Comparative study of proton pump inhibitors on dexamethasone plus pylorus ligation induced ulcer model in rats

Thippeswamy, A. H. M.; Sajjan, M; Palkar, MB; Koti, BC; Viswanathaswamy, A.H.M

doi:10.4103/0250-474x.70486

Cited by 9 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, the pH of the rat stomach in the WIR group was significantly reduced during the progression of stress ulcers and was dose-dependently reversed by the pretreatments with esomeprazole due to its vigorous acid suppression ability (Figure 3A). Our study also showed that prophylactic application of esomeprazole decreased the secretion of pepsin (Figure 3C) in agreement with previous studies 43. We speculate that the decrease of pepsin levels may be partially associated with the inhibition of acid caused by esomeprazole.…”

Section: Discussionsupporting

confidence: 92%

<p>Esomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways</p>

Xie¹,

Huang²,

Chen³

et al. 2019

DDDT

View full text Add to dashboard Cite

BackgroundStress ulcer is a severe complication in critically ill patients and causes a high mortality. The proton pump inhibitor esomeprazole is widely applied in the treatment of stress ulcers because of its powerful acid suppression ability. However, the mechanism of stress ulcer and the precise gastroprotective effect of esomeprazole in stress ulcer remain unclear.PurposeIn the present study, the rats with water-immersed and restraint (WIR)-induced stress ulcer were used to further elucidate the anti-ulcerogenic capacity of esomeprazole in stress ulcer in addition to its anti-acid secreting ability.Methods and resultsThe rats were randomly divided into 5 groups: control group (NS), water-immersed and restraint group (WIR), high-dose application of esomeprazole plus stress ulcer-induced group (HE+WIR), low-dose application of esomeprazole plus stress ulcer-induced group (LE+WIR), and high-dose application of esomeprazole without stress ulcer-induced group (HE). Our study showed that the pretreatment of esomeprazole alleviated gastric tissue damage in both macroscopic and histopathological manifestations. Pretreatment of esomeprazole elevated the decline in PEG2 level affected by WIR; and it inhibited the secretion of gastric acid, gastrin and pepsin. Moreover, esomeprazole exerted its antioxidant effects by reducing malondialdehyde levels, enhancing the expressions of antioxidant factors like glutathione and superoxide dismutase (SOD) and reducing the compensatory transcriptional elevation of SOD1 gene. Esomeprazole also reduced the levels of MPO (myeloperoxidase), tumor necrosis factor (TNF)-α and interleukin (IL)-1β according to its anti-inflammatory effects. We further explored the possible mechanism of esomeprazole pretreatment on stress ulcer and demonstrated that esomeprazole attenuated the high phosphorylation levels of nuclear factor kappa B (NF-κB) p65 and p38 MAPK, and decreased the NF-κB p65 nuclear translocation induced by WIR related stress ulcer.ConclusionOur study provides some evidence that the esomeprazole pretreatment exerts gastroprotective effects in WIR-induced stress ulcer through not only its antisecretory effect but also its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways.

show abstract

Section: Discussionsupporting

confidence: 92%

<p>Esomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways</p>

Xie¹,

Huang²,

Chen³

et al. 2019

DDDT

View full text Add to dashboard Cite

show abstract

“…In study [ 27 ], induction to ulcer using aspirin is combined with ethanol. Omeprazole [ 27 , 30 ], sucralfate [ 26 , 31 , 32 ], mannitol [ 28 , 33 ], and cimetidine [ 29 , 34 , 35 ] have been used in these studies as referral drugs as well as some comparative substances to the efficacy of honey or comparative substances used in the experiments. Different doses used depend on the duration of the experiment and the weight of the rats.…”

Section: Resultsmentioning

confidence: 99%

Antiulcer Effect of Honey in Nonsteroidal Anti‐Inflammatory Drugs Induced Gastric Ulcer Model in Rats: A Systematic Review

Fazalda

Adam

Azlina

2018

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background Peptic ulcer is a basic term for ulcers on the lower oesophagus, stomach, or jejunum. The specific term for ulcer in the stomach is gastric ulcer. The extensive use of honey around the globe helps researchers to study the usefulness of honey. Many studies had already been conducted and proved the effectiveness of honey in treating gastric ulcer. Methods A systematic review of the literature was conducted to identify relevant studies on honey used as an alternative treatment of gastric ulcer cause by NSAIDs. A comprehensive search was conducted in Medline, SCOPUS, and Ebscohost. The main criteria used were articles published in English and using NSAIDs-induced gastric ulcer in rat's model and those reporting the effectiveness of honey. Results Articles published between 2001 and 2014 were identified to be relevant in studies related to the inclusion criteria. The literature search found 30 potential and closely related articles in this review, but only 5 articles were taken which meet the criteria needed to be fulfilled. Conclusions All studies in this review reported the efficacy of honey for gastric ulcer based on its antioxidant and cytoprotective activities. Most of the studies conducted used different types of honey at various doses on rats. Future studies should be conducted to identify the appropriate dose for humans to achieve similar gastroprotective effects.

show abstract

“…Ulcer induced group II animals showed increase in protein content of the gastric juice indicating gastric mucosal damage due to leakage of plasma proteins [32–34]. Both extracts showed decrease in protein levels, which indicates strengthening of the gastric mucosa, thereby restricting the entrance of the plasma proteins into gastric juice.…”

Section: Discussionmentioning

confidence: 99%

Antiulcer Activity of Indigenous PlantOperculina turpethumLinn.

Ignatius

Narayanan

Subramanian

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

In the Indian traditional system of medicine Operculina turpethum is commonly used to treat various ailments including peptic ulcer, inflammation, and pain. Ulcer preventive and ulcer protective activities of HAOP and MOP stem bark extracts of Operculina turpethum (100 mg/kg, b.w., orally) were evaluated employing aspirin + pylorus ligation (APL) model in experimental rats. The results suggested that both extracts (HAOP and MOP) possess enhanced ulcer preventive and protective activities when compared with the standard drug ranitidine. HAOP showed more pronounced effect when compared to MOP. Further the result of the histopathological and biochemical studies also confirms potent ulcer preventive and protective nature of a extracts in a similar manner.

show abstract

Comparative study of proton pump inhibitors on dexamethasone plus pylorus ligation induced ulcer model in rats

Cited by 9 publications

References 18 publications

<p>Esomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways</p>

<p>Esomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways</p>

Antiulcer Effect of Honey in Nonsteroidal Anti‐Inflammatory Drugs Induced Gastric Ulcer Model in Rats: A Systematic Review

Antiulcer Activity of Indigenous PlantOperculina turpethumLinn.

Contact Info

Product

Resources

About