Comparative Transcriptome Analysis of the Expression of Antioxidant and Immunity Genes in the Spleen of a Cyanidin 3-O-Glucoside-Treated Alzheimer’s Mouse Model

Jaiswal, Varun; Park, Miey; Lee, Hae‐Jeung

doi:10.3390/antiox10091435

Cited by 20 publications

(13 citation statements)

References 79 publications

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“…The addition of BANCs to the DSS-induced flies increased the NRF2, GSTS, and SOD expression levels compared with those in the inflamed group. The above-described results confirmed the effect of BANCs in modulating the antioxidant cell pathway, which was consistent with the results reported by Jaiswal et al [ 35 ]. The expression of genes in the NRF2 signaling pathways had a significant direct consequence on the marker levels of redox production, such as ROS and MDA ( Figure 5 and Figure 7 b).…”

Section: Discussionsupporting

confidence: 92%

Protective Effect of Bilberry Anthocyanin Extracts on Dextran Sulfate Sodium-Induced Intestinal Damage in Drosophila melanogaster

Zhang

Dai

2022

Nutrients

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Inflammatory bowel disease (IBD) is a chronic recurrent disease that can be controlled by various natural extracts. Anthocyanins (ANCs) from bilberry have significant antioxidant capacity and are widely used as food colors and antioxidants. In this study, we investigated the protective effects of bilberry anthocyanin extracts (BANCs) against dextran sulphate sodium (DSS)-induced intestinal inflammation in a Drosophila melanogaster (D. melanogaster) model, and the effects on the lifespan, antioxidant capacity, intestinal characteristics, and microbiome and gene expression profiles were analyzed to elucidate the underlying biological mechanisms. In DSS-induced normal and axenic D. melanogaster, BANCs significantly increased the survival rate, maintained the intestinal morphology and integrity, and reduced the number of dead intestinal epithelial cells and the ROS level of these cells. BANC supplementation had no significant effect on the intestinal microflora of DSS-induced D. melanogaster, as demonstrated by a 16S rDNA analysis, but improved the antioxidant capacity by activating the relative gene expression of NRF2 signaling pathways in the intestine of D. melanogaster with DSS-induced inflammation. Therefore, the results demonstrate that BANCs effectively alleviate intestinal inflammatory injury induced by DSS and improve the antioxidant capacity of D. melanogaster by modulating NRF2 signaling pathways, and could thus promote the application of BANCs as functional foods.

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Section: Discussionsupporting

confidence: 92%

Protective Effect of Bilberry Anthocyanin Extracts on Dextran Sulfate Sodium-Induced Intestinal Damage in Drosophila melanogaster

Zhang

Dai

2022

Nutrients

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“…Whole transcriptome analysis has been used to study gene expression-based mechanisms of treatment in different organisms [ 6 , 36 , 37 , 38 , 39 ]. In this study, RNA-Seq analysis was applied to study the entire transcriptome expression in the different groups of dogs to understand the biological mechanism important for the anti-inflammatory and anti-obesity effects of the diet.…”

Section: Discussionmentioning

confidence: 99%

Mulberry Leaf Supplements Effecting Anti-Inflammatory Genes and Improving Obesity in Elderly Overweight Dogs

Park

Jaiswal²,

Kim³

et al. 2022

IJMS

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Overweight and obesity, associated with various health complications, refer to abnormal or excessive fat accumulation conditions that harm health. Like humans, obesity is a growing problem in dogs, which may increase the risk of serious diseases such as diabetes and cancer. Mulberry leaf has shown potential anti-obesity and anti-diabetes effects in several studies. Our research studied the impact of mulberry leaf supplements in healthy old overweight dogs for 12 weeks. Blood and fecal samples were collected from the dogs before and after treatment for different analyses, including whole transcriptome and gut microbiome analysis. The Body Condition Score (BCS) and blood glucose levels were significantly decreased in all mulberry treatment groups, which justifies the anti-obesity effect of mulberry leaf in dogs. Throughout the whole transcriptome study, the downregulation of PTX3 and upregulation of PDCD-1, TNFRSF1B, RUNX3, and TICAM1 genes in the high mulberry group were found, which have been associated with anti-inflammatory effects in the literature. It may be an essential gene expression mechanism responsible for the anti-inflammatory and, subsequently, anti-obesity effects associated with mulberry leaf treatment, as confirmed by real-time polymerase chain reaction analysis. In microbiome analysis, Papillibacter cinnamivorans, related to the Mediterranean diet, which may cause anti-inflammatory effects, were abundant in the same treatment group. Further studies may be required to establish the gene expression mechanism and role of abundant bacteria in the anti-obesity effect of mulberry supplements in dogs. Overall, we propose mulberry leaves as a portion of food supplements for improving blood glucose levels and the anti-inflammation of blood in companion dogs.

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“…Among the neurodegenerative disorders, AD is the most common, becoming the sixth leading cause of death in the United States [40]. Medicinal plants and their important constituents can be considered as potential treatments for neurodegenerative disorders according to earlier literature [41,42].…”

Section: Neurodegenerative Disorder: Acetylcholinesterase Inhibition ...mentioning

confidence: 99%

Biological Activities and Phytochemicals of Lungworts (Genus Pulmonaria) Focusing on Pulmonaria officinalis

et al. 2022

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Lungworts (members of genus Pulmonaria), especially Pulmonaria officinalis, have been used as medicinal plants in folk and traditional medicine. The potential biological activities of lungworts, such as antioxidant, anti-inflammatory, anti-neurodegenerative, skin whitening, anticoagulant, antibacterial, anti-anemic, anticonvulsant, and wound-healing properties, have been observed in different studies. More than 90 phytochemicals belonging to pharmacologically active phytochemical classes have been reported for lungworts, which can be considered as one of the important contributors to the biological properties along with micronutrients. However, safety studies and clinical trials are missing for lungworts to establish most of their potential biological properties. Similarly, in vivo studies are lacking for anti-inflammatory and anti-neurodegenerative disorders and more in vivo studies are required to strengthen the knowledge of their antioxidant, anticoagulant, and anti-convulsant properties. A comprehensive compilation of the phytochemicals and biological properties of lungworts is also lacking in the literature, which can provide future direction for further pharmacological research. Hence, an attempt has been made in this study to compile the phytochemicals and biological properties to not only provide the resources for the design of further research to develop the pharmacological application of lungworts, but also to highlight the gaps and provide suggestions for future development.

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Comparative Transcriptome Analysis of the Expression of Antioxidant and Immunity Genes in the Spleen of a Cyanidin 3-O-Glucoside-Treated Alzheimer’s Mouse Model

Cited by 20 publications

References 79 publications

Protective Effect of Bilberry Anthocyanin Extracts on Dextran Sulfate Sodium-Induced Intestinal Damage in Drosophila melanogaster

Protective Effect of Bilberry Anthocyanin Extracts on Dextran Sulfate Sodium-Induced Intestinal Damage in Drosophila melanogaster

Mulberry Leaf Supplements Effecting Anti-Inflammatory Genes and Improving Obesity in Elderly Overweight Dogs

Biological Activities and Phytochemicals of Lungworts (Genus Pulmonaria) Focusing on Pulmonaria officinalis

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