Comparative Study of Two Different TRUS–Guided Sextant Biopsy Techniques in Detecting Prostate Cancer in One Biopsy Session

Spatial Distribution of Prostate Cancers Undetected on Initial Needle Biopsies

“…In another recent investigation, Presti et al [4]stressed the fact that the majority of cancers usually arise in the peripheral zone. As the apical region of the prostate represents an almost ‘purely peripheral zone’, it seems logical that concentration of biopsy on this region might increase detection rate, if a small carcinoma still is in an early stage of development [22]. …”

Patients' tolerance and early complications of transrectal sonographically guided prostate biopsy: Prospective study of 300 patients

“…The overall complication rate was small in our study compared with other series. 2,3,15,18,27,28 In our experience, the presence of anorectal anomalies such as anal stenosis posthemorrhoidectomy or active diseases such as fistula-in-ano or fissue-in-ano makes TRS-guided prostate biopsy a particularly painful procedure. These patients require some form of local anesthestic prior to the procedure.…”

“…Local application of anesthetics has been reported by several authors with varying results. 9,27 There are no reports of the effect of local anesthesia in patients with local anal/perianal disease, however.…”

Early Detection of Prostate Cancer in Germany: A Study Using Digital Rectal Examination and 4.0 ng/ml Prostate–Specific Antigen as Cutoff

“…Compared to previous studies [2, 9], the presented PPV of PSA alone (17%) seems rather low. In part, this may be due to the biopsy technique [13]or the number of biopsies taken [12]. Only 47% of the men with suspicious findings underwent systematic sextant biopsy with 6 tissue cores, and 46% were biopsied less than 6 times.…”

“…The redetection of cancer using 8 biopsies was 75% versus 41% using only 4 biopsies. To further optimize the sensitivity of 6–core biopsy, it is suggested to biopsy preferably the apex in a transverse plane [13]. …”