Comparative study of the nerve endings of the outer and inner hair cells in the organ of Corti

Rama, J; Morales, Jesús Boadas; Sánchez, Gloria Carmona

doi:10.1017/s0022215100089945

Cited by 2 publications

(1 citation statement)

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“…Previous results 14 have shown that, as well as adrenergic innervation, the organ of Corti receives sensory input via afferent and efferent nerve fibres within the central nervous system. The efferent nerve fibres are distributed mainly among the outer hair cells, with which they make synaptic contacts by means of the nerve endings identified by Engström 15 (the morphological aspects of which have since been extensively studied) 16 . Functionally, the medial efferent fascicle carries signals capable of influencing the sensitivity of the peripheral auditory system, specifically with respect to frequency, through its action on the dynamics of the basilar membrane (analysed by means of in vivo studies) 17 …”

Section: Discussionmentioning

confidence: 99%

Low frequency electromagnetic radiation and hearing

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Low frequency electromagnetic radiation and hearing

et al. 2009

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Recording and labeling at a site along the cochlea shows alignment of medial olivocochlear and auditory nerve tonotopic mappings

Brown

2016

Journal of Neurophysiology

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Medial olivocochlear (MOC) neurons provide an efferent innervation to outer hair cells (OHCs) of the cochlea, but their tonotopic mapping is incompletely known. In the present study of anesthetized guinea pigs, the MOC mapping was investigated using in vivo, extracellular recording, and labeling at a site along the cochlear course of the axons. The MOC axons enter the cochlea at its base and spiral apically, successively turning out to innervate OHCs according to their characteristic frequencies (CFs). Recordings made at a site in the cochlear basal turn yielded a distribution of MOC CFs with an upper limit, or "edge," due to usually absent higher-CF axons that presumably innervate more basal locations. The CFs at the edge, normalized across preparations, were equal to the CFs of the auditory nerve fibers (ANFs) at the recording sites (near 16 kHz). Corresponding anatomical data from extracellular injections showed spiraling MOC axons giving rise to an edge of labeling at the position of a narrow band of labeled ANFs. Overall, the edges of the MOC CFs and labeling, with their correspondences to ANFs, suggest similar tonotopic mappings of these efferent and afferent fibers, at least in the cochlear basal turn. They also suggest that MOC axons miss much of the position of the more basally located cochlear amplifier appropriate for their CF; instead, the MOC innervation may be optimized for protection from damage by acoustic overstimulation.

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Comparative study of the nerve endings of the outer and inner hair cells in the organ of Corti

Abstract: The synaptic region and nerve endings have been studied both in the outer and inner hair cells by using optic and electron microscopy, nerve staining and Acetyl Cholinesterase activity. The findings are described, with a discussion of the results.

Cited by 2 publications

References 11 publications

Low frequency electromagnetic radiation and hearing

Low frequency electromagnetic radiation and hearing

Recording and labeling at a site along the cochlea shows alignment of medial olivocochlear and auditory nerve tonotopic mappings

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