Comparative study of transepidermal water loss in patients with and without hyperhidrosis by closed-chamber measurer in an air-conditioned environment

Miotto, André; Honda, Pedro Augusto Antunes; Bachichi, Thiago Gangi; Holanda, Caio Santos; Neto, Ernesto Evangelista; Perfeito, João Aléssio Juliano; Leão, Luiz Eduardo Villaça; Costa, Altair da Silva

doi:10.31744/einstein_journal/2018ao4312

Cited by 7 publications

(7 citation statements)

References 18 publications

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“…A pele apresenta uma estrutura variada de acordo com a região do corpo (Pinnagoda et al, 1990;Conti et al, 1996). Ademais, foi verificado diferença na aferição da TEWL com o equipamento Vaporemeter principalmente nas mãos, pés e axilas entre pacientes com e sem hiperidrose, em ambiente de temperatura controlada (Miotto et al, 2018). Há uma possível diferença entre sexos, com resultados maiores de TEWL em homens e de acordo com a idade, com redução da TEWL em idosos (Levin & Maibach, 2005;Miotto et al, 2018).…”

Section: Discussionunclassified

“…Foram feitas correlações entre a TEWL, hidratação e nível causal de sebo com os valores das regiões anatômicas do estudo e para todas as medições feitas em conjunto (93 indivíduos e 14 locais anatômicos), mas não mostraram relevância (Miotto et al, 2018). Em nosso estudo, foi verificada relevância estatística entre a umidade e a elasticidade da pele, o que não ocorreu com a oleosidade.…”

Section: Discussionunclassified

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Filme hidrolipídico e elasticidade cutânea em crianças e adolescentes de Vassouras, Rio de Janeiro: estudo piloto quantitativo

Pereira

Neves

Carvalho

et al. 2021

RSD

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Avaliar o FH, a TEWL e elasticidade cutânea em crianças e adolescentes por meio de variáveis como umidade e oleosidade da pele. Trata-se de um estudo piloto observacional, transversal e de natureza quantitativa realizado em escola privada de Vassouras em março de 2020, com 27 alunos de 11 a 15 anos. Os resultados demonstraram equilíbrio FH razoável na face, ruim na nuca e variação de razoável a ruim nos membros superiores e de bom a ruim nos inferiores. A elasticidade se mostrou não favorável na face, nuca e na maior parte dos membros superiores e inferiores. Os valores de TEWL variaram de acordo com a região e decorrem de mudanças na umidade e oleosidade, enquanto a elasticidade alterou devido à umidade.

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Section: Discussionunclassified

Filme hidrolipídico e elasticidade cutânea em crianças e adolescentes de Vassouras, Rio de Janeiro: estudo piloto quantitativo

Pereira

Neves

Carvalho

et al. 2021

RSD

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“…Hyperhidrosis is defined as excessive sweating [21] and is present in various conditions including primary palmoplantar hyperhidrosis [23,24], overall body hyperhidrosis [21], and cystic fibrosis (CF) [22].…”

Section: Eccrine Gland Contributions To Tewl Values In Hyperhidrosismentioning

confidence: 99%

“…In addition, beyond local skin temperature triggering sweat gland activation, there are also a variety of systemic activators [16][17][18][19][20]. These include cholinergic agonists, sympathetic nervous system activation, emotional stress, and various medical conditions such as hyperhidrosis and cystic fibrosis [10,[21][22][23][24]. These conditions and processes affect eccrine gland activation and thus cause variable effects on TEWL measurements.…”

Section: Introductionmentioning

confidence: 99%

Impacts of Skin Eccrine Glands on the Measured Values of Transepidermal Water Loss

Schwab¹,

Flora²,

Mayrovitz³

2022

Cureus

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Transepidermal water loss (TEWL) is widely used to assess and quantify skin insensible water loss to assess skin's barrier function integrity. Low TEWL values are normally indicative of intact skin and a healthy functional barrier, whereas an increased TEWL reveals a disturbed or disrupted skin barrier. Because most skin sites at which these measurements are made have eccrine glands present, the contribution of the sweat gland activity to these measurements is variable and, in most cases, unknown. The separation between the contribution of water loss that is reflective of the skin barrier integrity versus that contributed via eccrine activation is not easy and is made more difficult since both components increase with increasing skin and environmental temperature. Endogenous factors that impact eccrine sweat gland activity include sympathetic nervous system activity, emotional stress, physical activity, eccrine gland density, and age. Exogenous factors that impact eccrine gland activity include ambient temperature and humidity and the climate where one resides. The aforementioned variables impact eccrine gland activity positively or negatively and therefore alter TEWL values accordingly. Although it may be theoretically possible to control all these factors, the difficulty in doing so results in only a few being controlled during most TEWL measurements. Such confounding processes may have impacted historical TEWL reference ranges and values previously reported. Thus, the impact of eccrine activation on standardly measured TEWL values is at this juncture unclear and may be a component contributing to some reported variability in TEWL values. To help clarify the issues, a literature review was conducted to investigate and summarize relevant prior research efforts and outcomes with respect to ways to consider eccrine activity in TEWL measurements and estimate the contribution of eccrine gland activity to TEWL values. Online databases such as Excerpta Medica Database (EMBASE), Public/Publisher Medline (PubMed), Elton B. Stephans Company (EBSCO), Google Scholar, and Wiley Online Library were searched with "transepidermal water loss" or "TEWL" in the title combined with "eccrine glands" or "sweat" anywhere in the text. The present findings indicate a multiplicity of biological and environmental variables impacting eccrine gland activity and thereby potentially affecting measured TEWL values. Even if laboratory conditions adhere to various guidelines and recommendations, it is not yet possible to separate the eccrine activation component from the parameter of true interest in the assessment of the skin's physiological barrier function except for full gland deactivation. The amount that such eccrine gland activation impacts the measured value of TEWL is generally not determined using currently available methods and the only sure way to eliminate a confounding effect is to inactivate the glands during such TEWL measurements. Because such eccrine gland deactivating approach is not usually desirable or even possible, other ...

