2010
DOI: 10.1016/j.ijdevneu.2010.04.003
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Comparative study of the effects of experimentally induced hypothyroidism and hyperthyroidism in some brain regions in albino rats

Abstract: Thyroid hormones (THs) play a crucial role in the development and physiological functioning of different body organs especially the brain. Therefore, the objective of this study was to show the histopathological effects of the different thyroid states on some brain regions (cerebrum and cerebellum) and the skeletal features of their newborns during the postnatal development from the 1st to 3rd week. The female white albino rats were allocated into 3 groups as follows: the experimental hypothyroidism group is i… Show more

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Cited by 54 publications
(42 citation statements)
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References 82 publications
(109 reference statements)
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“…Concomitantly, there is some degeneration, deformation and severe growth retardation in neurons of these regions in both groups (El-Bakry et al, 2010). Therefore, TH play an important role in brain development, neuronal migration and axonal projection to target cells.…”
Section: Thyroid Hormones and Brainmentioning
confidence: 99%
“…Concomitantly, there is some degeneration, deformation and severe growth retardation in neurons of these regions in both groups (El-Bakry et al, 2010). Therefore, TH play an important role in brain development, neuronal migration and axonal projection to target cells.…”
Section: Thyroid Hormones and Brainmentioning
confidence: 99%
“…The steady in the functions of gestational thyroid hormones (THs) displays major actions in the developing brain in particular the development and differentiation of neurons, oligodendrocytes, astrocytes and microglial cells (El-bakry et al, 2010;Ahmed, 2011Ahmed, , 2012aAhmed, ,b, 2013Ahmed, , 2014Ahmed, , 2015aAhmed, -c, 2016aAhmed, -d, 2017aAhmed, -u & 2018aAhmed et al, , 2013aAhmed et al, ,b, 2014Ahmed et al, , 2015aAhmed and Incerpi, 2013;Van Hercket al, 2013;ElGareib, 2014, Incerpi et al, 2014;Candelotti et al, 2015;De Vito et al, 2015;El-Ghareeb et al, 2016;Ahmed and El-Gareib, 2017;Moog et al, 2017).…”
Section: Commentarymentioning
confidence: 99%
“…Any reduction in the availability of THs might possibly disturb the fetal and neonatal development [1][2][3][4][5][6][7][8][9][10][24][25][26]. These imbalances resulting from the production of free radicals, lipid peroxidation (LPO), carbonylation and nitration, and reduce the enzymatic and non-enzymatic antioxidant defense system [2,5,6,[33][34][35].…”
Section: Commentarymentioning
confidence: 99%