Comparative Ultrastructural Study of the Ito Cells in the Liver in Some Reptiles

Taira, Katsuya; Mutoh, H.

doi:10.1679/aohc1950.44.373

Cited by 13 publications

(16 citation statements)

References 21 publications

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“…NoPANITAYA et al (1979a, b) revealed collagen fibrils in the Disse's space only around large sinusoids in five piscine species including goldfish. In lower vertebrates such as reptiles, amphibia and lamprey, collagen fibrils were demonstrated in the Disse's sapce by SPORNITZ (1975), SHIN (1977), PEEK et al (1979) and TAIRA and MUTOH (1981. TANUMA and ITO (1980), however have revealed in crucian livers the presence of fine filaments probably belonging to type IV collagen (MILLER and MATUKAS, 1974;POPPER, 1977) and proved that they increased in amount after administration of large doses of vitamin A.…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that both in the larval and adult lamprey the hepatocytes do not protrude microvilli into the Disse's sapce, but, instead, the perisinusoidal surfaces of the hepatocytes are deeply infolded covered by a basal lamina (SHIN, 1977;PEEK et al, 1979). By contrast, perisinusoidal microvilli of the hepatocyte are well developed in fishes, amphibia and reptiles (SPORNITZ, 1975;TANUMa and ITO, 1980;FUJITA et al, 1980;SHIN, 1981;TAIRA and MUTOH, 1981), while the perisinusoidal surface of hepatocytes of these lower vertebrates is lacking in the basal lamina. Thus, it has been suspected that subsequent to the appearance of microvilli, the basal lamina covering the perisinusoidal surface of the hepatocytes might disappear.…”

Section: Discussionmentioning

confidence: 99%

“…The images of the discontinuous endothelium with diaphragma-lacking f enestrae often gathered into clusters, "sieve plates", agreed with the findings in the goldfish (NOPANITAYA et al, 1979a) and in the crucian liver (TANUMA and ITO,1980). The discontinuous endothelium of the hepatic sinusoid is a common feature in lower vertebrates, i.e., reptiles, amphibia, fishes and cyclostomata (SPORNITZ,1975;SHIN, 1977;PEEK et al, 1979;TANUMA and ITO, 1980;FUJITA et al, 1980;TAIRA and MUTOH, 1981). Only in the lamprey has it been proposed that the basal lamina occurs not only at the base of the hepatocytes PEEK et al,1979) but also along the sinusoidal endothelium (SHIN, 1977) and that several fenestrae of the membraneous extension of the sinusoidal endothelium sometimes contain diaphragma (PEEK et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

“…Not very common were the so-called "empty Ito cells", whose existence has recently been recognized by FUJITA et al (1980) andSHIN (1981) in goldfish livers and by TAIRA and MUTOH (1981) in reptile livers. The ultrastructural characteristics of the Ito cells were readily confirmed in the empty Ito cells.…”

Section: Discussionmentioning

confidence: 99%

“…Although Kupffer cells have been revealed in the hepatic sinusoids of lower vertebrates such as lamprey (SHIN, 1977;PEEK et al, 1979), amphibia (SPORNITZ, 1975 and reptiles (lizard, snake and turtle) (TAIRA and MUTOH, 1981), they have scarcely been revealed in piscine livers, or detected only in limited species (SCHMIDT, 1956(SCHMIDT, ,1959ITO, WATANABE and TAKAHASHI, 1962;TANUMA and ITO, 1980;SHIN, 1981;SAKANO and FUJITA, 1981). AWAYA (1977) was able to reveal a few Kupffers in the ray, while he missed them in the crucian carp.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Electron microscopic study on the sinusoidal wall of the liver in the flatfish, Kareius bicoloratus: Demonstration of numerous desmosomes along the sinusoidal wall.

Tanuma

Ohata

Ito

1982

Arch. Histol. Jap., Arch. Histol. Jpn

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Electron microscopic study on the sinusoidal wall of the liver in the flatfish, Kareius bicoloratus: Demonstration of numerous desmosomes along the sinusoidal wall.

