was conducted for a period of 1 year. Total 90 cases selected to study were randomly distribute in to three treatment groups viz. A, B, and C nifedipine, nitroglycerin and isoxsuprine respectively. Subjects in all three groups were evaluated for maternal pulse rate, palpitation uterine contractions and fetal heart rate in order to assess efficacy of each drug under investigation.Results: There was no statistically significant difference in age of woman’s in three different groups. Among (100%) subjects, majority of the cases i.e. (27.8%) primi gravida followed by multi (72.2%). Side effects of nifedipine was less when compared to nitroglycerine dermal patch and isoxsuprine i/v/o of headache (8.9%), nausea (1.1%), vomiting (1.1%), tachycardia (3.3%), palpitation (3.3%), hypotension (1.1%). side effects were statistically significant different between the treatment groups. There was no statistically significant difference with respect to APGAR score at 1 minute and 5 minutes.Conclusions: Oral nifedipine was found to be superior and efficacious as tocolytic agent as compared to transdermal nitroglycerin and intravenous isoxsuprine.

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Comparative study of nitroglycerin dermal patch versus nifedipine in the management of preterm labour

Cited by 2 publications

References 15 publications

A Comparative Study of the Effectiveness of Transdermal Nitroglycerine Patches and Oral Nifedipine in Prolongation of Pregnancy in Women With Preterm Labour

A Comparative Study of the Effectiveness of Transdermal Nitroglycerine Patches and Oral Nifedipine in Prolongation of Pregnancy in Women With Preterm Labour

Comparative study of efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1-year study at navodaya medical college hospital and research centre Raichur

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