Comparative Uptake of BR82 by the Hypophysis and Other Tissues.

Mack, J. F.; Shipley, Reginald A.

doi:10.3181/00379727-80-19506

Cited by 2 publications

(1 citation statement)

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“…This indicates that the highest accumulation of Br should have occurred within the thyroid gland, but in this trial the highest accumulation occurred within the kidney. On the other hand, Abelin and Poretti (1952), Bosshardt et al (1956), Huff et al (1956), Mack and Shipley (1952) and Winnek and Smith (1937) could demonstrate no preferential uptake by the thyroid gland. Cole and Patrick (1958) measured the kidney and intestines as the most active organs to have taken up 82 Br after a 2 hour intraperitoneal administration.…”

Section: Discussionmentioning

confidence: 99%

Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens

Toit

Casey

2012

Livestock Science

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The study pursued the hypothesis that bromine (Br) in drinking water at levels > 0.01 mg Br/L may have detrimental effects on the liver, kidneys and thyroid and the thyroid hormones T 3 and T 4 and that iodine (I) may alleviate the potential hazardous effect of Br. The research was done with mixed Ross broiler chickens over a 42-day post-hatch growth period. The trial design was six treatments, T1: 0 mg Br/L and 0 mg I/L; T2: 1 mg Br/L and 0 mg I/L; T3: 3 mg Br/L and 0 mg I/L; T4: 0 mg Br/L and 0.7 mg I/L; T5: 1 mg Br/L and 0.7 mg I/L; and T6: 3 mg Br/L and 0.7 mg I/L delivered via drinking water and three replicates per treatment with 30 birds per replicate. The effect of Br on T 3 and T 4 levels overall was nonsignificant, but T 3 and T 4 levels decreased between Weeks 4 and 6 with a significant effect at Week 6 on T 3 . Br had an overall effect on the thyroid gland (P = 0.0457), liver (P = 0.0025) and kidney (P = 0.0032), and had accumulated in these three organs. Histopathological assessment showed explicit damage to the livers that received the Br treatments. Iodine (0.07 mg/L) ameliorated the negative effects of high Br (3 mg/L Br) concentration and ingestion.

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Section: Discussionmentioning

confidence: 99%

Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens

Toit

Casey

2012

Livestock Science

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The Toxicology of Bromide Ion

Leeuwen

Sangster

Hildebrandt³

1987

CRC Critical Reviews in Toxicology

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Inorganic bromide is widely distributed in nature. Its natural physiological role in animal life is unknown. More than a century ago bromide was introduced in medicine as an antiepileptic drug. Nowadays, man is primarily exposed to bromide via food as the result of use of bromide-containing fumigants in intensive horticulture and in the treatment of food stocks. In this review exposure of man to bromide is described, and the pharmacological and toxicological effects of bromide ion are discussed.

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Comparative Uptake of BR82 by the Hypophysis and Other Tissues.

Cited by 2 publications

References 2 publications

Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens

Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens

The Toxicology of Bromide Ion

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