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“…-паперу до 0,01 г. При блашинг-синдромі проводили капіляроскопію.З метою визначення об'єктивної оцінки ступеня тяжкості гіпергідрозу проводили вимірювання трансепідермальної втрати рідини (TEWL-метрію) до та після операції (через 1 міс) за допомогою апарату Tewameter TM 300 з відкритою камерою. Одиниця виміру -г/год/м 2[12,13]. За ступенем трансепідермальної втрати рідини визначали стан шкіри: 0-10 -відмінний стан, 10-15 -задовільний стан, 15-25 -нормальний стан, 25-30 -напружений стан, >30 -критичний стан.…”

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Treatment outcomes and objectification methods of the thoracoscopic sympathectomy in patients with focal hyperhidrosis and blushing syndrome

Eroshkin¹,

Sokolov²,

Omelchenko³

et al. 2021

Ukr Neurosurg J

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Uniportal video-assisted thoracoscopic sympathectomy (VATS) is an effective minimally invasive surgical method of choice for the treatment of primary focal hyperhidrosis and blushing syndrome due to uncontrolled operation of the sympathetic nervous system. The aim of this study was to provide an objective assessment of the improvement in the quality of life of patients with primary focal hyperhidrosis and blushing syndrome after bilateral monoport video-assisted thoracoscopic sympathectomy. Materials and methods. The results of surgical treatment were performed for 62 patients aged 17 to 42 years, 26 men and 36 women with a diagnosis of primary focal hyperhidrosis of the extremities and blushing syndrome. All patients underwent bilateral uniport video-assisted thoracoscopic sympathectomy. Patients are divided into 3 groups depending on the level of coagulation of the sympathetic trunk: the first group of the study (n = 9) includes patients after bilateral uniport sympathectomy at the level of R3 (isolated palmar hyperhidrosis), the second (n = 31) - at the level of R3-R4 (palmar and axillary hyperhidrosis), the third group (n = 22) - at the level of R2 (blushing syndrome). Results. In this study, coagulation and separation of the sympathetic trunk through a single port using a silicone port was performed. An excellent clinical result was achieved due to the minimally invasive operation - all 62 patients (100%) were satisfied with the achievement of a rapid stable effect. According to the results of the Dermatology Life Quality Index DLQI (1 month after surgery), the best quality of life measures were observed in patients who underwent separation of the sympathetic trunk at the R3 level – improvement from 20.3 ± 5.9 points to 0.8 ± 0.8 points. After the operation at the R3-R4 level scores the quality of life decreased from 22.77 ± 5.4 points to 2.3 ± 1.3 points, and at the level of R2 - from 16.5 points (QI 14 points - QIII 20 points) to 2 points (QI 1 point - QIII 3 points) p <0.001). There was a difference in quality of life measures in our three groups of patients according to the severity of the disease before surgery. The lowest quality of life was determined in patients with the 4th degree of severity (33 people) and was 26.0 points (QI 23.0 points - QIII 27.3 points) compared with patients with 2d and 3d degrees of severity, 10.0 points (QI 7.7 points - QIII 10.0 points) and 17.0 points (QI 14.0 points - QIII 19.5 points) respectively (p <0.001). After a single-port VATS in three groups there was an increase in quality of life measure, regardless of the severity of the disease before surgery. Conclusions. The most highly specific tests that allow to determine an objective assessment of the severity of the disease and a real assessment of the effectiveness of surgical treatment for hyperhidrosis was TEWL-metry, for blushing syndrome – capillaroscopy. VATS is an effective method of treating patients with hyperhidrosis and blushing syndrome, which significantly improves the quality of life according to the results of the Dermatological Index of Life Quality DLQI (p <0.001) questionnaire.

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Comparative study of transepidermal water loss in patients with and without hyperhidrosis by closed-chamber measurer in an air-conditioned environment

Cited by 7 publications

References 18 publications

Filme hidrolipídico e elasticidade cutânea em crianças e adolescentes de Vassouras, Rio de Janeiro: estudo piloto quantitativo

Filme hidrolipídico e elasticidade cutânea em crianças e adolescentes de Vassouras, Rio de Janeiro: estudo piloto quantitativo

Impacts of Skin Eccrine Glands on the Measured Values of Transepidermal Water Loss

Treatment outcomes and objectification methods of the thoracoscopic sympathectomy in patients with focal hyperhidrosis and blushing syndrome

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