Comparative study on the pregnancy outcomes of in vitro fertilization–embryo transfer between patients with different ovarian responses (a STROBE-compliant article)

Abstract

There have been few studies on large-sample data of cleavage-stage embryo and blastocyst transfers. We compared the pregnancy outcomes of patients with different ovarian responses after the transfer of different numbers of embryos in different developmental stages. Patients were divided into 3 groups including low response group, medium response group, and high response group according to different ovarian responses. Patients in each group were further divided into 4 subgroups including group A: transfer of 1 D3 embryo, group B: transfer of 2 D3 embryos; group C: transfer of 1 D5 blastocyst; and group D: transfer of 2 D5 blastocysts. In low ovarian responders, the implantation rate, clinical pregnancy rate and live birth rate were significantly lower in the group A than in the groups B and C. In medium ovarian responders, the implantation rate was significantly higher, but the multiple pregnancy rate was significantly lower in the group C than in the group B. The multiple pregnancy rate was significantly higher in the group D than in the group C. In high ovarian responders, the implantation rate was significantly lower, but the multiple pregnancy rate was significantly higher in the group B than in group C. Based on the above results, the single blastocyst transfer is preferable for the patients with different ovarian responses.

Comparisons of benefits and risks of single embryo transfer versus double embryo transfer: a systematic review and meta-analysis

“…Forty-five studies [ 2 , 11 , 13 , 15 , 21 , 24 , 28 – 31 , 38 , 39 , 43 , 44 , 48 – 50 , 53 , 54 , 56 – 59 , 62 , 64 , 66 – 69 , 72 , 75 – 77 , 79 – 81 , 85 – 87 , 91 , 93 – 96 , 98 ] were pooled and found that the MPR was significantly lower in the SET group than in the DET group (0.05, 0.04–0.06, I 2 = 2%, P < 0.001) (Supplementary Fig. S2 ).…”

“…S3 ). Forty-three studies [ 11 – 14 , 16 , 19 , 20 , 23 , 28 – 31 , 38 – 44 , 48 , 50 , 51 , 53 , 55 , 57 , 58 , 62 , 64 – 66 , 69 , 72 , 74 , 77 , 79 – 81 , 90 , 91 , 94 , 95 , 98 ] evaluated the miscarriage rates, and no significant difference was found between groups during the overall analysis (15.6% vs. 14.2%, 1.10, 0.95–1.27, I 2 = 30%, P = 0.211), neither in all the conducted subgroups (Supplementary Table S4 ). Seven studies [ 19 , 30 , 39 , 58 , 65 , 81 , 94 ] provided information on perinatal mortality, and no difference was observed (0.3% vs 0.7%, 0.71, 0.25–2.06, I 2 = 0%, P = 0.532).…”

“…Large observational studies focusing on the comparisons of different policies regarding the number of embryos transferred are emerging and do provide valid information [ 26 – 28 ]. The diverse population and large sample size offer the possibility of comprehensive subgroup analyses, involving different ages, embryo stages and embryo quality stratification, etc.…”

The Influence of Chromosomal Polymorphism on Embryo Development and Embryonic Molecular Karyotype in Preimplantation Genetic Testing for Chromosomal Translocation

“…After reaching the standard for downregulation, human chorionic gonadotropin (hCG) (Ovidrel; Merck Sereno), either alone or combined with the hCG 2,000 IU, was injected as a trigger. The remainder of the females underwent short-acting long luteal phase stimulation protocols (Jin et al, 2019). Oocytes were observed closely via transvaginal ultrasound.…”