Comparative Study on in-Vivo Anti-Inflammatory Potential From Leaves of Methanol and Chloroform Extracts of Azadirachta Indica A. Juss and Justicia Adhatoda in Nepal

Abstract

The present study was carried out to evaluate and compare anti- carrageenan induced rat paw edema was adopted for the study of anti-inflammatory activity where adult Wistar albino rats (110-160)gm of either sex were selected for study. Adult rats were divided into 10 groups, carrageenan was injected in hind paw and treated with extract at the standard dose of 200 mg/kg and 400mg/kg. The paw volume was measured at different time intervals i.e. 0,2,4 and 12 hours. Percentage inhibition of inflammation was proportional with the total phenolic content. The result indicates that methanol extract of A. indica has highest anti-inflammatory activity than both extract of J. adhatoda while its chloroform extract has least activity among all extracts.