Comparative study on the production of poly(3-hydroxybutyrate) by thermophilic Chelatococcus daeguensis TAD1: a good candidate for large-scale production

Xu, Fuqian; Huang, Shaobin; Liu, Yong; Zhang, Yongqing; Chen, Shaowei

doi:10.1007/s00253-014-5524-y

Cited by 43 publications

(19 citation statements)

References 48 publications

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“…Although few thermophilic bacteria have shown PHB accumulating capacity, operating at thermophilic conditions is not a novel idea for PHB production. Additional advantages have been realised, such as increased diffusion rates, higher solubility of non-gaseous substrates and reduced risk of contamination (47). Production of PHB from thermophilic methanotrophs has not yet been reported.…”

Section: Benefits Of Thermophilic Fermentationmentioning

confidence: 99%

Techno-economic assessment of poly-3-hydroxybutyrate (PHB) production from methane—The case for thermophilic bioprocessing

Levett

Birkett

Davies

et al. 2016

Journal of Environmental Chemical Engineering

128

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, Techno-economic assessment of poly-3-hydroxybutyrate (PHB) production from methane-The case for thermophilic bioprocessing, Journal of Environmental Chemical Engineering http://dx.doi.org/10.1016/j.jece. 2016.07.033 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractA major obstacle preventing the large scale production of polyhydroxyalkanoates (PHAs) has been the lack of a reliable, low cost, large volume feedstock. The abundance and relatively low price of methane therefore marks it as a substrate of interest. This paper presents a technoeconomic assessment of the production of poly-3-hydroxybutyrate (PHB) from methane.ASPEN Plus was used for process design and simulation. The design and economic evaluation is presented for production of 100,000 t/a PHB through methanotrophic fermentation and acetone-water solvent extraction. Production costs were estimated at $4.1-$6.8/kg PHA, which compares against a median price of $7.5/kg from other studies. Raw material costs are reduced from 30-50% of production for sugar feedstocks, to 22% of production for methane. A feature of the work is the revelation that heat removal from the two-stage bioreactor process contributes 28% of the operating cost. Thermophilic methanotrophs could allow the use of cooling water instead of refrigerant, reducing production costs to $3.2-5.4/kg PHA; it is noted that PHB producing thermophilic methanotrophs are yet to be isolated. Energy consumption for air compression and biomass drying were also identified as significant capital and operating costs and therefore optimisation of bioreactor height and pressure and biomass moisture content should be considered in future research.3

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Section: Benefits Of Thermophilic Fermentationmentioning

confidence: 99%

Techno-economic assessment of poly-3-hydroxybutyrate (PHB) production from methane—The case for thermophilic bioprocessing

Levett

Birkett

Davies

et al. 2016

Journal of Environmental Chemical Engineering

128

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“…39 Such findings are important for economic bioprocessing due to the operational advantages offered by the thermophiles, as mentioned above in the introduction. The capability of these thermophiles to utilize wastes as substrates is another added advantage.…”

Section: Batch Fermentationmentioning

confidence: 99%

Strategies for Large-scale Production of Polyhydroxyalkanoates

Kaur

Roy

2015

Chem.Biochem.Eng.Q.

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Polyhydroxyalkanoates (PHAs) are biodegradable and biocompatible intracellular polyesters that are accumulated as energy and carbon reserves by bacterial species, under nutrient limiting conditions. Successful large-scale production of PHAs is dependent on three crucial factors, which include the cost of substrate, downstream processing cost, and process development. In this respect, design and implementation of bioprocess strategies for efficient PHA bioconversions enable high PHA concentrations, yields and productivities. Additionally, development of PHA fermentation processes using inexpensive substrates, such as agro-industrial wastes, facilitates further cost reduction, thus benefitting large-scale PHA production. Thus, the aim of this review is to highlight various bioprocess strategies for high production of PHAs and their novel copolymers in relatively large quantities. This review also discusses the application of kinetic analysis and mathematical modelling as important tools for process optimization and thus improvement of the overall process economics for large-scale production of PHAs.

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“…strain MW10, was isolated by Xu et al [108] from a biological mat of a biotrickling filter designated for NO x removal, and extensively investigated and compared to other PHB-producing microbes. This organism is a thermophilic PHB-producing bacterium.…”

Section: Thermophile Pha Producersmentioning

confidence: 99%

Production of Polyhydroxyalkanoate (PHA) Biopolyesters by Extremophiles?

Koller¹

2017

MOJPS

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The article reviews the current state of knowledge of the production of polyhydroxyalkanoate (PHA) biopolyesters under extreme environmental conditions.Although PHA production by extremophiles is not realized yet at industrial scale, significant PHA accumulation under high salinity or extreme pH-or temperature conditions was reported for diverse representatives of the microbial domains of both Archaea and Bacteria. Several mechanisms were proposed to explain the mechanistic role of PHA and their monomers as microbial cell-and enzyme protective chaperons and the factors boosting PHA biosynthesis under environmental stress conditions. The potential of selected extremophile strains, isolated from extreme environments like glaciers, hot springs, saline brines, or from habitats highly polluted with heavy metals or solvents, for efficient future PHA production on an industrially relevant scale is assessed based on the basic data available in the scientific literature. The article reveals that, beside the needed optimization of other cost-decisive factors like inexpensive raw materials or efficient downstream processing, the application of extremophile production strains can drastically safe energy costs, are easily accessible towards long-term cultivation in chemostat processes, and therefore might pave the way towards cost-efficient PHA production, even combined with safe disposal of industrial waste streams. However, further challenges have still to be overcome in terms of strain improvement and process engineering aspects.

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Comparative study on the production of poly(3-hydroxybutyrate) by thermophilic Chelatococcus daeguensis TAD1: a good candidate for large-scale production

Cited by 43 publications

References 48 publications

Techno-economic assessment of poly-3-hydroxybutyrate (PHB) production from methane—The case for thermophilic bioprocessing

Techno-economic assessment of poly-3-hydroxybutyrate (PHB) production from methane—The case for thermophilic bioprocessing

Strategies for Large-scale Production of Polyhydroxyalkanoates

Production of Polyhydroxyalkanoate (PHA) Biopolyesters by Extremophiles?

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