Comparative Study of Oncologic Outcome of Laparoscopic Nephroureterectomy and Standard Nephroureterectomy for Upper Urinary Tract Transitional Cell Carcinoma

Abstract

In the surgical management of upper tract transitional cell carcinoma, LNU does not negatively affect long-term oncologic control and can be considered an alternative modality. Tumor stage and grade are, however, important prognostic factors in the incidence of metastases and cancer-specific mortality.

Long-term results of retroperitoneoscopic nephroureterectomy for upper urinary tract transitional cell carcinoma in China

“…Similar to two other previous retrospective studies on upper urinary tract TCC treatment and recurrence, 23,24 we find that the T stage, grade, lymph node metastasis and bladder tumour history are risk factors for tumour recurrence, and the operation mode and the bladder cuff incision mode has no correlation with the recurrence. In our cohort, the mean follow-up time was 42.4 months, and the three-year cancer specific survival rates was 80.7% in RNU group, and 80.3% in the ONU group, no statistically differences was observed.…”

Canadian guidelines for postoperative surveillance of upper urinary tract urothelial carcinoma

“…31 Other prognostic variables following nephroureterectomy include lymphovascular invasion, concomitant carcinoma in situ (CIS), positive surgical margins, ureteral tumour location (as opposed to renal pelvis), previous or concomitant bladder tumours, tumour multifocality, and lack of postoperative intravesical mitomycin C instillation. 4,6,7,[10][11][12][14][15][16][17][18][19][21][22][23][24]26,[28][29][30][31][32][33][34][35][36][65][66][67][68][69] The rates of recurrence stratified by these variables are seldom reported.…”

“…Several studies report very low incidences of port-site recurrences, usually associated with inadvertent entry into the collecting system. 10,18,20,23,25 Among 72 patients with pT3 tumours and a median follow-up of 26.5 months, recurrences of the retroperitoneum/pelvis and contralateral upper tract were observed in 7% and 3%, respectively. 27 Distant metastases occurred following nephroureterectomy in 16.4% of patients (8%-28%; 46.8 months).…”

Laparoscopic Nephroureterectomy: Oncologic Outcomes

“…No significant difference was detected in recurrence-free survival and cancer-specific survival. Manabe et al (2007) evaluated 58 patients after LNU (mean follow-up 13.6 months) and 166 after ONU (mean follow-up 28 months). Bladder recurrence was reported in 33% of patients after LNU and in 38% after ONU [22].…”