Comparative study of touchable plasma devices on transdermal drug delivery

Tian, Di; Lv, Yang; Nie, Lanlan; Li, Xu; Liu, Jialin; Lü, Xinpei

doi:10.1002/ppap.202200216

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…The plasma discharge can disrupt and possibly even perforate the skin, thereby creating channels that allow for rapid and effective diffusion of therapeutic formulations into the skin. As these perforations are small, they heal and close rapidly, allowing for effective drug delivery [112]. The technique is pain-free, unlike traditional electroporation approaches [113].…”

Section: Combinations Of Plasma With Traditional Pharmaceuticalsmentioning

confidence: 99%

Recent Developments in the Use of Plasma in Medical Applications

O’Neill,

Bourke

2024

Plasma

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A detailed review of the scientific literature was undertaken to examine the most recent developments in plasma processing in the field of medicine. The first part of the review includes a detailed breakdown of the different types of coatings that can be applied onto medical devices using plasma, with a specific focus on antimicrobial surfaces. The developments in plasma-deposited biocompatibles, drug delivery and adhesive coatings in 2023 are described, and specific applications in additive manufacturing are highlighted. The use of plasma and plasma-activated liquids as standalone therapeutics continues to evolve, and pertinent advances in this field are described. In addition, the combination of plasma medicine with conventional pharmaceutical interventions is reviewed, and key emerging trends are highlighted, including the use of plasma to enhance drug delivery directly into tissue. The potential synergies between plasma medicine and chemotherapeutics for oncology and infection treatment are a growing area, and recent advancements are noted. Finally, the use of plasma to control excess antibiotics and to intentionally degrade such materials in waste streams is described.

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Section: Combinations Of Plasma With Traditional Pharmaceuticalsmentioning

confidence: 99%

Recent Developments in the Use of Plasma in Medical Applications

O’Neill,

Bourke

2024

Plasma

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“…Finally, Tian et al investigate the efficiency and safety of touchable plasma jets for transdermal drug delivery, assessing their impact on skin tissue. [10] This research provides valuable insights into the development of plasma-based delivery systems and their potential as noninvasive alternatives for drug administration.…”

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confidence: 99%

Special issue: Plasma Medicine ‐ part I

Canal

Noguera

Tampieri

2023

Plasma Processes & Polymers

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High time resolution diagnosis of electron density in helium plasma jets with impurity gas

Li,

Wang,

Nie

et al. 2024

Physics of Plasmas

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Atmospheric pressure helium plasma jets are widely used in biomedical applications. Researchers normally introduce small amounts of nitrogen and oxygen (0.2–1.0%) into helium to enhance the electron density and electron energy, thus increasing the concentration of active species in plasma. To further explore why the combination of impurity gases N2/O2 leads to an increase in the electron density from the discharge mechanism, we used a microwave Rayleigh scattering method with excellent time-varying characteristics to monitor the temporal electron density changes when different concentrations of N2/O2 were mixed. The research revealed that even trace amounts of N2/O2 (0.2%) can increase the peak electron density, with this effect being more pronounced when N2 is added, increasing from 3.3 × 1019 to 4.6 × 1019 m−3 in pure helium. As the concentration increases, the introduction of O2 leads to a rapid decrease in the electron density. When 1.0% oxygen is mixed, the electron density decreases from 3.3 × 1019 to 2.4 × 1019 m−3. However, the situation is different when N2 is added, at 0.5% proportion of nitrogen, the electron density increases to its maximum at 6.5 × 1019 m−3. These effects are due to the electronegativity of the oxygen-containing particles or the Penning ionization related to excited nitrogen species.

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Comparative study of touchable plasma devices on transdermal drug delivery

Cited by 4 publications

References 38 publications

Recent Developments in the Use of Plasma in Medical Applications

Recent Developments in the Use of Plasma in Medical Applications

Special issue: Plasma Medicine ‐ part I

High time resolution diagnosis of electron density in helium plasma jets with impurity gas

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