Comparative study on the inhibitory effects of antioxidant vitamins and radon on carbon tetrachloride-induced hepatopathy

Abstract

We have previously reported that radon inhalation activates anti-oxidative functions and inhibits carbon tetrachloride (CCl4)-induced hepatopathy. It has also been reported that antioxidant vitamins can inhibit CCl4-induced hepatopathy. In the current study, we examined the comparative efficacy of treatment with radon, ascorbic acid and α-tocopherol on CCl4-induced hepatopathy. Mice were subjected to intraperitoneal injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m3 radon for 24 h, or immediately after intraperitoneal injection of ascorbic acid (100, 300, or 500 mg/kg bodyweight) or α-tocopherol (100, 300, or 500 mg/kg bodyweight). We estimated the inhibitory effects on CCl4-induced hepatopathy based on hepatic function-associated parameters, oxidative damage-associated parameters and histological changes. The results revealed that the therapeutic effects of radon inhalation were almost equivalent to treatment with ascorbic acid at a dose of 500 mg/kg or α-tocopherol at a dose of 300 mg/kg. The activities of superoxide dismutase, catalase, and glutathione peroxidase in the liver were significantly higher in mice exposed to radon than in mice treated with CCl4 alone. These findings suggest that radon inhalation has an anti-oxidative effect against CCl4-induced hepatopathy similar to the anti-oxidative effects of ascorbic acid or α-tocopherol due to the induction of anti-oxidative functions.

Effect of Vitamin C against Calcium Carbide Induced Hepatotoxicity

“…They reported that vitamin C normalized levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, blood hydrogen peroxide and malondialdehyde in liver of carbon tetrachloride intoxicated rats. The ability of vitamin C to prevent Carbon tetrachloride induced hepatotoxicity in rats was also reported by some authors (Ademuyiwa et al, 1994;Kataoka et al, 2012).…”

Vitamin C attenuates the toxic effect of aristolochic acid on renal tubular cells via decreasing oxidative stress-mediated cell death pathways

“…However, these substances are not easily available. Vitamin C has anti-oxidative activities and is contained in numerous vegetables and fruits (31)(32)(33). The present study therefore assessed whether vitamin C can suppress AA-induced cytotoxicity to kidney cells.…”

“…N-acetyl cysteine (NAC) and glutathione (GSH), anti-oxidative agents, were studied to prevent cell death through AA treatment (16). Vitamin C is a common nutrient with anti-oxidative properties (31)(32)(33). In the present study, it was hypothesized that vitamin C is able to inhibit AA-induced cytotoxicity.…”

Cognitive deficits and decreased locomotor activity induced by single-walled carbon nanotubes and neuroprotective effects of ascorbic acid

“…These groups were exposed to 0, 3.125, 6.25, and 12.5 mg/kg/day SWCNTs, 23 6.25 mg/ kg/day SWCNTs + 100 mg/kg/day ascorbic acid (block group), and 100 mg/kg/day ascorbic acid. 24 We intravenously injected the suspension daily through the tail vein. 18 Based on the period of ethological analysis we adopted in this study, International Journal of Nanomedicine downloaded from https://www.dovepress.com/ by 44.224.250.200 on 15-Jul-2020 For personal use only.…”