Comparative study of the influence of tadalafil and doxazosin on the rate of oxygen consumption by prostate tissue in Sprague-Dawley rats and in white outbred rats. Possible clinical consequences of unstudied pharmacological effect in men with lower urinary tract symptoms

Lobkarev, Alexey; Khafizyanova, Rofija; Lobkarev, Oleg; Borovskaya, Tatyana; Vychuzhanina, Anna; Grigoreva, Valeria; Kollantay, Olesya

doi:10.18411/phol-2020-1-144-149

2020

DOI: 10.18411/phol-2020-1-144-149

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Comparative study of the influence of tadalafil and doxazosin on the rate of oxygen consumption by prostate tissue in Sprague-Dawley rats and in white outbred rats. Possible clinical consequences of unstudied pharmacological effect in men with lower urinary tract symptoms

Alexey Lobkarev¹,

Rofija Khafizyanova²,

Oleg Lobkarev³

et al.

Abstract: Objective: to study comparatively the influence of tadalafil and doxazosin on the rate of oxygen consumption (ROC) by prostate tissue in prague-Dawley rats (SDR) and in white outbred rats (WOR).Methods: 30 SDR and 50 WOR were used. 30 SDR were randomized into 3 groups. 10 SDR (1 st group) under general anesthesia (GA) received doxazosin 0.25 mg intragastrically. 10 SDR (2 nd group) under GA received tadalafil 0.22 mg intragastrically. 10 SDR (3 d group -SDR-control) under GA no drugs received. 50 WOR were rand… Show more

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Influence of Pumpkin Seed Oil on the Rate of Oxygen Consumption by the Prostate Tissue

A.O.

Khafiz’yanova

2023

Vestnik "Biomedicina i sociologiya"

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Despite a long and successful experience with the use of pumpkin seed oil (PSO) in patients with chronic prostatitis (CP), the pharmacodynamics of PSO is not fully understood. We hypothesized that pumpkin seeds and PSO contain pharmacologically active substances that are able to influence on the rate of oxygen consumption (ROC) by the prostate tissue, which may be a determinant of their effectiveness in men with CP. The aim: to study the effect of eating pumpkin seeds, containing PSO, on the ROC of the prostate tissue in white outbred rats. Materials and methods. The control group consisted of 16 outbred male rats. The experimental group consisted of 6 white outbred male rats, which on the eve received, in addition to the standard diet, pumpkin seeds without restriction. Thus, 22 adult outbred male rats were used in the study. The ROC of the prostate tissue was measured by an optical sensor of dissolved oxygen with a DKTP-03 thermoelectric converter. A prostatectomy was performed under anesthesia. Immediately after that, prostate tissue weighing 0.5 g was placed in a beaker, filled with 15.0 ml of 0.9% sodium chloride solution at a temperature of 36.6 °C. An optical oxygen sensor DKTP-03 connected to an oxygen analyzer "Expert-009" was placed in a beaker and the tightness was created. The analyzer showed the concentration of dissolved molecular oxygen (CDO2) in a 0.9% solution of sodium chloride, expressed in mg / l. We recorded the CDO2 readings every minute from the beginning of the experiments (0 minutes) to their end (60 minutes). Results and conclusion. we have found for the first time that PSO statistically significantly increases the ROC in rat prostate tissue (p < 0.05).

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Influence of Pumpkin Seed Oil on the Rate of Oxygen Consumption by the Prostate Tissue

A.O.

Khafiz’yanova

2023

Vestnik "Biomedicina i sociologiya"

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Discovery of an Original Model to Study the Influence of Pharmacologically Active Substances on the Rate of Oxygen Consumption in the Prostate Tissue

A.O.

2023

Vestnik "Biomedicina i sociologiya"

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The article provides a review of foreign scientific literature on existing approaches in scientists' ideas about the quantum theory of brain physics and the theory of quantum-like consciousness. It is shown that in recent years, physics and psychology have made important scientific advances; the emergence of new tools has led to the development of neuroscience, which makes it possible to study the state of the brain when known mental functions are preserved or impaired. The use of mathematical methods has made it possible to develop computational models that describe the fundamental functions of the brain and implement them in technological applications. The most pressing issues of modern research in the field of mental processes of the brain, such as perception, cognition, emotions, consciousness and learning, researchers call the problems of the universal properties of human behavior in various conditions and cultures; the potential of computational psychiatry to predict, understand and treat mental disorders; neural mechanisms of influence on mental content at higher levels of organization of the hierarchical brain; mechanisms of the emergence of abstract ideas from sensorimotor accidents, etc. Currently, in understanding the cognitive processes of the brain, perception, understanding, cognition, mental lexicon, understanding the generation and nature of emotions, memory, learning, etc. A number of researchers use the theory of quantum or quantum-like consciousness. Research in this area is both empirical and theoretical in nature, with the postulates of the theory being considered mainly related to quantum physics due to the lack of other areas in which quantum-like properties are supposedly manifested. It is believed that despite modern advances in artificial intelligence models, neural networks cannot reach the level of the human brain, partly due to differences in the way information is encoded and processed. In order to develop the potential of brain-based artificial intelligence, quantum neural networks are proposed that are similar to the mechanisms and phenomena in the brain. Interactions between biologically important molecules in the brain may underlie the quantum metalanguage that governs the behavior of humans and animals.

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Comparative study of the influence of tadalafil and doxazosin on the rate of oxygen consumption by prostate tissue in Sprague-Dawley rats and in white outbred rats. Possible clinical consequences of unstudied pharmacological effect in men with lower urinary tract symptoms

Cited by 2 publications

References 5 publications

Influence of Pumpkin Seed Oil on the Rate of Oxygen Consumption by the Prostate Tissue

Influence of Pumpkin Seed Oil on the Rate of Oxygen Consumption by the Prostate Tissue

Discovery of an Original Model to Study the Influence of Pharmacologically Active Substances on the Rate of Oxygen Consumption in the Prostate Tissue

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