Comparative Study of Potential Endothelioprotectors and Impaza in Modeled Nitric Oxide Defi ciency

Abstract

Experimental NO deficiency induced by L-NAME injection led to the development of arterial hypertension, endothelial dysfunction, and cardiomyocyte hypertrophy and reduced blood content of nitrates and nitrites. Impaza, NO donors, activators of NO-synthase, antioxidants, and antihypertensive preparations produced endothelium-protective effect of different degree.

Correction of morphofunctional disturbances arising when modelling Preeclampsia with resveratrol and nicorandil

“…The degree of endothelial dysfunction in the experimental animals was assessed by the ratio of indices of endothelium-dependent vasodilation and endothelium-independent vasodilation with subsequent calculation of the coefficient of endothelial dysfunction (CED) (Korokin et al 2011, Pokrovsky et al 2006.…”

“…Earlier in our laboratory, the endoteleoprotective properties of resveratrol and nicorandil (Danilenko 2013, Kochkarov 2009, Kochkarov et al 2006, Kochkarov 2008 were studied which could activate K+ ATP channels , Novaković et al 2015; therefore we considered them to be the most promising for our studies.…”

Method of Correction of Endothelial Dysfunction With Combination of Ademetionine and Taurine

“…Main part: In connection with the foregoing, the purpose of this study was the investigationthe endotheliopathy properties of a combination of ademetionine in the dose of 150 mg/kg/day and taurine at a dose of 260 mg/kg/day as one of the possible effective combinations with dysfunction of endothelium, L-NAME-induced [16,17,18 …”

“…To assess the degree of endothelial dysfunction in experimental animals and its correction by researched drugs we have performed the calculation of the coefficient of endothelial dysfunction (CED) [16,17,18,19].…”

ENDOTHELIO-AND CARDIOPROTECTIVE EFFECTS OF HMG-Co-A REDUCTASE IN ENDOTOKSIN-INDUCING ENDOTELIAL DYSFUNCTION

“…Несмотря на многочисленные исследования сердечно-сосудистые заболевания остаются среди главных причин смертности и инвалидизации. При этом, акцент в исследованиях направленных на изучение патогенеза и разработки мер профилактики, очевидно, смещается в сторону эндотелиальной дисфункции [15,4,6] и роли цитокинов [14,3,7] в формировании атеросклеротических повреждений сосудов.…”