Tanuma

Ohata

Ito

1982

Arch. Histol. Jap., Arch. Histol. Jpn

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Resident sinusoidal macrophages in the liver of the brown bullhead (Ictalurus nebulosus): An ultrastructural, functional and cytochemical study

1987

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Ultrastructural, functional, and cytochemical characteristics of resident sinusoidal macrophages (RSM) in brown bullhead (Ictalurus nebulosus) liver were examined. Following perfusion fixation of the hepatic vascular bed, light micrographs revealed RSM that possessed multiple elongate cytoplasmic processes and frequently contained erythrocytes in various stages of degradation. Following brief perfusion fixation, light microscope examination of vibratome sections of bullhead liver reacted for peroxidase revealed intensely positive RSM. By transmission electron microscopy, peroxidase activity was localized to the nuclear envelope and cytoplasmic granules of RSM and in endothelial and perisinusoidal fat-storing cells. In cryostat sections of fresh-frozen liver, glucose-6-phosphate dehydrogenase (G-6-PDH) was uniformly distributed over hepatocytes, whereas intensely positive punctate staining for G-6-PDH was localized over RSM. To test for phagocytosis by RSM, latex beads (0.81 micron) were injected into a tributary of the hepatic portal vein 2 min prior to perfusion fixation. Latex beads appeared either singly or in dense aggregates within RSM. Ultrastructurally, RSM were characterized by an irregularly shaped, eccentrically located nucleus, electron-dense vacuoles, small patches of granular endoplasmic reticulum, a well-developed Golgi apparatus, elongated mitochondria, desmosomes or desmosome-like densities that served as a source of attachment to endothelial cells, and a centriole with radiating microtubules. Invaginations of the plasma membrane (vermiform processes) characteristic of mammalian Kupffer cells were not observed in bullhead RSM. The results indicated a resident cell population of sinusoidal macrophages in the bullhead liver with properties that partially resembled mammalian Kupffer cells. These results are important for the identification of the normal resident cells in the bullhead liver.

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Kupffer cell structure in the juvenile Nile crocodile,Crocodylus niloticus

Wilpe

Groenewald

2013

Journal of Morphology

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The morphology of Kupffer cells was examined in the liver of the juvenile Nile crocodile using light microscopy and transmission electron microscopy. Pleomorphic Kupffer cells were located in the sinusoids, in the space of Disse, in the hepatic parenchyma and often connected adjacent sinusoids. The cell surfaces were irregular due to the presence of filopodia and lamelliapodia with phagocytosis of white blood cells, red blood cells and thrombocytes being evident. The cells were in close contact with endothelial cells and pit cells in the sinusoidal lumen and with stellate cells in the space of Disse. The cytoplasm contained large phagosomes comprising a combination of ceroid pigment, melanosomes and siderosomes. The nuclei were often indented and eccentrically placed due to the presence of the phagosomes. Conspicuous clusters of membrane-bound tubular organelles with a filamentous or crystalline interior were observed in the cytoplasm. The clusters were sometimes separated into smaller groups around phagosomes. A clear zone existed between the limiting membrane and the interior of these tubular organelles with the electron-dense interior profiles being, respectively, circular, angular or divided. The tubular organelles have not previously been described in Kupffer cells and possibly represent lysosomes with specialized functions. Mitochondria, microtubules, Golgi profiles, granular and smooth endoplasmic reticulum, and a few cytoplasmic lipid droplets were also present. The presence of the tubular organelles and the occurrence of the Kupffer cells in different locations in the liver of the juvenile Nile crocodile are indicative of particularly active and mobile cells.

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Comparative Ultrastructural Study of the Ito Cells in the Liver in Some Reptiles

Cited by 13 publications

References 21 publications

Electron microscopic study on the sinusoidal wall of the liver in the flatfish, Kareius bicoloratus: Demonstration of numerous desmosomes along the sinusoidal wall.

Electron microscopic study on the sinusoidal wall of the liver in the flatfish, Kareius bicoloratus: Demonstration of numerous desmosomes along the sinusoidal wall.

Resident sinusoidal macrophages in the liver of the brown bullhead (Ictalurus nebulosus): An ultrastructural, functional and cytochemical study

Kupffer cell structure in the juvenile Nile crocodile,Crocodylus niloticus

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