Comparing 2.5%, 5%, and 10% Benzoyl Peroxide on Inflammatory Acne Vulgaris

Mills, Otto H.; Kligman, Albert M.; Pochi, Peter E.; Comite, Harriet

doi:10.1111/j.1365-4362.1986.tb04534.x

Cited by 118 publications

(65 citation statements)

References 6 publications

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“…Similar age distribution and female preponderance was seen in a study done by Rallis E et al 10 Group I treated with 5% Benzoyl peroxide were followed up at 2 weeks and 4 weeks which showed 32.3% and 58.03% percentage reduction of number of lesions respectively. This data correlates with the study conducted by Mills OH et al, in 1986, who demonstrated 40.3% and 55.9% percentage of reduction in acne lesions from baseline at the end of 4 weeks and 8 weeks respectively which is in concordance with our study.…”

Section: Discussionsupporting

confidence: 93%

A prospective randomised open labelled comparative study of anti inflammatory effects of topical 5% benzoyl peroxide gel vs topical 4% nicotinamide gel for grade I-II acne in a tertiary care hospital

Kumar¹,

Mohan²,

Shwetha³

et al. 2018

Int J Basic Clin Pharmacol

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Background: Acne vulgaris is a dermatological disorder characterised by formation of comedones and inflammatory lesions. The treatment of acne basically involves reduction of lesions. Benzoyl peroxide, in concentrations of 5%, 10%, and 20%, has been used effectively in the treatment of acne for more than 20 years. Nicotinamide/ Niacinamide is a newly-approved anti-acne drug with a potent anti-inflammatory effect. The present study assessed the efficacy of 5% Benzoyl peroxide gel in comparison to 4% Nicotinamide gel for topical treatment of mild to moderate acne vulgaris.Methods: In this study, the patients with mild to moderate acne vulgaris with inflammation were divided into two groups, group I was treated with topical 5% Benzoyl peroxide gel whereas topical Nicotinamide gel was given to the group II. Assessment of efficacy was done by total lesion counting according acne global severity index, the results were compared at the end of 2 weeks and 4 weeks with the baseline values.Results: At the end of this study, it was found that the reduction of inflammatory and total percentage of decrease in counts of lesions from baseline were highly significant in both the groups (p<0.001), between the groups, differences were statistically significant (p<0.001), therefore 5% Benzoyl peroxide gel has better efficacy than 4% Nicotinamide gel.Conclusions: Benzoyl peroxide is more efficacious than 4 % Nicotinamide gel in mild to moderate acne.

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Section: Discussionsupporting

confidence: 93%

A prospective randomised open labelled comparative study of anti inflammatory effects of topical 5% benzoyl peroxide gel vs topical 4% nicotinamide gel for grade I-II acne in a tertiary care hospital

Kumar¹,

Mohan²,

Shwetha³

et al. 2018

Int J Basic Clin Pharmacol

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show abstract

“…In two trials of 153 patients with mild to moderate acne, Milis et al (57) compared the efficacy of topical benzoyl peroxide at different concentrations (2.5% vs. 5% and 2.5% vs. 10% used twice daily). Based on lesion counts, there were no differences in efficacy among the different concentrations.…”

Section: Tazarotenementioning

confidence: 99%

Isotretinoin and the Risk of Depression in Patients With Acne Vulgaris

Azoulay¹,

Blais²,

Koren³

et al. 2008

J. Clin. Psychiatry

129

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“…In a comparison of 2.5, 5 and 10% gel formulations of benzoyl peroxide, the 2.5% formulation was equivalent to the other two concentrations in reducing inflammatory lesions and significantly reduced P. acnes after 2 weeks of topical application. The local adverse effects were less frequent with the 2.5% gel than with the 10% preparation, but similar to the 5% gel [57]. …”

Section: Benzoylperoxidementioning

confidence: 99%

Topical Treatment in Acne: Current Status and Future Aspects

Gollnick

Krautheim²

2003

Dermatology

111

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During the last 20 years, the number of topical and systemic drugs for the treatment of acne vulgaris has been enriched. Topical drugs on the one hand have been newly discovered or further developments of already available agents such as in the group of retinoids or galenic formulation have improved efficacy or local tolerance. Topical retinoids are a mainstay in acne treatment since 1962. All-trans retinoic acid was the first and is still in use. Its irritative potential has led to the new galenics, i.e. incorporation in microsponges and in propolyomers, which increased the tolerability significantly. The isomer of tretinoin, isotretinoin, has the same clinical efficacy, but also a lower irritancy. A real breakthrough was adapalene, a retinoid-like agent, with a different retinoid receptor-binding profile, but in addition to the same clinical efficacy on inflammatory and non-inflammatory acne lesions compared to tretinoin, a better tolerability and, therefore, compliance. Unfortunately, over the past years topical retinoids have been less used in inflammatory acne than they should be, taking the the mechanisms of action into account. Topical antimicrobials, in particular topical antibiotics, should be used less often than in the past and only for short periods to avoid the development of resistances. It seems better to combine those agents with topical retinoids, with BPO or with azelaic acid to enhance the efficacy and slow down the development of resistance. BPO is still the gold standard for papular-pustular acne of mild-to-moderate type in concentrations of 2–5%. Azelaic acid is an alternative with efficacy on the comedo and is antibacterial without development of resistances. Finally, the physical removal by electrocautery or CO₂ laser of multiple densely packed closed comedones, macrocomedones and microcysts is necessary to enhance the efficacy of topical comedolytic agents and to speed up the therapeutic results. Photodynamic therapy has not yet been proven efficacious in controlled studies. Blue and red light can probably be used in association with local agents but enhancement of the irritative potential of topical and systemic agents has to be considered.

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Comparing 2.5%, 5%, and 10% Benzoyl Peroxide on Inflammatory Acne Vulgaris

Cited by 118 publications

References 6 publications

A prospective randomised open labelled comparative study of anti inflammatory effects of topical 5% benzoyl peroxide gel vs topical 4% nicotinamide gel for grade I-II acne in a tertiary care hospital

A prospective randomised open labelled comparative study of anti inflammatory effects of topical 5% benzoyl peroxide gel vs topical 4% nicotinamide gel for grade I-II acne in a tertiary care hospital

Isotretinoin and the Risk of Depression in Patients With Acne Vulgaris

Topical Treatment in Acne: Current Status and Future Aspects

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