Comparative study of three types of mesenchymal stem cell to differentiate into pancreatic β‑like cells <i>in vitro</i>

Mo, Yunfang; Wang, Zejian; Gao, Jian; Yan, Yan; Ren, Huaijuan; Zhang, Fengli; Qi, Nianmin; Chen, Yantian

doi:10.3892/etm.2021.10368

Cited by 7 publications

(2 citation statements)

References 44 publications

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“…Previous studies have demonstrated that most efforts to intervene in the pathogenesis of T1D involve immune-based therapies, with the primary endpoint focused on β-cell function maintenance [138]. DPSCs have been reported to differentiate into β islet-like cells and can be used for autologous stem cell therapy in T1D [139][140][141].…”

Section: Type 1 Diabetesmentioning

confidence: 99%

Immunomodulatory Mechanism and Potential Application of Dental Pulp-Derived Stem Cells in Immune-Mediated Diseases

Tian

Tang

et al. 2023

IJMS

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Dental pulp stem cells (DPSCs) are mesenchymal stem cells (MSCs) derived from dental pulp tissue, which have high self-renewal ability and multi-lineage differentiation potential. With the discovery of the immunoregulatory ability of stem cells, DPSCs have attracted much attention because they have similar or even better immunomodulatory effects than MSCs from other sources. DPSCs and their exosomes can exert an immunomodulatory ability by acting on target immune cells to regulate cytokines. DPSCs can also migrate to the lesion site to differentiate into target cells to repair the injured tissue, and play an important role in tissue regeneration. The aim of this review is to summarize the molecular mechanism and target cells of the immunomodulatory effects of DPSCs, and the latest advances in preclinical research in the treatment of various immune-mediated diseases, providing new reflections for their clinical application. DPSCs may be a promising source of stem cells for the treatment of immune-mediated diseases.

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Section: Type 1 Diabetesmentioning

confidence: 99%

Immunomodulatory Mechanism and Potential Application of Dental Pulp-Derived Stem Cells in Immune-Mediated Diseases

Tian

Tang

et al. 2023

IJMS

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“…DP-MSCs are derived from exfoliated human deciduous teeth and have the properties of being easy to obtain with minimal donor injury. In a study by Mo et al DP-MSCs revealed the ability to differentiate into pancreatic β-cells; nevertheless, before proceeding with larger-scale investigations to firmly establish this approach, it is necessary to devise procedures for optimal β-cell differentiation in-vivo [ 65 ].…”

Section: Reviewmentioning

confidence: 99%

The Role of Mesenchymal Stem Cells in the Treatment of Type 1 Diabetes

Jayasinghe¹,

Prathiraja²,

Perera³

et al. 2022

Cureus

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Type 1 diabetes (T1D) is a chronic disease characterized by inadequate or absent insulin production due to the autoimmune destruction of beta (β) cells in the pancreas. It was once called "juvenile diabetes" since the disease frequently occurs in children, but it can also develop in adults. According to the International Diabetes Federation, an estimated 700 million adults will suffer from diabetes by 2045. Although the exact cause of diabetes remains unknown, it is hypothesized that genetic factors, environmental factors, and exposure to certain viruses play a role in the development of T1D. To date, exogenous insulin is the most common treatment for T1D. However, it is not a cure for the disease. Islet cell transplantation and pancreatic transplantation are two additional treatments that have gained popularity in recent years, but their clinical application may be limited by the need for high doses of immunosuppressants, the rarity of human cadaveric islets, and the need for extensive surgery in pancreatic transplantation. Mesenchymal stem cells (MSCs) are a highly promising novel treatment for T1D and their discovery has advanced biological sciences by allowing for modification of cell fate and the development of higher-order cellular structures. They play an essential role in lowering levels of fasting blood sugar, hemoglobin A1c, and C-peptide, and in treating microvascular complications associated with T1D. However, some of the disadvantages of its use in clinical practice are limited to its method of collection, proliferation rate, cell activity with age, and the risk of tumour formation identified in some studies. Large-scale studies are required to discover the mechanism of action of MSCs after administration as well as the optimal route, dose, and timing to maximize the benefits to patients. This article focuses primarily on the role of MSCs in the treatment of T1D and compares the feasibility, benefits, and drawbacks of MSCs in the treatment of T1D.

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Body fluid-derived stem cells — an untapped stem cell source in genitourinary regeneration

Huang

et al. 2023

Nat Rev Urol

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Comparative study of three types of mesenchymal stem cell to differentiate into pancreatic β‑like cells in vitro

Cited by 7 publications

References 44 publications

Immunomodulatory Mechanism and Potential Application of Dental Pulp-Derived Stem Cells in Immune-Mediated Diseases

Immunomodulatory Mechanism and Potential Application of Dental Pulp-Derived Stem Cells in Immune-Mediated Diseases

The Role of Mesenchymal Stem Cells in the Treatment of Type 1 Diabetes

Body fluid-derived stem cells — an untapped stem cell source in genitourinary regeneration

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