This perspective paper explores the concept of multispecies design in architecture, focusing on the building scale. Historically, architects have prioritized human needs, neglecting nature’s integration in urban settings, leading to environmental and social challenges. To address these issues, a new multispecies approach that promotes the integration of ecological knowledge into architectural design has evolved. This paper aims to map existing concepts, challenges, and gaps in this novel multispecies approach, focusing on the building scale design process and suggests a roadmap for its implementation. This paper analyzes the existing literature and current architectural practices. This analysis is complemented by the findings from an architectural design studio that have highlighted real-world challenges not readily apparent in the literature. By promoting a multispecies architectural paradigm, this research not only underscores a transformative approach to building design but also positions multispecies design as an essential strategy in combatting the challenges of declining biodiversity and escalating climate change.