2020
DOI: 10.21203/rs.3.rs-55997/v2
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Comparative transcriptomic analysis of antimony resistant and susceptible Leishmania infantum lines

Abstract: Background: One of the major challenges for leishmaniasis treatment is the emergence of parasites resistant to antimony. In order to study differentially expressed genes associated with drug resistance we performed a comparative transcriptomic analysis between wild-type and potassium antimonyl tartrate (SbIII)-resistant Leishmania infantum lines using high-throughput RNA sequencing.Methods: All the cDNA libraries were constructed from promastigote forms of each line, sequenced and analyzed using STAR for mappi… Show more

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