Comparative Study of the Effects of 1% Atropine on the Anterior Segment

Abstract

Purpose. To investigate the influences of atropine on changes in anterior segment geometry, as measured by ultrasound biomicroscopy in children. Methods. A prospective observational study was performed. Anterior segment parameters were obtained by UBM before and after the instillation of 1% atropine. Univariate linear regression was performed to identify the variables contributing to the changes in the trabecular meshwork-iris angle (TIA). Results. The study included 21 boys and 37 girls with a mean age of 10.79 ± 2.53 years. Anterior chamber parameters including the central anterior chamber depth, TIA, angle opening distance at 500 μm from the scleral spur, iris thickness 750 μm and 1500 μm from the scleral spur, trabecular-ciliary angle (TCA), trabecular-ciliary process distance, sclera-iris angle (SIA), and sclera-ciliary process angle significantly increased after cycloplegia ( P < 0.05 ). In contrast, the lens vault, iris cross-sectional area, and maximum ciliary muscle thickness significantly decreased after cycloplegia. Univariate analysis identified the change in TCA and the change in SIA and the TIA before mydriasis as determinants of the change in TIA. Conclusions. Atropine causes statistically significant changes in various anterior segment parameters in children. The change in anterior chamber angle is associated with the change in TCA and the change in SIA and the TIA before mydriasis.

Evaluation of anterior chamber morphology following scleral buckling with Pentacam

“…These processes, together with retrograde ow through the trabecular meshwork in the setting of hypotony, cause the pressure in the anterior chamber to rise above that in the posterior chamber, resulting in posterior bowing of the iris [23]. Third, Zhou et al reported that use of atropine could increase the ACA measured by Pentacam, which is similar to our study [24]. Moreover, Fernández-Vigo et al [25] showed that Pentacam tends to overestimate the measurements of narrow angles and underestimate that of open angles in comparison with OCT measurements.…”

Effect of combined use of orthokeratology and atropine eye drops on correction of myopia in young children, and its influencing factors

“…Studies have demonstrated that atropine drugs used for treating myopia effectively relieve tension in ciliary muscles, resulting in complete muscle relaxation, thereby eliminating the problem of pseudomyopia due to eye fatigue [13].…”

Characteristics of ciliary muscle profile in high myopes measured by swept-source anterior segment optical coherence tomography

“…Incorporating proportional CMT measures may be required to ensure comparisons are made in similar regions of ciliary muscles. Fifth, a recent study observed alternations in CMT after administering 1% atropine [ 59 ]. However, considering the varying accommodative demands between the low and high myopic groups when fixating on the fixation target during measurements, the current study employed two drops of 1% tropicamide to minimize the potential accommodation fluctuations and mitigate their impact on the comparison of CMT between groups [ 2 , 3 ].…”