Comparative toxicity of gentamicin versus tobramycin: a randomized prospective study

Increased renal DNA synthesis in vivo after administration of low doses of gentamicin to rats

“…Healthy volunteers (<40 years of age) have shown no significant alteration of kidney function upon a 10-day exposure to gentamicin (29). Conversely, elevation of serum creatinine was seen in 10 to 37% of ill patients (average age, >60 years) treated for the same time period or less (7,26,30). Other situations in which kidney regeneration rates might differ from normal would be worthy of investigation.…”

“…Synthesis was measured by incorporation of [3H]thymidine into DNA 1 h after intraperitoneal injection of the labeled precursor (200 ,uCi per animal). Gentamicin given in one injection per day resulted in a greater incorporation of [3H]thymidine into DNA after both 7 and 14 days of treatment as compared with control animals. When the daily dose was divided into three equal injections given at 8-h intervals, a statistically significant increase in thymidine incorporation was observed as early as 4 days after starting gentamicin administration.…”

Aminoglycoside-induced hearing loss in humans

“…Most studies consider ototoxicity to have occurred if at any time after a base-line audiogram has been obtained an increase occurs in the auditory threshold of 15 dB or more at any two frequencies (38,45,52,53,55,58,61,72) or 20 dB at one or more frequencies (5, 21,25,27). Some investigators consider a 15-dB or greater change at any frequency to represent ototoxicity (4, 29,40,50,76,[80][81][82][83]94), and others use some combination of criteria (10,32,33,66). The basis for accepting a 15-dB change in threshold as a meaningful change is that it is standard procedure to use 5-dB steps in sound intensity when obtaining auditory thresholds.…”

Gentamicin Reduces Serum ACE Activity in Patients with Normal Kidney Function

“…Regarding nephrotoxicity, the results of studies in humans have so far been inconclusive [14,15]. One reason for these contradictory reports is the limited sensitivity of the most commonly used indicator of aminoglycoside nephrotoxicity, that is, the increase in serum creatinine.…”