Comparative study of three different membranes for guided bone regeneration of rat cranial defects

Dupoirieux, L.; Pourquier, Didier; Picot, Marie‐Christine; Neves, Marcos A.

doi:10.1054/ijom.2000.0011

Cited by 130 publications

(131 citation statements)

References 21 publications

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“…For instance, regarding XRD analysis, this is a powerful method used to investigate crystalline structures, whether looking into the size of the crystals embedded in the micro/nanostructure, as well as their atomic arrangement. The authors have used this technique in a previous study, while developing substitute materials for bone graft implants [29]. Fereydoon et al, [30] have used XRD analysis to characterize the crystalline structure of cast films of nylon and its nanocomposite with 4% clay.…”

Section: Morphological Analyses Of Composite Filmsmentioning

confidence: 99%

Development and Characterization of Chitosan-Nanoclay Composite Films for Enhanced Gas Barrier and Mechanical Properties

Neves¹

2016

FSN

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Chitosan-nanoclay composite films were investigated in this study, aiming to develop films with enhanced mechanical properties, and high-barrier against gas exchange, foreseeing their application as base material for food packaging. The effect of nanoclay concentration on the Water Vapor Permeability (WVP), Water Vapor Transmission (WVTR), mechanical properties and morphology of surface structure of the composite films were evaluated. Chitosan-based composite films were prepared using a solvent-casting method, also incorporating of bentonite nanoclay in the filmogenic mixture. As for the results obtained, nanoclay concentration greatly affected the WVP of the casted composite films. The lowest WVTR was observed in films consisting of 2wt% chitosan and 3wt% nanoclay. By adding up to 3wt% bentonite nanoclay, the Tensile Strength (TS) of the composite films could be enhanced up to 60%, as comparted to films prepared using 2wt% chitosan alone. Seemingly, the elongation of composite films decreased with increasing nanoclay content. Moreover, the combination of nanoclay 3wt% and chitosan 2wt% resulted in more resistant films (higher TS) and with reduced gas transfer (lower WVP) and Elongation (E). The results suggest that films containing 3% nanoclay not only decreased the WVP by aiding the role of chitosan, but also modified the rheological properties of resulting film. Therefore, the combination of chitosan and nanoclay may lead to the formation of novel composite films with enhanced mechanical properties and selective gas barrier, a promising material for food packaging applications.

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Section: Morphological Analyses Of Composite Filmsmentioning

confidence: 99%

Development and Characterization of Chitosan-Nanoclay Composite Films for Enhanced Gas Barrier and Mechanical Properties

Neves¹

2016

FSN

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“…The technique of guided tissue regeneration (GTR) has evolved over recent years in an attempt to achieve periodontal repair [2]. The technique of GTR uses a membrane to cover the periodontal defect, which isolates the defect area from the overlying gingival soft tissue, thus allowing mesenchymal cells from the periodontal ligament and bone to populate the wound and stimulate periodontal tissue regeneration [3,4].…”

Section: Introductionmentioning

confidence: 99%

Effects of hydroxyapatite and PDGF concentrations on osteoblast growth in a nanohydroxyapatite-polylactic acid composite for guided tissue regeneration

Talal

McKay

Tanner

et al. 2013

J Mater Sci: Mater Med

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The technique of guided tissue regeneration (GTR) has evolved over recent years in an attempt to achieve periodontal tissue regeneration by the use of a barrier membrane. However, there are significant limitations in the currently available membranes and overall outcomes may be limited. A degradable composite material was investigated as a potential GTR membrane material. Polylactic acid (PLA) and nano-hydroxyapatite (nHA) composite was analysed as a potential GTR membrane material. Its bioactive potential and suitability as carrier system for growth factors were assessed. The effect of nHA concentrations and the addition of platelet derived growth factor (PDGF) on osteoblast proliferation and differentiation was investigated. The bioactivity was dependent on the nHA concentration in the films, with more apatite deposited on films containing higher nHA content. Osteoblasts proliferated well on samples containing low nHA content and differentiated on films with higher nHA content. The composite films were able to deliver PDGF and cell proliferation increased on samples that were pre-absorbed with the growth factor. nHA-PLA composite films are able to deliver active PDGF. In addition the bioactivity and cell differentiation was higher on films containing more nHA. The use of a nHA-PLA composite material containing a high concentration of nHA may be a useful material for GTR membrane as it will not only act as a barrier, but may also be able to enhance bone regeneration by delivery of biologically active molecules.

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“…GBR membranes should satisfy several criteria: they should control the intrusion of soft tissue into the bone site, have surface roughness that enables good integration with the surrounding tissues and thus enhances their stability (i.e., tissue integration), have high mechanical strength to maintain the shape of the defect to be reconstructed, and enhance the formation of bone 3,4) . Nondegradable expanded-polytetrafluoroethylene (e-PTFE) 5) , biodegradable materials such as collagen 5) , and synthetic biodegradable polymers such as poly(lactic acid) (PLA) or poly(lactic-co-glycolic acid) (PLGA) 2) , have been used as membrane materials. Although these membranes work as barriers that control the intrusion of soft tissues, they do not show any bone-formationenhancing ability.…”

Section: Introductionmentioning

confidence: 99%

Effect of preparation route on the degradation behavior and ion releasability of siloxane-poly(lactic acid)-vaterite hybrid nonwoven fabrics for guided bone regeneration

Wakita

Nakamura

Ota³

et al. 2011

Dent. Mater. J.

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Two types of nonwoven fabric, consisting of siloxane-doped vaterite (SiV) and poly(lactic acid) (PLA), for guided bone regeneration (GBR) were prepared by an electrospinning. One of the fabrics, SiV-PLA(M), was derived from PLA mixed with the solution of SiV dispersed in chloroform. Another one, SiV-PLA(K), was derived from a composite prepared by kneading SiV and PLA while heating at 200°C. The SiV-PLA(K) fabric shows higher degradability in dilute NaOH aq. than the SiV-PLA(M) fabric. To improve the cellular compatibility of the fabric, the fibers were coated with hydroxyapatite (HA) by soaking in simulated body fluid. The HA-coated SiV-PLA(K) fabric showed the release of silicate ions; the amount was reduced by 1/5 to 1/8 compared with that of the HA-coated SiV-PLA(M) fabric, and the excessive release was controlled. The preparation route of kneading at 200°C led to formation of a fabric with degradation behavior and ion releasability effective for bone regeneration.

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Comparative study of three different membranes for guided bone regeneration of rat cranial defects

Cited by 130 publications

References 21 publications

Development and Characterization of Chitosan-Nanoclay Composite Films for Enhanced Gas Barrier and Mechanical Properties

Development and Characterization of Chitosan-Nanoclay Composite Films for Enhanced Gas Barrier and Mechanical Properties

Effects of hydroxyapatite and PDGF concentrations on osteoblast growth in a nanohydroxyapatite-polylactic acid composite for guided tissue regeneration

Effect of preparation route on the degradation behavior and ion releasability of siloxane-poly(lactic acid)-vaterite hybrid nonwoven fabrics for guided bone regeneration

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