Comparative study of the association of itraconazole with colloidal drug carriers

Chasteigner, Stéphanie de; Fessi, Hatem; Devissaguet, Jean‐Philippe; Puisieux, F.

doi:10.1002/(sici)1098-2299(199606)38:2<125::aid-ddr7>3.0.co;2-l

Cited by 29 publications

(14 citation statements)

References 42 publications

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“…The highest K 1:1 value exhibited by SBE-β-CD could be ascribed to the presence of the fourcarbon butyl chain coupled with repulsion of the end group negative charges which allows for an "extension" of the hydrophobic region of the CD cavity and thus increase its affinity towards nimodipine [27]. Which is in complete agreement with the findings of De Chasteigner (1996), suggesting that the longer the hydrophobic chain linked to the β-CD, the higher the association of drug within the complex [28].…”

Section: Phase Solubility Studiessupporting

confidence: 88%

Effects of the Preparation Method on the Formation of True Nimodipine SBE-β-CD/HP-β-CD Inclusion Complexes and Their Dissolution Rates Enhancement

et al. 2014

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Abstract. The aims of this study were to enhance the solubility and dissolution rate of nimodipine (ND) by preparing the inclusion complexes of ND with sulfobutylether-b-cyclodextrin (SBE-β-CD) and 2-hydroxypropyl-b-cyclodextrin (HP-β-CD) and to study the effect of the preparation method on the in vitro dissolution profile in different media (0.1 N HCl pH 1.2, phosphate buffer pH 7.4, and distilled water). Thus, the inclusion complexes were prepared by kneading, coprecipitation, and freeze-drying methods. Phase solubility studies were conducted to characterize the complexes in the liquid state. The inclusion complexes in the solid state were investigated with differential scanning calorimetry (DSC), Xray diffractometry (X-RD), and Fourier transform infrared spectroscopy (FT-IR). Stable complexes of ND/SBE-β-CD and ND/HP-β-CD were formed in distilled water in a 1:1 stoichiometric inclusion complex as indicated by an A L -type diagram. The apparent stability constants (Ks) were 1334.4 and 464.1 M −1 for ND/SBE-β-CD and ND/HP-β-CD, respectively. The water-solubility of ND was significantly increased in an average of 22-and 8-fold for SBE-β-CD and HP-β-CD, respectively. DSC results showed the formation of true inclusion complexes between the drug and both SBE-β-CD and HP-β-CD prepared by the kneading method. In contrast, crystalline drug was detectable in all other products. The dissolution studies showed that all the products exhibited higher dissolution rate than those of the physical mixtures and ND alone, in all mediums. However, the kneading complexes displayed the maximum dissolution rate in comparison with drug and other complexes, confirming the influence of the preparation method on the physicochemical properties of the products.

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Section: Phase Solubility Studiessupporting

confidence: 88%

Effects of the Preparation Method on the Formation of True Nimodipine SBE-β-CD/HP-β-CD Inclusion Complexes and Their Dissolution Rates Enhancement

et al. 2014

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“…The lower value of VD in the case of liposomal AmB-SBEBCD may be due to AmB dissociation, where complexed AmB has a very low elimination phase, which is in complete agreement with the findings of de-Chasteign (1996), suggesting that the longer hydrophobic chain linked to the β-CD the higher association of drug within vesicles (26). However it is also shown that the binding potential of the sulfobutyl ether β-CD derivatives is not only dependent on both sulfobutyl chain length and degree of substitution, but also on the substrate (phospholipid) properties (27).…”

supporting

confidence: 90%

PHARMACOKINETIC STUDIES OF IN-SITU LIPOSOMAL PREPARATION CONTAINING AMPHOTERICIN B COMPLEXED WITH DIFFERENT CHEMICALLY MODIFIED Β-Cyclodextrins

Chakraborty

Naik²

2001

Journal of Liposome Research

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The purpose of this study was to evaluate the influence of chemically modified beta-cyclodextrin (beta-CD) which could affect the in-vivo stabilization of liposomal preparation derived from proliposome entrapping inclusion complex of amphotericin B (AmB) with beta-CD. A series of liposomal AmB formulations with varying beta-CD i.e. Hydroxypropyl beta-CD (HPBCD) & Sulfo butyl ether beta-CD (SBEBCD) and lipid dose having similar AmB content (0.5 mg/kg) were compared with conventional liposomal amphotericin B (L-AmB) or free AmB in rats and their pharmacokinetic data were analyzed considering the varying volume of distribution with respect to the varying lipid concentration (65mg to 110mg) in blood. These results indicate that L-AmB entrapped inclusion complexes safely achieved higher Cmax (P < 0.05) & AUC (P < 0.02) and demonstrated saturable, nonlinear elimination from plasma via reticuloendothelial organ uptake at higher lipid level (>80mg) as compared with conventional L-AmB or free AmB. Furthermore in-vivo stabilization potential for liposomal preparation via AmB/ beta-Cyclodextrin inclusion complexes appeared to be in pattern of HPBCD < SBEBCD. It is concluded that the preparation of liposome derived from proliposome entrapping inclusion complex of amphotericinB (AmB) with beta-CD could serve an alternative approach to enhance the therapeutic window of AmB in clinical medicine.

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“…For example, amphotericin B-loaded nanoparticles displayed no toxicity in tissue culture in contrast to free drug and were almost as efficaciously lethal as free drug in killing C. albicans [20]. Similar strategies have been reported using itraconazole in modified b-cyclodextran nanospheres [21]. However, the approach adopted in this work relies on a nondrug-based mechanism, whereby a layer of adsorbed nanoparticles will prevent the necessary approach path required for infectious inter- action, as defined by the DLVO theory [22].…”

Section: Discussionmentioning

confidence: 56%

Bioadhesive, non-drug-loaded nanoparticles as modulators of candidal adherence to buccal epithelial cells: a potentially novel prophylaxis for candidosis

et al. 2004

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Comparative study of the association of itraconazole with colloidal drug carriers

Cited by 29 publications

References 42 publications

Effects of the Preparation Method on the Formation of True Nimodipine SBE-β-CD/HP-β-CD Inclusion Complexes and Their Dissolution Rates Enhancement

Effects of the Preparation Method on the Formation of True Nimodipine SBE-β-CD/HP-β-CD Inclusion Complexes and Their Dissolution Rates Enhancement

PHARMACOKINETIC STUDIES OF IN-SITU LIPOSOMAL PREPARATION CONTAINING AMPHOTERICIN B COMPLEXED WITH DIFFERENT CHEMICALLY MODIFIED Β-Cyclodextrins

Bioadhesive, non-drug-loaded nanoparticles as modulators of candidal adherence to buccal epithelial cells: a potentially novel prophylaxis for candidosis

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