Comparative study of two versatile multi-analyte chromatographic methods for determination of diacerein together with four non-steroidal anti-inflammatory drugs: Greenness appraisal using Analytical Eco-Scale and AGREE metrics

An eco‐friendly multi‐analyte high‐performance thin layer chromatographic densitometric determination of amoxicillin, metronidazole, and famotidine in their ternary mixtures and simulated gastric juice: A promising protocol for eradicating Helicobacter pylori

“…It is clear that the greenness assessment with the descriptive AGREE tool approves the superior degree of eco‐friendliness of the proposed HPTLC method which could not be assessed using the other assessment tools. This could be attributed to the superiority of the most recent AGREE tool, compared with ESA, NEMI, and GAPI, since the former includes the comprehensive assessment of the 12 GAC principles [37]. For the proposed HPTLC method, only one section in the perimeter was red (section 11) for the use of toxic solvents representing some sort of threats, while three sections were colored yellow for waste production of about 10 ml (section 7), being LC technique with most energy production (section 9), and the biological origin of some of the reagents used (section 10).…”

Eco-friendly stability-indicating HPTLC micro-determination of the first FDA approved SARS-CoV-2 antiviral prodrug Remdesivir: Study of degradation kinetics and structural elucidation of the degradants using HPTLC-MS

“…For preliminary judgement on the greenness of the developed method we employed the simple semi-quantitative Analytical Eco-scale (AES) tool ( Gałuszka et al, 2012 ). While, for the sake of obtaining a more comprehensive comparison between our method and different published analytical procedures in terms of their ecological effect, it is highly recommended to combine more than one GAC metric, where synergistic results allow for rational ranking of these procedures ( El-Kafrawy et al, 2022a ; El-Kafrawy et al, 2022b ). This is usually achieved when specially combining the inclusive Green Analytical Procedure Index (GAPI) metric ( Płotka-Wasylka, 2018 ) and the more informative analytical greenness (AGREE) tool ( Pena-Pereira et al, 2020 ).…”

Sustainable spectrophotometric determination of antihypertensive medicines reducing COVID-19 risk via paired wavelength data processing technique - Assessment of purity, greenness and whiteness

“…The concept of White Analytical Chemistry (WAC) is presented as an extension of Green Analytical Chemistry (GAC) ( El-Kafrawy et al, 2022 ; Gałuszka et al, 2013 ). In addition to green aspects, WAC takes into account other key criteria affecting the quality of the method, analytical (red) and practical (blue).…”